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Ethambutol
Myambutol (ethambutol) is a small molecule pharmaceutical. Ethambutol was first approved as Myambutol on 1982-01-01. It is used to treat mycobacterium infections, nontuberculous mycobacterium infections, and tuberculosis in the USA.
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
infectionsD007239
Trade Name
FDA
EMA
Myambutol (generic drugs available since 1999-11-30)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Ethambutol hydrochloride
Tradename
Company
Number
Date
Products
MYAMBUTOLSTI PharmaN-016320 RX1982-01-01
2 products, RLD, RS
Show 1 discontinued
Labels
FDA
EMA
Brand Name
Status
Last Update
ethambutol hydrochlorideANDA2023-03-30
myambutolNew Drug Application2022-02-15
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
mycobacterium infectionsD009164A31.9
nontuberculous mycobacterium infectionsEFO_0007461D009165A31.9
tuberculosisEFO_0000774D014376A15-A19
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
J: Antiinfectives for systemic use
J04: Antimycobacterials
J04A: Drugs for treatment of tuberculosis
J04AK: Other drugs for treatment of tuberculosis in atc
J04AK02: Ethambutol
J04AM: Combinations of drugs for treatment of tuberculosis
J04AM03: Ethambutol and isoniazid
J04AM06: Rifampicin, pyrazinamide, ethambutol and isoniazid
J04AM07: Rifampicin, ethambutol and isoniazid
HCPCS
No data
Clinical
Clinical Trials
74 clinical trials
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Indications Phases 4
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
TuberculosisD014376EFO_0000774A15-A192992425
Hiv infectionsD015658EFO_0000764B201773421
Pulmonary tuberculosisD014397EFO_1000049A15961419
Mycobacterium avium-intracellulare infectionD015270EFO_0007386531110
Nontuberculous mycobacterium infectionsD009165EFO_0007461A31.91314
Lung diseasesD008171EFO_0003818J98.41123
Spinal tuberculosisD014399A18.0111
ObesityD009765EFO_0001073E66.911
Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
HivD006678O98.7224
Mycobacterium avium complexD015269122
Acquired immunodeficiency syndromeD000163EFO_0000765B20122
Multidrug-resistant tuberculosisD018088EFO_000738122
Anterior uveitisD014606EFO_100081111
Extensively drug-resistant tuberculosisD05490811
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
SarcoidosisD012507EFO_0000690D80-D8911
Meningeal tuberculosisD014390A17.011
Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Pulmonary sarcoidosisD017565DOID_13406D86.011
Indications Without Phase
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Cystic fibrosisD003550EFO_0000390E8411
Body weight changesD00183611
Motor activityD009043EFO_000394011
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameETHAMBUTOL
INNethambutol
Description
Ethambutol is an ethylenediamine derivative that is ethane-1,2-diamine in which one hydrogen attached to each of the nitrogens is sutstituted by a 1-hydroxybutan-2-yl group (S,S-configuration). It is a bacteriostatic antimycobacterial drug, effective against Mycobacterium tuberculosis and some other mycobacteria. It is used (as the dihydrochloride salt) in combination with other antituberculous drugs in the treatment of pulmonary and extrapulmonary tuberculosis; resistant strains of M. tuberculosis are readily produced if ethambutol is used alone. It has a role as an antitubercular agent, an environmental contaminant and a xenobiotic. It is a member of ethanolamines and an ethylenediamine derivative.
Classification
Small molecule
Drug class
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
CC[C@@H](CO)NCCN[C@@H](CC)CO
Identifiers
PDB
CAS-ID74-55-5
RxCUI4110
ChEMBL IDCHEMBL44884
ChEBI ID4877
PubChem CID14052
DrugBankDB00330
UNII ID8G167061QZ (ChemIDplus, GSRS)
Target
Agency Approved
No data
Alternate
No data
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 17,905 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
0 adverse events reported
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