Emapunil
Emapunil is a small molecule pharmaceutical. It is currently being investigated in clinical studies. The pharmaceutical is active against translocator protein.
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Commercial
Therapeutic Areas
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Trade Name
FDA
EMA
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Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
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Labels
FDA
EMA
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Indications
FDA
EMA
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Agency Specific
FDA
EMA
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Patent Expiration
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ATC Codes
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HCPCS
No data
Clinical
Clinical Trials
4 clinical trials
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Indications Phases 4
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Indications Phases 3
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Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Anxiety disorders | D001008 | EFO_0006788 | F41.1 | — | 1 | — | — | — | 1 |
Indications Phases 1
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Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Multiple sclerosis | D009103 | EFO_0003885 | G35 | — | — | — | — | 1 | 1 |
| Neurodegenerative diseases | D019636 | EFO_0005772 | G31.9 | — | — | — | — | 1 | 1 |
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | EMAPUNIL |
| INN | emapunil |
| Description | Emapunil (AC-5216, XBD-173) is an anxiolytic drug which acts as a selective agonist at the peripheral benzodiazepine receptor, also known as the mitochondrial 18 kDa translocator protein or TSPO. This protein has multiple functions, among which is regulation of steroidogenesis, particularly the production of neuroactive steroids such as allopregnanolone in the brain. In both animal and human trials, emapunil produced fast acting anxiolytic and anti-panic effects, without producing sedation or withdrawal symptoms following cessation of use. Emapunil is also used in its 11C radiolabelled form to map the distribution of TSPO receptors in the brain.
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| Classification | Small molecule |
| Drug class | mitochondrial benzodiazepine receptor (MBR) selective, partial, or inverse agonists (purine derivatives) |
| Image (chem structure or protein) | |
| Structure (InChI/SMILES or Protein Sequence) | CCN(Cc1ccccc1)C(=O)Cn1c(=O)n(C)c2cnc(-c3ccccc3)nc21 |
Identifiers
| PDB | — |
| CAS-ID | 226954-04-7 |
| RxCUI | — |
| ChEMBL ID | CHEMBL513922 |
| ChEBI ID | — |
| PubChem CID | 6433109 |
| DrugBank | DB12666 |
| UNII ID | OG837L732J (ChemIDplus, GSRS) |
Target
Agency Approved
TSPO
TSPO
Organism
Homo sapiens
Gene name
TSPO
Gene synonyms
BZRP, MBR
NCBI Gene ID
Protein name
translocator protein
Protein synonyms
benzodiazepine peripheral binding site, Mitochondrial benzodiazepine receptor, PBR, Peripheral-type benzodiazepine receptor, PKBS
Uniprot ID
Mouse ortholog
Tspo (12257)
translocator protein (Q99M32)
Alternate
No data
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 35 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
0 adverse events reported
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