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Ergoloid mesylates
Alkergot, Circanol, Deapril-st, Gerimal, Hydergine, Hydrogenated Ergot Alkaloids (ergoloid mesylates) is a small molecule pharmaceutical. Ergoloid mesylates was first approved as Hydergine on 1982-01-01.
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Therapeutic Areas
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Trade Name
FDA
EMA
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Drug Products
FDA
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New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Ergoloid mesylates
Tradename
Company
Number
Date
Products
HYDERGINENovartisN-009087 DISCN1982-01-01
2 products
HYDERGINENovartisN-017993 DISCN1982-01-01
2 products
HYDERGINENovartisN-018418 DISCN1982-01-01
1 products
HYDERGINE LCNovartisN-018706 DISCN1983-01-18
1 products
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Labels
FDA
EMA
Brand Name
Status
Last Update
ergoloid mesylatesANDA2017-11-22
Indications
FDA
EMA
No data
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
C: Cardiovascular system drugs
C04: Peripheral vasodilators
C04A: Peripheral vasodilators
C04AE: Ergot alkaloid peripheral vasodilators
C04AE01: Ergoloid mesylates
C04AE51: Ergoloid mesylates, combinations
HCPCS
No data
Clinical
Clinical Trials
1797 clinical trials
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Mock data
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Indications Phases 4
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Vitamin d deficiencyD014808EFO_0003762E5538614674251450
OsteoporosisD010024EFO_0003882M81.0919282129104
Covid-19D000086382U07.1361153458
ObesityD009765EFO_0001073E66.9263123255
Healthy volunteers/patients152322748
Chronic renal insufficiencyD051436N18256151945
Type 2 diabetes mellitusD003924EFO_0001360E11311791844
Metabolic bone diseasesD001851HP_0000938364101536
AsthmaD001249EFO_0000270J4549841134
Postmenopausal osteoporosisD015663EFO_00038544713933
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Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Breast neoplasmsD001943EFO_0003869C5081910436
Prostatic neoplasmsD011471C613126323
Hiv infectionsD015658EFO_0000764B20294215
Inflammatory bowel diseasesD015212EFO_0003767322915
Colorectal neoplasmsD015179172613
TuberculosisD014376EFO_0000774A15-A1932813
AgingD000375GO_0007568R41.81121811
PregnancyD011247EFO_0002950Z33.1113611
NeoplasmsD009369C80315210
Ulcerative colitisD003093EFO_0000729K51321510
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Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
HyperparathyroidismD006961EFO_0008506E21.31146
Bone densityD015519EFO_0003923M85145
Stress fracturesD015775M84.3145
AtherosclerosisD050197EFO_0003914I25.1145
Pre-eclampsiaD011225EFO_0000668O141145
Rectal neoplasmsD0120041124
Ovarian neoplasmsD010051EFO_0003893C561214
Female infertilityD007247EFO_0008560N97134
ArthralgiaD018771HP_0002829M25.5224
Hematopoietic stem cell transplantationD0183801134
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Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Nutritional statusD009752134
PeriodontitisD010518EFO_0000649K05.3134
Periodontal diseasesD010510K05.6134
Thyroid diseasesD013959HP_0000820E00-E07123
Tibial fracturesD013978EFO_0003944S82.20112
Morbid obesityD009767EFO_0001074112
GrowthD006128112
Breast densityD00007106011
Chronic progressive multiple sclerosisD02052811
Pituitary acth hypersecretionD047748EFO_1001110E24.011
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Indications Without Phase
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Wounds and injuriesD014947T14.833
Drug-related side effects and adverse reactionsD064420T88.733
Weight lossD015431HP_000182433
Diet therapyD00403522
HeadacheD006261HP_0002315R5122
Allergic rhinitisD065631J30.922
Vitamin k deficiencyD014813E56.122
Fracture healingD01710222
Female genital diseasesD005831EFO_0009549N8522
HypercholesterolemiaD006937HP_000312422
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameERGOLOID MESYLATES
INN
Description
Ergoloid mesylates (USAN), co-dergocrine mesilate (BAN) or dihydroergotoxine mesylate, trade name Hydergine, is a mixture of the methanesulfonate salts of three dihydrogenated ergot alkaloids (dihydroergocristine, dihydroergocornine, and alpha- and beta-dihydroergocryptine).
Classification
Small molecule
Drug class
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
CC(C)C[C@H]1C(=O)N2CCC[C@H]2[C@]2(O)O[C@](NC(=O)[C@@H]3C[C@@H]4c5cccc6[nH]cc(c56)C[C@H]4N(C)C3)(C(C)C)C(=O)N12.CC(C)[C@@]1(NC(=O)[C@@H]2C[C@@H]3c4cccc5[nH]cc(c45)C[C@H]3N(C)C2)O[C@@]2(O)[C@@H]3CCCN3C(=O)[C@H](Cc3ccccc3)N2C1=O.CC(C)[C@H]1C(=O)N2CCC[C@H]2[C@]2(O)O[C@](NC(=O)[C@@H]3C[C@@H]4c5cccc6[nH]cc(c56)C[C@H]4N(C)C3)(C(C)C)C(=O)N12.CCC(C)[C@H]1C(=O)N2CCC[C@H]2[C@]2(O)O[C@](NC(=O)[C@@H]3C[C@@H]4c5cccc6[nH]cc(c56)C[C@H]4N(C)C3)(C(C)C)C(=O)N12.CS(=O)(=O)O.CS(=O)(=O)O.CS(=O)(=O)O.CS(=O)(=O)O
Identifiers
PDB
CAS-ID8067-24-1
RxCUI
ChEMBL IDCHEMBL2311030
ChEBI ID
PubChem CID87068835
DrugBankDB01049
UNII ID
Target
Agency Approved
No data
Alternate
No data
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 322 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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6,757 adverse events reported
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