Escitalopram
Lexapro (escitalopram) is a small molecule pharmaceutical. Escitalopram was first approved as Lexapro on 2002-08-14. It is used to treat major depressive disorder in the USA. The pharmaceutical is active against sodium-dependent serotonin transporter.
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Therapeutic Areas
Therapeutic Area | MeSH |
|---|---|
| mental disorders | D001523 |
Trade Name
FDA
EMA
Lexapro (generic drugs available since 2012-03-14)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Escitalopram oxalate
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| LEXAPRO | AbbVie | N-021323 RX | 2002-08-14 | 3 products, RLD, RS |
Show 1 discontinued
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| escitalopram oxalate | ANDA | 2023-05-01 |
| lexapro | New Drug Application | 2021-09-20 |
Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| major depressive disorder | EFO_0003761 | D003865 | F22 |
Agency Specific
FDA
EMA
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Patent Expiration
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HCPCS
No data
Clinical
Clinical Trials
512 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Major depressive disorder | D003865 | EFO_0003761 | F22 | 11 | 24 | 29 | 52 | 20 | 129 |
| Depression | D003863 | F33.9 | 5 | 16 | 19 | 50 | 35 | 117 | |
| Healthy volunteers/patients | — | 24 | — | — | 4 | 4 | 32 | ||
| Anxiety disorders | D001008 | EFO_0006788 | F41.1 | 3 | 2 | 6 | 8 | 4 | 22 |
| Depressive disorder | D003866 | EFO_1002014 | F32.A | 4 | 1 | 6 | 2 | 3 | 15 |
| Anxiety | D001007 | EFO_0005230 | F41.1 | — | 1 | 3 | 5 | 6 | 14 |
| Schizophrenia | D012559 | EFO_0000692 | F20 | — | — | 2 | 8 | 1 | 11 |
| Alzheimer disease | D000544 | EFO_0000249 | F03 | 1 | 1 | 3 | 4 | 2 | 10 |
| Bipolar disorder | D001714 | EFO_0000289 | F30.9 | 1 | 2 | 2 | 3 | 2 | 9 |
| Obsessive-compulsive disorder | D009771 | EFO_0004242 | F42 | — | — | 1 | 6 | 1 | 8 |
Show 48 more
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Treatment-resistant depressive disorder | D061218 | 1 | — | 7 | — | 1 | 9 | ||
| Neoplasms | D009369 | C80 | 1 | 1 | 4 | — | 1 | 7 | |
| Cocaine-related disorders | D019970 | F14 | 1 | 5 | 1 | — | — | 6 | |
| Mood disorders | D019964 | EFO_0004247 | F30-F39 | — | 1 | 1 | — | 2 | 4 |
| Parkinson disease | D010300 | EFO_0002508 | G20 | — | 2 | 2 | — | 1 | 4 |
| Hot flashes | D019584 | — | — | 1 | — | 3 | 4 | ||
| Breast neoplasms | D001943 | EFO_0003869 | C50 | — | 1 | 1 | — | 1 | 3 |
| Opioid-related disorders | D009293 | EFO_0005611 | F11 | — | 1 | 1 | — | — | 2 |
| Hiv infections | D015658 | EFO_0000764 | B20 | — | — | 2 | — | — | 2 |
| Fibromyalgia | D005356 | EFO_0005687 | M79.1 | — | 1 | 1 | — | 1 | 2 |
Show 23 more
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Menopause | D008593 | EFO_0003922 | N95 | — | 1 | — | — | 1 | 2 |
| Ischemic stroke | D000083242 | 1 | 2 | — | — | — | 2 | ||
| Male infertility | D007248 | EFO_0004248 | N46 | — | 1 | — | — | — | 1 |
| Chronic hepatitis c | D019698 | EFO_0004220 | B18.2 | — | 1 | — | — | — | 1 |
| Aphasia | D001037 | HP_0002381 | R47.01 | — | 1 | — | — | — | 1 |
| Glioma | D005910 | EFO_0000520 | — | 1 | — | — | — | 1 | |
| Chronic kidney failure | D007676 | EFO_0003884 | N18.6 | — | 1 | — | — | — | 1 |
| Bereavement | D001601 | — | 1 | — | — | — | 1 | ||
| Attention deficit disorder with hyperactivity | D001289 | EFO_0003888 | F90 | — | 1 | — | — | — | 1 |
| Neurodevelopmental disorders | D065886 | F89 | — | 1 | — | — | — | 1 |
Show 6 more
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Spinal cord injuries | D013119 | EFO_1001919 | 2 | — | — | — | 1 | 3 | |
| Substance-related disorders | D019966 | EFO_0003890 | F13 | 1 | — | — | — | 1 | 2 |
| Autism spectrum disorder | D000067877 | F84.0 | 1 | — | — | — | 1 | 2 | |
| Stress urinary incontinence | D014550 | HP_0010992 | 1 | — | — | — | — | 1 | |
| Fecal incontinence | D005242 | R15 | 1 | — | — | — | — | 1 | |
| Hepacivirus | D016174 | 1 | — | — | — | — | 1 | ||
| Premature ejaculation | D061686 | HP_0012876 | F52.4 | 1 | — | — | — | — | 1 |
| Respiratory insufficiency | D012131 | HP_0002093 | J96.9 | 1 | — | — | — | — | 1 |
| Hypercapnia | D006935 | 1 | — | — | — | — | 1 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Cardiovascular diseases | D002318 | EFO_0000319 | I98 | — | — | — | — | 4 | 4 |
| Pharmacokinetics | D010599 | — | — | — | — | 2 | 2 | ||
| Cognition | D003071 | EFO_0003925 | — | — | — | — | 2 | 2 | |
| Perimenopause | D047648 | — | — | — | — | 1 | 1 | ||
| Pregnancy | D011247 | EFO_0002950 | Z33.1 | — | — | — | — | 1 | 1 |
| Wounds and injuries | D014947 | T14.8 | — | — | — | — | 1 | 1 | |
| Chronic disease | D002908 | — | — | — | — | 1 | 1 | ||
| Brain injuries | D001930 | S06.9 | — | — | — | — | 1 | 1 | |
| Alcohol-related disorders | D019973 | F10 | — | — | — | — | 1 | 1 | |
| Suicidal ideation | D059020 | EFO_0004320 | R45.851 | — | — | — | — | 1 | 1 |
Show 19 more
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | ESCITALOPRAM |
| INN | escitalopram |
| Description | Escitalopram is a 1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile that has S-configuration at the chiral centre. It is the active enantiomer of citalopram. It has a role as an antidepressant and an EC 3.4.21.26 (prolyl oligopeptidase) inhibitor. It is a conjugate base of an escitalopram(1+). It is an enantiomer of a (R)-citalopram. |
| Classification | Small molecule |
| Drug class | Selective serotonin reuptake inhibitor (SSRI) |
| Image (chem structure or protein) | |
| Structure (InChI/SMILES or Protein Sequence) | CN(C)CCC[C@@]1(c2ccc(F)cc2)OCc2cc(C#N)ccc21 |
Identifiers
| PDB | 5I71 |
| CAS-ID | 128196-01-0 |
| RxCUI | 321988 |
| ChEMBL ID | CHEMBL1508 |
| ChEBI ID | 36791 |
| PubChem CID | 146570 |
| DrugBank | DB01175 |
| UNII ID | 4O4S742ANY (ChemIDplus, GSRS) |
Target
Agency Approved
SLC6A4
SLC6A4
Organism
Homo sapiens
Gene name
SLC6A4
Gene synonyms
HTT, SERT
NCBI Gene ID
Protein name
sodium-dependent serotonin transporter
Protein synonyms
5-hydroxytryptamine (serotonin) transporter, 5HT transporter, 5HTT, Na+/Cl- dependent serotonin transporter, serotonin transporter 1, solute carrier family 6 (neurotransmitter transporter), member 4, solute carrier family 6 (neurotransmitter transporter, serotonin), member 4, Solute carrier family 6 member 4
Uniprot ID
Mouse ortholog
Slc6a4 (15567)
sodium-dependent serotonin transporter (Q60857)
Alternate
No data
Variants
Clinical Variant
Identifier | Target mutation | Effect | Evaluation | Status |
|---|---|---|---|---|
| VCV000638805 | CYP2C19, Gly91Arg | drug response | 2019-06-17 | P |
| VCV000638804 | CYP2C19, His78Tyr | drug response | 2019-06-17 | P |
| VCV000638803 | CYP2C19, Arg73Cys | drug response | 2019-06-17 | P |
| VCV000638802 | CYP2C19, Arg442Cys | drug response | 2019-06-17 | P |
| VCV000638801 | CYP2C19, Ser51Gly | drug response | 2019-06-17 | P |
| VCV000638800 | CYP2C19, Asp256Asn | drug response | 2019-06-17 | P |
| VCV000638799 | CYP2C19, Ile19Leu | drug response | 2019-06-17 | P |
| VCV000638798 | CYP2C19, Lys399=, Arg335Gln | drug response | 2019-06-17 | P |
| VCV000638797 | CYP2C19, Pro227= | drug response | 2019-06-17 | P |
| VCV000638796 | CYP2C19, Arg410Cys | drug response | 2019-06-17 | P |
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Financial
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Trends
PubMed Central
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Safety
Black-box Warning
Black-box warning for: Escitalopram oxalate, Lexapro
Adverse Events
Top Adverse Reactions
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24,393 adverse events reported
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