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Ergoloid mesylates
Alkergot, Circanol, Deapril-st, Gerimal, Hydergine, Hydrogenated Ergot Alkaloids (ergoloid mesylates) is a small molecule pharmaceutical. Ergoloid mesylates was first approved as Hydergine on 1982-01-01.
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Therapeutic Areas
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Trade Name
FDA
EMA
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Drug Products
FDA
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New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Ergoloid mesylates
Tradename
Company
Number
Date
Products
HYDERGINENovartisN-009087 DISCN1982-01-01
2 products
HYDERGINENovartisN-017993 DISCN1982-01-01
2 products
HYDERGINENovartisN-018418 DISCN1982-01-01
1 products
HYDERGINE LCNovartisN-018706 DISCN1983-01-18
1 products
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Labels
FDA
EMA
Brand Name
Status
Last Update
ergoloid mesylatesANDA2017-11-22
Indications
FDA
EMA
No data
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
C: Cardiovascular system drugs
— C04: Peripheral vasodilators
— C04A: Peripheral vasodilators
— C04AE: Ergot alkaloid peripheral vasodilators
— C04AE01: Ergoloid mesylates
— C04AE51: Ergoloid mesylates, combinations
HCPCS
No data
Clinical
Clinical Trials
1797 clinical trials
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Mock data
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Indications Phases 4
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Vitamin d deficiencyD014808EFO_0003762E5538614674251450
OsteoporosisD010024EFO_0003882M81.0919282129104
Covid-19D000086382U07.1361153458
ObesityD009765EFO_0001073E66.9263123255
Healthy volunteers/patients—152322748
Chronic renal insufficiencyD051436N18256151945
Type 2 diabetes mellitusD003924EFO_0001360E11311791844
Metabolic bone diseasesD001851HP_0000938364101536
AsthmaD001249EFO_0000270J4549841134
Postmenopausal osteoporosisD015663EFO_0003854—4713933
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Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Breast neoplasmsD001943EFO_0003869C5081910—436
Prostatic neoplasmsD011471C613126—323
Hiv infectionsD015658EFO_0000764B20294—215
Inflammatory bowel diseasesD015212EFO_0003767322—915
Colorectal neoplasmsD015179172—613
TuberculosisD014376EFO_0000774A15-A19—32—813
AgingD000375GO_0007568R41.81121—811
PregnancyD011247EFO_0002950Z33.1113—611
NeoplasmsD009369C80315—210
Ulcerative colitisD003093EFO_0000729K51321—510
Show 96 more
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
HyperparathyroidismD006961EFO_0008506E21.311——46
Bone densityD015519EFO_0003923M85—1——45
Stress fracturesD015775M84.3—1——45
AtherosclerosisD050197EFO_0003914I25.1—1——45
Pre-eclampsiaD011225EFO_0000668O1411——45
Rectal neoplasmsD01200411——24
Ovarian neoplasmsD010051EFO_0003893C5612——14
Female infertilityD007247EFO_0008560N97—1——34
ArthralgiaD018771HP_0002829M25.5—2——24
Hematopoietic stem cell transplantationD01838011——34
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Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Nutritional statusD0097521———34
PeriodontitisD010518EFO_0000649K05.31———34
Periodontal diseasesD010510K05.61———34
Thyroid diseasesD013959HP_0000820E00-E071———23
Tibial fracturesD013978EFO_0003944S82.201———12
Morbid obesityD009767EFO_00010741———12
GrowthD0061281———12
Breast densityD0000710601————1
Chronic progressive multiple sclerosisD0205281————1
Pituitary acth hypersecretionD047748EFO_1001110E24.01————1
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Indications Without Phase
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Wounds and injuriesD014947T14.8————33
Drug-related side effects and adverse reactionsD064420T88.7————33
Weight lossD015431HP_0001824————33
Diet therapyD004035————22
HeadacheD006261HP_0002315R51————22
Allergic rhinitisD065631J30.9————22
Vitamin k deficiencyD014813E56.1————22
Fracture healingD017102————22
Female genital diseasesD005831EFO_0009549N85————22
HypercholesterolemiaD006937HP_0003124————22
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameERGOLOID MESYLATES
INN—
Description
Ergoloid mesylates (USAN), co-dergocrine mesilate (BAN) or dihydroergotoxine mesylate, trade name Hydergine, is a mixture of the methanesulfonate salts of three dihydrogenated ergot alkaloids (dihydroergocristine, dihydroergocornine, and alpha- and beta-dihydroergocryptine).
Classification
Small molecule
Drug class—
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
CC(C)C[C@H]1C(=O)N2CCC[C@H]2[C@]2(O)O[C@](NC(=O)[C@@H]3C[C@@H]4c5cccc6[nH]cc(c56)C[C@H]4N(C)C3)(C(C)C)C(=O)N12.CC(C)[C@@]1(NC(=O)[C@@H]2C[C@@H]3c4cccc5[nH]cc(c45)C[C@H]3N(C)C2)O[C@@]2(O)[C@@H]3CCCN3C(=O)[C@H](Cc3ccccc3)N2C1=O.CC(C)[C@H]1C(=O)N2CCC[C@H]2[C@]2(O)O[C@](NC(=O)[C@@H]3C[C@@H]4c5cccc6[nH]cc(c56)C[C@H]4N(C)C3)(C(C)C)C(=O)N12.CCC(C)[C@H]1C(=O)N2CCC[C@H]2[C@]2(O)O[C@](NC(=O)[C@@H]3C[C@@H]4c5cccc6[nH]cc(c56)C[C@H]4N(C)C3)(C(C)C)C(=O)N12.CS(=O)(=O)O.CS(=O)(=O)O.CS(=O)(=O)O.CS(=O)(=O)O
Identifiers
PDB—
CAS-ID8067-24-1
RxCUI—
ChEMBL IDCHEMBL2311030
ChEBI ID—
PubChem CID87068835
DrugBankDB01049
UNII ID—
Target
Agency Approved
No data
Alternate
No data
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 322 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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6,757 adverse events reported
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