Esmolol
Brevibloc (esmolol) is a small molecule pharmaceutical. Esmolol was first approved as Brevibloc on 1988-08-15. It is used to treat angina pectoris, heart failure, hypertension, myocardial infarction, and supraventricular tachycardia amongst others in the USA. The pharmaceutical is active against beta-1 adrenergic receptor.
Download report
Favorite
Commercial
Trade Name
FDA
EMA
Brevibloc (generic drugs available since 2004-08-10)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Esmolol hydrochloride
Tradename | Company | Number | Date | Products |
---|---|---|---|---|
BREVIBLOC | Baxter | N-019386 RX | 2003-02-25 | 1 products, RLD, RS |
BREVIBLOC DOUBLE STRENGTH IN PLASTIC CONTAINER | Baxter | N-019386 RX | 2003-01-27 | 1 products, RLD, RS |
BREVIBLOC IN PLASTIC CONTAINER | Baxter | N-019386 RX | 2001-02-16 | 1 products, RLD, RS |
ESMOLOL HYDROCHLORIDE IN PLASTIC CONTAINER | HQ Specialty Pharma | N-205703 RX | 2016-04-07 | 1 products, RLD, RS |
ESMOLOL HYDROCHLORIDE DOUBLE STRENGTH IN PLASTIC CONTAINER | HQ Specialty Pharma | N-205703 RX | 2016-04-07 | 1 products, RLD, RS |
Show 1 discontinued
Labels
FDA
EMA
Brand Name | Status | Last Update |
---|---|---|
brevibloc | New Drug Application | 2018-04-30 |
esmolol hydrochloride | ANDA | 2023-05-30 |
Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
---|---|---|---|
angina pectoris | EFO_0003913 | D000787 | I20 |
heart failure | EFO_0003144 | D006333 | I50 |
hypertension | EFO_0000537 | D006973 | I10 |
myocardial infarction | EFO_0000612 | D009203 | I21 |
supraventricular tachycardia | HP_0004755 | D013617 | I47.1 |
ventricular fibrillation | EFO_0004287 | D014693 | I49.01 |
ventricular tachycardia | — | D017180 | I47.2 |
Agency Specific
FDA
EMA
No data
HCPCS
No data
Clinical
Clinical Trials
58 clinical trials
View more details
![](https://www.pharmakb.com/hubfs/raw_assets/public/ccd-theme/images/generated-html-images/trials-plot.png)
Mock data
Subscribe for the real data
Subscribe for the real data
Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Epilepsy | D004827 | EFO_0000474 | G40.9 | 28 | 2 | 7 | 2 | 2 | 41 |
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Partial epilepsies | D004828 | EFO_0004263 | 2 | 1 | 4 | — | — | 7 | |
Diabetic neuropathies | D003929 | EFO_1000783 | — | 1 | 1 | — | — | 2 | |
Postherpetic neuralgia | D051474 | — | 1 | 1 | — | — | 2 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Bipolar disorder | D001714 | EFO_0000289 | F30.9 | — | 3 | — | — | — | 3 |
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Neuralgia | D009437 | EFO_0009430 | 1 | — | — | — | — | 1 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Aging | D000375 | GO_0007568 | R41.81 | — | — | — | — | 1 | 1 |
Epidemiology
Epidemiological information for investigational and approved indications
View more details
Drug
General
Drug common name | ESMOLOL |
INN | esmolol |
Description | Methyl 3-{4-[2-hydroxy-3-(propan-2-ylamino)propoxy]phenyl}propanoate is a methyl ester that is methyl 3-(4-hydroxyphenyl)propanoate in which the hydrogen attached to the phenolic hydroxy group is substituted by a 2-hydroxy-3-(isopropylamino)propyl group. It is an aromatic ether, a member of ethanolamines, a methyl ester, a secondary alcohol and a secondary amino compound. It is functionally related to a 3-{4-[2-hydroxy-3-(propan-2-ylamino)propoxy]phenyl}propanoic acid. |
Classification | Small molecule |
Drug class | beta-blockers (propranolol type) |
Image (chem structure or protein) | |
Structure (InChI/SMILES or Protein Sequence) | COC(=O)CCc1ccc(OCC(O)CNC(C)C)cc1 |
Identifiers
PDB | — |
CAS-ID | 81147-92-4 |
RxCUI | 49737 |
ChEMBL ID | CHEMBL768 |
ChEBI ID | 88206 |
PubChem CID | 59768 |
DrugBank | DB00187 |
UNII ID | MDY902UXSR (ChemIDplus, GSRS) |
Target
Agency Approved
Alternate
No data
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
![](https://www.pharmakb.com/hubfs/raw_assets/public/ccd-theme/images/generated-html-images/top-terms-plot.png)
Mock data
Subscribe for the real data
Subscribe for the real data
Additional graphs summarizing 3,499 documents
View more details
Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
![](https://www.pharmakb.com/hubfs/raw_assets/public/ccd-theme/images/generated-html-images/top-adverse-reactions-plot.png)
Mock data
Subscribe for the real data
Subscribe for the real data
2,145 adverse events reported
View more details
Premium feature
Learn more about premium features at pharmakb.com
Learn more