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Eptotermin alfa
Opgenra, Osigraft (eptotermin alfa) is a protein pharmaceutical. Eptotermin alfa was first approved as Osigraft on 2001-05-17. It has been approved in Europe to treat spondylolisthesis and tibial fractures. It is known to target bone morphogenetic protein receptor type-2.
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
musculoskeletal diseasesD009140
wounds and injuriesD014947
Trade Name
FDA
EMA
No data
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
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Labels
FDA
EMA
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Indications
FDA
EMA
No data
Agency Specific
FDA
EMA
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Patent Expiration
No data
ATC Codes
M: Musculo-skeletal system drugs
M05: Drugs for treatment of bone diseases
M05B: Drugs affecting bone structure and mineralization
M05BC: Bone morphogenetic proteins
M05BC02: Eptotermin alfa
HCPCS
No data
Clinical
Clinical Trials
11 clinical trials
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Mock data
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Indications Phases 4
No data
Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Alzheimer diseaseD000544EFO_0000249F03112
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Knee osteoarthritisD020370EFO_0004616M17213
Amyotrophic lateral sclerosisD000690EFO_0000253G12.2111
Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Healthy volunteers/patients22
Indications Without Phase
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Femur head necrosisD00527111
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameEPTOTERMIN ALFA
INNeptotermin alfa
Description
Bone morphogenetic protein 7 or BMP7 (also known as osteogenic protein-1 or OP-1) is a protein that in humans is encoded by the BMP7 gene.
Classification
Protein
Drug classgrowth factors: bone morphogenetic proteins; growth factors: transforming growth factors
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
Identifiers
PDB
CAS-ID
RxCUI
ChEMBL IDCHEMBL2108594
ChEBI ID
PubChem CID
DrugBank
UNII IDIT063R5MY0 (ChemIDplus, GSRS)
Target
Agency Approved
No data
Alternate
BMPR2
BMPR2
Organism
Homo sapiens
Gene name
BMPR2
Gene synonyms
PPH1
NCBI Gene ID
Protein name
bone morphogenetic protein receptor type-2
Protein synonyms
BMP type II receptor, BMP type-2 receptor, BMPR-II, Bone morphogenetic protein receptor type II, bone morphogenetic protein receptor, type II (serine/threonine kinase), type II activin receptor-like kinase, type II receptor for bone morphogenetic protein-4
Uniprot ID
Mouse ortholog
Bmpr2 (12168)
bone morphogenetic protein receptor type-2 (O35607)
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
Mock data
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Additional graphs summarizing 85 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
0 adverse events reported
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