Entinostat
Entinostat is a small molecule pharmaceutical. It is currently being investigated in clinical studies. It is known to target histone deacetylase 9, histone deacetylase 1, histone deacetylase 3, and histone deacetylase 2.
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Therapeutic Areas
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Trade Name
FDA
EMA
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Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
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Labels
FDA
EMA
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Indications
FDA
EMA
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Agency Specific
FDA
EMA
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Patent Expiration
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HCPCS
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Clinical
Clinical Trials
70 clinical trials
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Indications Phases 4
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Breast neoplasms | D001943 | EFO_0003869 | C50 | 12 | 8 | 2 | — | — | 20 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Non-small-cell lung carcinoma | D002289 | 7 | 7 | — | — | — | 11 | ||
| Neoplasms | D009369 | C80 | 9 | 2 | — | — | — | 9 | |
| Myeloid leukemia acute | D015470 | C92.0 | 2 | 3 | — | — | — | 5 | |
| Myelodysplastic syndromes | D009190 | D46 | 3 | 2 | — | — | — | 5 | |
| Kidney neoplasms | D007680 | EFO_0003865 | C64 | 4 | 2 | — | — | — | 4 |
| Triple negative breast neoplasms | D064726 | 2 | 2 | — | — | — | 4 | ||
| Precursor cell lymphoblastic leukemia-lymphoma | D054198 | C91.0 | 3 | 2 | — | — | — | 4 | |
| Pancreatic neoplasms | D010190 | EFO_0003860 | C25 | 3 | 2 | — | — | — | 4 |
| Lymphoma | D008223 | C85.9 | 3 | 2 | — | — | — | 4 | |
| Myelomonocytic leukemia chronic | D015477 | C93.1 | 1 | 2 | — | — | — | 3 |
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Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Healthy volunteers/patients | — | 4 | — | — | — | — | 4 | ||
| Lung neoplasms | D008175 | C34.90 | 3 | — | — | — | — | 3 | |
| Leukemia | D007938 | C95 | 2 | — | — | — | — | 2 | |
| Invasive hydatidiform mole | D002820 | D39.2 | 2 | — | — | — | — | 2 | |
| Digestive system neoplasms | D004067 | 2 | — | — | — | — | 2 | ||
| Lung diseases | D008171 | EFO_0003818 | J98.4 | 2 | — | — | — | — | 2 |
| Respiratory tract neoplasms | D012142 | EFO_0003853 | D14 | 2 | — | — | — | — | 2 |
| Bronchogenic carcinoma | D002283 | 2 | — | — | — | — | 2 | ||
| Thoracic neoplasms | D013899 | 2 | — | — | — | — | 2 | ||
| Neoplasms by histologic type | D009370 | 2 | — | — | — | — | 2 |
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Indications Without Phase
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | ENTINOSTAT |
| INN | entinostat |
| Description | Entinostat is a member of the class of benzamides resulting from the formal condensation of the carboxy group of the pyridin-3-ylmethyl carbamate derivative of p-(aminomethyl)benzoic acid with one of the amino groups of benzene-1,2-diamine. It is an inhibitor of histone deacetylase isoform 1 (HDAC1) and isoform 3 (HDAC3). It has a role as an EC 3.5.1.98 (histone deacetylase) inhibitor, an antineoplastic agent and an apoptosis inducer. It is a member of pyridines, a carbamate ester, a substituted aniline, a primary amino compound and a member of benzamides. It is functionally related to a 1,2-phenylenediamine. |
| Classification | Small molecule |
| Drug class | enzyme inhibitors: histone deacetylase inhibitors |
| Image (chem structure or protein) | |
| Structure (InChI/SMILES or Protein Sequence) | Nc1ccccc1NC(=O)c1ccc(CNC(=O)OCc2cccnc2)cc1 |
Identifiers
| PDB | — |
| CAS-ID | 209783-80-2 |
| RxCUI | — |
| ChEMBL ID | CHEMBL27759 |
| ChEBI ID | — |
| PubChem CID | 4261 |
| DrugBank | DB11841 |
| UNII ID | 1ZNY4FKK9H (ChemIDplus, GSRS) |
Target
Agency Approved
No data
Alternate
HDAC9
HDAC9
HDAC1
HDAC1
HDAC3
HDAC3
HDAC2
HDAC2
Organism
Homo sapiens
Gene name
HDAC9
Gene synonyms
HDAC7, HDAC7B, HDRP, KIAA0744, MITR
NCBI Gene ID
Protein name
histone deacetylase 9
Protein synonyms
HD7, HD7b, histone deacetylase 4/5-related protein, Histone deacetylase 7B, Histone deacetylase-related protein, MEF-2 interacting transcription repressor (MITR) protein, MEF2-interacting transcription repressor MITR
Uniprot ID
Mouse ortholog
Hdac9 (79221)
histone deacetylase 9 (Q99N13)
Variants
Clinical Variant
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Financial
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Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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116 adverse events reported
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