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Ephedrine
Akovaz, Corphedra, Emerphed, Rezipres (ephedrine) is a small molecule pharmaceutical. Ephedrine was first approved as Akovaz on 2016-04-29. It is used to treat asthma, bronchial spasm, orthostatic hypotension, and rhinitis in the USA. The pharmaceutical is active against beta-2 adrenergic receptor.
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
infectionsD007239
respiratory tract diseasesD012140
otorhinolaryngologic diseasesD010038
nervous system diseasesD009422
cardiovascular diseasesD002318
immune system diseasesD007154
Trade Name
FDA
EMA
Akovaz, Corphedra, Emerphed, Rezipres (generic drugs available since 2017-08-23)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Ephedrine hydrochloride
Tradename
Company
Number
Date
Products
REZIPRESDr Reddys LaboratoriesN-213536 PEND2021-06-14
3 products, RLD
Ephedrine sulfate
Tradename
Company
Number
Date
Products
EPHEDRINE SULFATEAkornN-208609 RX2017-03-01
1 products
EPHEDRINE SULFATEEndoN-213994 RX2020-10-16
2 products, RLD, RS
AKOVAZExela Pharma SciencesN-208289 RX2016-04-29
2 products, RLD, RS
EMERPHEDNexus BiopharmaN-213407 RX2020-04-17
2 products, RLD, RS
CORPHEDRAPar PharmaceuticalN-208943 RX2017-01-27
1 products
Labels
FDA
EMA
Brand Name
Status
Last Update
akovazNew Drug Application2021-04-01
corphedraNew Drug Application2019-12-05
emerphedNew Drug Application2023-03-01
ephedrine sulfateANDA2023-03-31
rezipresNew Drug Application2021-08-01
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
asthmaEFO_0000270D001249J45
bronchial spasmD001986
orthostatic hypotensionD007024I95.1
rhinitisEFO_0008521D012220J31
Agency Specific
FDA
EMA
No data
Patent Expiration
Patent
Expires
Flag
FDA Information
Ephedrine Sulfate, Emerphed, Nexus Pharms
110902782040-05-16U-3183
112414002040-05-16U-3183
114647522040-05-16DP
114784362040-05-16U-3183
115713982040-05-16U-3183
Ephedrine Sulfate, Ephedrine Sulfate, Endo Ventures
108698452040-01-22DP
ATC Codes
A: Alimentary tract and metabolism drugs
A08: Antiobesity preparations, excl. diet products
A08A: Antiobesity preparations, excl. diet products
A08AA: Centrally acting antiobesity products
A08AA56: Ephedrine, combinations
C: Cardiovascular system drugs
C01: Cardiac therapy drugs
C01C: Cardiac stimulants excl. cardiac glycosides
C01CA: Adrenergic and dopaminergic cardiac stimulants
C01CA26: Ephedrine
R: Respiratory system drugs
R01: Nasal preparations
R01A: Decongestants and other nasal preparations for topical use
R01AA: Sympathomimetics, plain
R01AA03: Ephedrine
R01AB: Sympathomimetics, combinations excl. corticosteroids
R01AB05: Ephedrine
R03: Drugs for obstructive airway diseases
R03C: Adrenergics for systemic use
R03CA: Alpha- and beta-adrenoreceptor agonist, systemic drugs
R03CA02: Ephedrine
S: Sensory organ drugs
S01: Ophthalmologicals
S01F: Mydriatics and cycloplegics
S01FB: Sympathomimetics excl. antiglaucoma preparations
S01FB02: Ephedrine
HCPCS
No data
Clinical
Clinical Trials
104 clinical trials
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Indications Phases 4
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
HypotensionD007022EFO_0005251I953361121
Spinal anesthesiaD000775437
Pre-eclampsiaD011225EFO_0000668O141146
Cesarean sectionD0025851135
PregnancyD011247EFO_0002950Z33.133
Allergic rhinitisD065631J30.9123
BradycardiaD001919HP_0001662R00.122
BronchitisD001991J40112
CholelithiasisD002769EFO_0004799K8011
Low cardiac outputD00230311
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Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
ObesityD009765EFO_0001073E66.91146
AnesthesiaD000758112
InflammationD00724911
CoughD003371HP_0012735R0511
RhinitisD012220EFO_0008521J3111
Rapid sequence induction and intubationD00007960311
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
SinusitisD012852EFO_0007486J32123
Hiv infectionsD015658EFO_0000764B20112
PainD010146EFO_0003843R52111
Congenital myasthenic syndromesD020294Orphanet_590G70.2111
VomitingD014839HP_0002013R11.111
NauseaD009325HP_0002018R11.011
EnuresisD004775R3211
Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Healthy volunteers/patients9514
HypersensitivityD006967EFO_0003785T78.4022
HeadacheD006261HP_0002315R5111
FeverD005334HP_0001945R50.911
Acute painD059787R5211
Back painD001416HP_0003418M5411
Indications Without Phase
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Hip fracturesD006620EFO_0003964S72.0022
Blood pressureD001794EFO_000432522
Carotid endarterectomyD01689422
Morbid obesityD009767EFO_000107411
Compression fracturesD05081511
Allergic rhinitis seasonalD006255EFO_0003956J3011
Pregnancy rateD01887311
Body temperature changesD001832HP_000437011
Cardiovascular diseasesD002318EFO_0000319I9811
Type 2 diabetes mellitusD003924EFO_0001360E1111
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameEPHEDRINE
INN
Description
(-)-ephedrine is a phenethylamine alkaloid that is 2-phenylethanamine substituted by a methyl group at the amino nitrogen and a methyl and a hydroxy group at position 2 and 1 respectively. It has a role as a nasal decongestant, a sympathomimetic agent, a vasoconstrictor agent, a xenobiotic, an environmental contaminant, a plant metabolite and a bacterial metabolite. It is a member of phenylethanolamines and a phenethylamine alkaloid. It is a conjugate base of a (-)-ephedrinium.
Classification
Small molecule
Drug classsympathomimetics
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
CN[C@@H](C)[C@H](O)c1ccccc1
Identifiers
PDB
CAS-ID299-42-3
RxCUI3966
ChEMBL IDCHEMBL211456
ChEBI ID15407
PubChem CID9294
DrugBankDB01364
UNII ID
Target
Agency Approved
ADRB2
ADRB2
Organism
Homo sapiens
Gene name
ADRB2
Gene synonyms
ADRB2R, B2AR
NCBI Gene ID
Protein name
beta-2 adrenergic receptor
Protein synonyms
adrenergic, beta-2-, receptor, surface, adrenoceptor beta 2 surface, Beta-2 adrenoceptor, Beta-2 adrenoreceptor, catecholamine receptor
Uniprot ID
Mouse ortholog
Adrb2 (11555)
beta-2 adrenergic receptor (Q8BH38)
Alternate
No data
Variants
Clinical Variant
No data
Financial
Akovaz - Avadel Pharmaceuticals
$
£
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Tabular view
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 11,622 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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3 adverse events reported
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