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Enoxacin
Penetrex (enoxacin) is a small molecule pharmaceutical. Enoxacin was first approved as Penetrex on 1991-12-31. It is used to treat escherichia coli infections, gonorrhea, haemophilus infections, klebsiella infections, and proteus infections amongst others in the USA. It is known to target V-type proton ATPase subunit B, brain isoform.
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
infectionsD007239
urogenital diseasesD000091642
Trade Name
FDA
EMA
No data
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Enoxacin
Tradename
Company
Number
Date
Products
PENETREXSanofiN-019616 DISCN1991-12-31
2 products
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Labels
FDA
EMA
Brand Name
Status
Last Update
penetrex(r) arthritis pain reliefunapproved drug other2022-06-20
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
escherichia coli infectionsEFO_1001318D004927B96.20
gonorrheaDOID_7551D006069A54
haemophilus infectionsEFO_1001127D006192—
klebsiella infectionsEFO_1001353D007710—
proteus infectionsEFO_1001130D011512—
pseudomonas infectionsEFO_0001076D011552—
staphylococcal infections—D013203A49.01
urinary tract infectionsEFO_0003103D014552N39.0
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
J: Antiinfectives for systemic use
— J01: Antibacterials for systemic use
— J01M: Quinolone antibacterials
— J01MA: Fluoroquinolone antibacterials, systemic
— J01MA04: Enoxacin
HCPCS
No data
Clinical
Clinical Trials
39 clinical trials
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Indications Phases 4
No data
Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Myeloid leukemia acuteD015470C92.013121—123
Myelodysplastic syndromesD009190D46241——7
Myeloid leukemiaD007951C92111——2
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Myelomonocytic leukemia chronicD015477C93.123———5
Hematologic neoplasmsD01933721———2
Multiple myelomaD009101C90.021———2
NeoplasmsD009369C8022———2
Biphenotypic leukemia acuteD015456C95.0—1———1
GliomaD005910EFO_000052011———1
CholangiocarcinomaD018281C22.111———1
ChondrosarcomaD00281311———1
LeukemiaD007938C9511———1
Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Healthy volunteers/patients—4————4
Hepatic insufficiencyD0485502————2
Prostatic neoplasmsD011471C611————1
Castration-resistant prostatic neoplasmsD0641291————1
Breast neoplasmsD001943EFO_0003869C501————1
Pancreatic neoplasmsD010190EFO_0003860C251————1
Non-hodgkin lymphomaD008228C85.91————1
Primary myelofibrosisD055728D47.41————1
Precursor cell lymphoblastic leukemia-lymphomaD054198C91.01————1
B-cell chronic lymphocytic leukemiaD015451C91.11————1
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Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameENOXACIN
INNenoxacin
Description
Enoxacin is a 1,8-naphthyridine derivative that is 1,4-dihydro-1,8-naphthyridine with an ethyl group at the 1 position, a carboxy group at the 3-position, an oxo sustituent at the 4-position, a fluoro substituent at the 5-position and a piperazin-1-yl group at the 7 position. An antibacterial, it is used in the treatment of urinary-tract infections and gonorrhoea. It has a role as an antibacterial drug and a DNA synthesis inhibitor. It is a monocarboxylic acid, an amino acid, a 1,8-naphthyridine derivative, a N-arylpiperazine, a quinolone antibiotic and a fluoroquinolone antibiotic.
Classification
Small molecule
Drug classantibacterials (quinolone derivatives)
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
CCn1cc(C(=O)O)c(=O)c2cc(F)c(N3CCNCC3)nc21
Identifiers
PDB—
CAS-ID74011-58-8
RxCUI3925
ChEMBL IDCHEMBL826
ChEBI ID157175
PubChem CID3229
DrugBankDB00467
UNII ID325OGW249P (ChemIDplus, GSRS)
Target
Agency Approved
No data
Alternate
ATP6V1B2
ATP6V1B2
Organism
Homo sapiens
Gene name
ATP6V1B2
Gene synonyms
ATP6B2, VPP3
NCBI Gene ID
526
Protein name
V-type proton ATPase subunit B, brain isoform
Protein synonyms
ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B2, Endomembrane proton pump 58 kDa subunit, H+ transporting two-sector ATPase, HO57, testicular secretory protein Li 65, V-ATPase B2 subunit, V-ATPase subunit B 2, vacuolar H+-ATPase 56,000 subunit, Vacuolar proton pump subunit B 2
Uniprot ID
Q96IR0
Mouse ortholog
Atp6v1b2 (11966)
V-type proton ATPase subunit B, brain isoform (Q3UAW7)
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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2,268 adverse events reported
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