Emricasan
Emricasan is a small molecule pharmaceutical. It is currently being investigated in clinical studies. It is known to target caspase-8.
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Commercial
Therapeutic Areas
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Trade Name
FDA
EMA
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Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
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Labels
FDA
EMA
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Indications
FDA
EMA
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Agency Specific
FDA
EMA
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Patent Expiration
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ATC Codes
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HCPCS
No data
Clinical
Clinical Trials
17 clinical trials
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Indications Phases 4
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Indications Phases 3
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Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Liver cirrhosis | D008103 | EFO_0001422 | K74.0 | — | 5 | — | — | 1 | 6 |
| Fibrosis | D005355 | — | 2 | — | — | 1 | 3 | ||
| Portal hypertension | D006975 | EFO_0000666 | K76.6 | — | 2 | — | — | 1 | 3 |
| Non-alcoholic fatty liver disease | D065626 | EFO_0003095 | K75.81 | — | 1 | — | — | 1 | 2 |
| Alcoholic fatty liver | D005235 | K70.0 | — | 2 | — | — | — | 2 | |
| Liver diseases | D008107 | EFO_0001421 | K70-K77 | 1 | 1 | — | — | — | 2 |
| Alcoholic hepatitis | D006519 | EFO_1001345 | K70.1 | — | 2 | — | — | — | 2 |
| Acute liver failure | D017114 | — | 1 | — | — | — | 1 | ||
| Acute-on-chronic liver failure | D065290 | — | 1 | — | — | — | 1 | ||
| Chronic hepatitis c | D019698 | EFO_0004220 | B18.2 | — | 1 | — | — | — | 1 |
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Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Covid-19 | D000086382 | U07.1 | 1 | — | — | — | — | 1 | |
| Hepatic insufficiency | D048550 | 1 | — | — | — | — | 1 | ||
| Digestive system diseases | D004066 | EFO_0000405 | K92.9 | 1 | — | — | — | — | 1 |
| Kidney diseases | D007674 | EFO_0003086 | N08 | 1 | — | — | — | — | 1 |
| Renal insufficiency | D051437 | HP_0000083 | N19 | 1 | — | — | — | — | 1 |
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | EMRICASAN |
| INN | emricasan |
| Description | Emricasan (IDN-6556, PF-03491390) is a potential drug invented in 1998 by Idun Pharmaceuticals. The drug was acquired by Pfizer in 2005 and then sold to Conatus Pharmaceuticals in 2010. Conatus in turn licensed emricasan to Novartis in 2017 for exclusive development and commercialization.
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| Classification | Small molecule |
| Drug class | caspase inhibitors |
| Image (chem structure or protein) | |
| Structure (InChI/SMILES or Protein Sequence) | C[C@H](NC(=O)C(=O)Nc1ccccc1C(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)COc1c(F)c(F)cc(F)c1F |
Identifiers
| PDB | — |
| CAS-ID | 254750-02-2 |
| RxCUI | — |
| ChEMBL ID | CHEMBL197672 |
| ChEBI ID | — |
| PubChem CID | 12000240 |
| DrugBank | DB05408 |
| UNII ID | P0GMS9N47Q (ChemIDplus, GSRS) |
Target
Agency Approved
No data
Alternate
CASP8
CASP8
Organism
Homo sapiens
Gene name
CASP8
Gene synonyms
MCH5
NCBI Gene ID
Protein name
caspase-8
Protein synonyms
Apoptotic cysteine protease, Apoptotic protease Mch-5, CAP4, caspase 8, apoptosis-related cysteine peptidase, caspase 8, apoptosis-related cysteine protease, FADD-homologous ICE/CED-3-like protease, FADD-like ICE, FLICE, ICE-like apoptotic protease 5, MACH, MACH-alpha-1/2/3 protein, MACH-beta-1/2/3/4 protein, MORT1-associated ced-3 homolog
Uniprot ID
Mouse ortholog
Casp8 (12370)
caspase-8 (O89110)
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 589 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
0 adverse events reported
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