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Ethosuximide
Zarontin (ethosuximide) is a small molecule pharmaceutical. Ethosuximide was first approved as Zarontin on 1982-01-01. It is used to treat absence epilepsy and epilepsy in the USA.
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
nervous system diseasesD009422
Trade Name
FDA
EMA
Zarontin (generic drugs available since 1982-01-01)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Ethosuximide
Tradename
Company
Number
Date
Products
ZARONTINPfizerN-012380 RX1982-01-01
1 products, RLD, RS
Labels
FDA
EMA
Brand Name
Status
Last Update
zarontinANDA2023-06-09
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
absence epilepsyHP_0011147D004832G40.A
epilepsyEFO_0000474D004827G40.9
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
N: Nervous system drugs
N03: Antiepileptics
N03A: Antiepileptics
N03AD: Succinimide derivatives, antiepileptics
N03AD01: Ethosuximide
N03AD51: Ethosuximide, combinations
HCPCS
No data
Clinical
Clinical Trials
4 clinical trials
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Indications Phases 4
No data
Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
TuberculosisD014376EFO_0000774A15-A191112
Multidrug-resistant tuberculosisD018088EFO_0007381111
Extensively drug-resistant tuberculosisD054908111
Indications Phases 2
No data
Indications Phases 1
No data
Indications Without Phase
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Hiv infectionsD015658EFO_0000764B2022
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameETHOSUXIMIDE
INNethosuximide
Description
Ethosuximide is a dicarboximide that is pyrrolidine-2,5-dione in which the hydrogens at position 3 are substituted by one methyl and one ethyl group. An antiepileptic, it is used in the treatment of absence seizures and may be used for myoclonic seizures, but is ineffective against tonic-clonic seizures. It has a role as an anticonvulsant, a geroprotector and a T-type calcium channel blocker. It is a pyrrolidinone and a dicarboximide.
Classification
Small molecule
Drug class
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
CCC1(C)CC(=O)NC1=O
Identifiers
PDB
CAS-ID77-67-8
RxCUI4135
ChEMBL IDCHEMBL696
ChEBI ID4887
PubChem CID3291
DrugBankDB00593
UNII ID5SEH9X1D1D (ChemIDplus, GSRS)
Target
Agency Approved
No data
Alternate
No data
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 2,739 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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610 adverse events reported
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