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Esmolol
Brevibloc (esmolol) is a small molecule pharmaceutical. Esmolol was first approved as Brevibloc on 1988-08-15. It is used to treat angina pectoris, heart failure, hypertension, myocardial infarction, and supraventricular tachycardia amongst others in the USA. The pharmaceutical is active against beta-1 adrenergic receptor.
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
cardiovascular diseasesD002318
signs and symptoms pathological conditionsD013568
Trade Name
FDA
EMA
Brevibloc (generic drugs available since 2004-08-10)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Esmolol hydrochloride
Tradename
Company
Number
Date
Products
BREVIBLOCBaxterN-019386 RX2003-02-25
1 products, RLD, RS
BREVIBLOC DOUBLE STRENGTH IN PLASTIC CONTAINERBaxterN-019386 RX2003-01-27
1 products, RLD, RS
BREVIBLOC IN PLASTIC CONTAINERBaxterN-019386 RX2001-02-16
1 products, RLD, RS
ESMOLOL HYDROCHLORIDE IN PLASTIC CONTAINERHQ Specialty PharmaN-205703 RX2016-04-07
1 products, RLD, RS
ESMOLOL HYDROCHLORIDE DOUBLE STRENGTH IN PLASTIC CONTAINERHQ Specialty PharmaN-205703 RX2016-04-07
1 products, RLD, RS
Show 1 discontinued
Labels
FDA
EMA
Brand Name
Status
Last Update
breviblocNew Drug Application2018-04-30
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
angina pectorisEFO_0003913D000787I20
heart failureEFO_0003144D006333I50
hypertensionEFO_0000537D006973I10
myocardial infarctionEFO_0000612D009203I21
supraventricular tachycardiaHP_0004755D013617I47.1
ventricular fibrillationEFO_0004287D014693I49.01
ventricular tachycardia—D017180I47.2
Agency Specific
FDA
EMA
No data
Patent Expiration
Patent
Expires
Flag
FDA Information
Esmolol Hydrochloride, Esmolol Hydrochloride Double Strength In Plastic Container, Hq Spclt Pharma
88290542033-03-15DP
88355052033-03-15DP
ATC Codes
C: Cardiovascular system drugs
— C07: Beta-adrenergic blocking agents
— C07A: Beta blocking agents
— C07AB: Beta blocking agents, selective
— C07AB09: Esmolol
HCPCS
No data
Clinical
Clinical Trials
58 clinical trials
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Indications Phases 4
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
EpilepsyD004827EFO_0000474G40.928272241
Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Partial epilepsiesD004828EFO_0004263214——7
Diabetic neuropathiesD003929EFO_1000783—11——2
Postherpetic neuralgiaD051474—11——2
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Bipolar disorderD001714EFO_0000289F30.9—3———3
Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
NeuralgiaD009437EFO_00094301————1
Indications Without Phase
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
AgingD000375GO_0007568R41.81————11
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameESMOLOL
INNesmolol
Description
Methyl 3-{4-[2-hydroxy-3-(propan-2-ylamino)propoxy]phenyl}propanoate is a methyl ester that is methyl 3-(4-hydroxyphenyl)propanoate in which the hydrogen attached to the phenolic hydroxy group is substituted by a 2-hydroxy-3-(isopropylamino)propyl group. It is an aromatic ether, a member of ethanolamines, a methyl ester, a secondary alcohol and a secondary amino compound. It is functionally related to a 3-{4-[2-hydroxy-3-(propan-2-ylamino)propoxy]phenyl}propanoic acid.
Classification
Small molecule
Drug classbeta-blockers (propranolol type)
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
COC(=O)CCc1ccc(OCC(O)CNC(C)C)cc1
Identifiers
PDB—
CAS-ID81147-92-4
RxCUI49737
ChEMBL IDCHEMBL768
ChEBI ID88206
PubChem CID59768
DrugBankDB00187
UNII IDMDY902UXSR (ChemIDplus, GSRS)
Target
Agency Approved
ADRB1
ADRB1
Organism
Homo sapiens
Gene name
ADRB1
Gene synonyms
ADRB1R, B1AR
NCBI Gene ID
153
Protein name
beta-1 adrenergic receptor
Protein synonyms
adrenergic, beta-1-, receptor, Beta-1 adrenoceptor, Beta-1 adrenoreceptor
Uniprot ID
P08588
Mouse ortholog
Adrb1 (11554)
beta-1 adrenergic receptor (P34971)
Alternate
No data
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 3,435 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
Mock data
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2,145 adverse events reported
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