Eltoprazine
Eltoprazine is a small molecule pharmaceutical. It is currently being investigated in clinical studies.
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Abbreviated New Drug Application (ANDA)
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Clinical
Clinical Trials
2 clinical trials
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Indications Phases 4
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Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Parkinson disease | D010300 | EFO_0002508 | G20 | — | 1 | — | — | — | 1 |
| Dyskinesias | D020820 | G24 | — | 1 | — | — | — | 1 | |
| Schizophrenia | D012559 | EFO_0000692 | F20 | — | 1 | — | — | — | 1 |
| Cognitive dysfunction | D060825 | G31.84 | — | 1 | — | — | — | 1 |
Indications Phases 1
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Indications Without Phase
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | ELTOPRAZINE |
| INN | eltoprazine |
| Description | Eltoprazine (developmental code name DU-28,853) is a serotonergic drug of the phenylpiperazine class which is described as a serenic or antiaggressive agent. It acts as an agonist of the serotonin 5-HT1A and 5-HT1B receptors and as an antagonist of the serotonin 5-HT2C receptor. The drug is closely related to fluprazine and batoprazine, which are similarly acting agents, and is also a known chemical precursor to S-15535 and lecozotan. Eltoprazine is or was under development for the treatment of aggression, attention deficit hyperactivity disorder (ADHD), cognition disorders, and drug-induced dyskinesia, but no recent development has been reported for these indications as of February 2022. It was also under development for the treatment of psychotic disorders, but development for this indication was discontinued. Eltoprazine was originated by Solvay and was developed by Elto Pharma, PsychoGenics, and Solvay.
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| Classification | Small molecule |
| Drug class | — |
| Image (chem structure or protein) | |
| Structure (InChI/SMILES or Protein Sequence) | c1cc2c(c(N3CCNCC3)c1)OCCO2 |
Identifiers
| PDB | — |
| CAS-ID | 98224-03-4 |
| RxCUI | — |
| ChEMBL ID | CHEMBL282614 |
| ChEBI ID | — |
| PubChem CID | 65853 |
| DrugBank | DB12883 |
| UNII ID | 510M006KO6 (ChemIDplus, GSRS) |
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