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Eletriptan
Relpax (eletriptan) is a small molecule pharmaceutical. Eletriptan was first approved as Relpax on 2002-12-26. It is used to treat migraine disorders in the USA. The pharmaceutical is active against 5-hydroxytryptamine receptor 1F, 5-hydroxytryptamine receptor 1B, and 5-hydroxytryptamine receptor 1D. In addition, it is known to target 5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine receptor 1E.
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
nervous system diseasesD009422
Trade Name
FDA
EMA
Relpax (generic drugs available since 2017-06-16)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Eletriptan hydrobromide
Tradename
Company
Number
Date
Products
RELPAXUpjohnN-021016 RX2002-12-26
2 products, RLD, RS
Labels
FDA
EMA
Brand Name
Status
Last Update
eletriptanNDA authorized generic2021-07-08
relpaxNew Drug Application2020-04-06
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
migraine disordersEFO_0003821D008881G43
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
N: Nervous system drugs
— N02: Analgesics
— N02C: Antimigraine preparations
— N02CC: Selective serotonin (5ht1) agonists
— N02CC06: Eletriptan
HCPCS
No data
Clinical
Clinical Trials
1 clinical trials
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Indications Phases 4
No data
Indications Phases 3
No data
Indications Phases 2
No data
Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Autonomic nervous system diseasesD001342EFO_0009532G901————1
Orthostatic hypotensionD007024I95.11————1
Orthostatic intoleranceD0549711————1
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameELETRIPTAN
INNeletriptan
Description
Eletriptan is an N-alkylpyrrolidine, that is N-methylpyrrolidine in which the pro-R hydrogen at position 2 is replaced by a {5-[2-(phenylsulfonyl)ethyl]-1H-indol-3-yl}methyl group. It has a role as a serotonergic agonist, a vasoconstrictor agent and a non-steroidal anti-inflammatory drug. It is a member of indoles, a N-alkylpyrrolidine and a sulfone. It is a conjugate base of an eletriptan(1+).
Classification
Small molecule
Drug classantimigraine agents (5-HT1 receptor agonists); sumatriptan derivatives
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
CN1CCC[C@@H]1Cc1c[nH]c2ccc(CCS(=O)(=O)c3ccccc3)cc12
Identifiers
PDB—
CAS-ID143322-58-1
RxCUI231049
ChEMBL IDCHEMBL1510
ChEBI ID50922
PubChem CID77993
DrugBankDB00216
UNII ID22QOO9B8KI (ChemIDplus, GSRS)
Target
Agency Approved
HTR1F
HTR1F
HTR1B
HTR1B
HTR1D
HTR1D
Organism
Homo sapiens
Gene name
HTR1F
Gene synonyms
HTR1EL
NCBI Gene ID
3355
Protein name
5-hydroxytryptamine receptor 1F
Protein synonyms
5-hydroxytryptamine (serotonin) receptor 1F, G protein-coupled, Serotonin receptor 1F
Uniprot ID
P30939
Mouse ortholog
Htr1f (15557)
5-hydroxytryptamine receptor 1F (Q02284)
Alternate
HTR1A
HTR1A
HTR1E
HTR1E
Organism
Homo sapiens
Gene name
HTR1A
Gene synonyms
ADRB2RL1, ADRBRL1
NCBI Gene ID
3350
Protein name
5-hydroxytryptamine receptor 1A
Protein synonyms
5-HT1a receptor, 5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled, G-21, guanine nucleotide-binding regulatory protein-coupled receptor, Serotonin receptor 1A
Uniprot ID
Q6LAE7
Mouse ortholog
Htr1a (15550)
5-hydroxytryptamine receptor 1A (Q8BGS4)
Variants
Clinical Variant
No data
Financial
Relpax - Pfizer
$
€
£
₣
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Tabular view
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 596 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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15 adverse events reported
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