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Epacadostat
Epacadostat is a small molecule pharmaceutical. It is currently being investigated in clinical studies. The pharmaceutical is active against indoleamine 2,3-dioxygenase 1.
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Commercial
Therapeutic Areas
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Trade Name
FDA
EMA
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Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
No data
Labels
FDA
EMA
No data
Indications
FDA
EMA
No data
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
L: Antineoplastic and immunomodulating agents
— L01: Antineoplastic agents
— L01X: Other antineoplastic agents in atc
— L01XX: Other antineoplastic agents in atc
— L01XX58: Epacadostat
HCPCS
No data
Clinical
Clinical Trials
60 clinical trials
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Indications Phases 4
No data
Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Head and neck neoplasmsD006258352——7
Lung neoplasmsD008175C34.90351——6
MelanomaD008545341——5
Renal cell carcinomaD002292111——2
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
NeoplasmsD009369C80149———14
Ovarian neoplasmsD010051EFO_0003893C5655———7
Fallopian tube neoplasmsD00518553———5
GlioblastomaD005909EFO_000051522———3
LymphomaD008223C85.933———3
Squamous cell carcinoma of head and neckD000077195—3———3
Colorectal neoplasmsD01517922———2
Endometrial neoplasmsD016889EFO_000423012———2
Pancreatic neoplasmsD010190EFO_0003860C25—2———2
Stomach neoplasmsD013274EFO_0003897C1612———2
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Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Non-small-cell lung carcinomaD0022893————3
RecurrenceD0120081————1
Hematologic neoplasmsD0193371————1
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameEPACADOSTAT
INNepacadostat
Description
Epacadostat (previously INCB24360) is an investigational drug for cancer. Epacadostat is an inhibitor of indoleamine 2,3-dioxygenase-1 (IDO1). Epacadostat inhibits IDO1 by competitively blocking it, without interfering with IDO2 or tryptophan 2,3-dioxygenase (TDO). It has antitumor activity in some models, though is most effective when combined with other immunotherapy agents.
Classification
Small molecule
Drug classenzyme inhibitors: indoleamine 2, 3-dioxygenase 1 (IDO1) inhibitors
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
NS(=O)(=O)NCCNc1nonc1/C(=N/O)Nc1ccc(F)c(Br)c1
Identifiers
PDB—
CAS-ID—
RxCUI—
ChEMBL IDCHEMBL3545369
ChEBI ID—
PubChem CID44608567
DrugBankDB11717
UNII ID71596A9R13 (ChemIDplus, GSRS)
Target
Agency Approved
IDO1
IDO1
Organism
Homo sapiens
Gene name
IDO1
Gene synonyms
IDO, INDO
NCBI Gene ID
3620
Protein name
indoleamine 2,3-dioxygenase 1
Protein synonyms
indolamine 2,3 dioxygenase, indole 2,3-dioxygenase, Indoleamine-pyrrole 2,3-dioxygenase
Uniprot ID
Q540B4
Mouse ortholog
Ido1 (15930)
indoleamine 2,3-dioxygenase 1 (P28776)
Alternate
No data
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 1,396 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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97 adverse events reported
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