Dyphylline
Dilor, Lufyllin, Neothylline (dyphylline) is a small molecule pharmaceutical. Dyphylline was first approved as Neothylline on 1982-01-01. It is used to treat asthma and bronchitis in the USA.
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EMA
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Drug Products
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Labels
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Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| asthma | EFO_0000270 | D001249 | J45 |
| bronchitis | — | D001991 | J40 |
Agency Specific
FDA
EMA
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Patent Expiration
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ATC Codes
R: Respiratory system drugs
— R03: Drugs for obstructive airway diseases
— R03D: Other systemic drugs for obstructive airway diseases in atc
— R03DA: Xanthines, systemic for obstructive airway disease
— R03DA01: Diprophylline
— R03DA51: Diprophylline, combinations
— R03DB: Xanthines and adrenergics
— R03DB01: Diprophylline and adrenergics
HCPCS
Code | Description |
|---|---|
| J1180 | Injection, dyphylline, up to 500 mg |
Clinical
Clinical Trials
57 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Female infertility | D007247 | EFO_0008560 | N97 | — | — | 3 | 3 | 1 | 7 |
| Infertility | D007246 | EFO_0000545 | — | — | 1 | 2 | 4 | 7 | |
| Premature obstetric labor | D007752 | O60 | — | 1 | — | 1 | 1 | 3 | |
| Threatened abortion | D000033 | O20.0 | — | — | — | 1 | 1 | 2 | |
| Leiomyoma | D007889 | HP_0000131 | D25 | — | — | — | 1 | — | 1 |
| Menopause | D008593 | EFO_0003922 | N95 | — | — | — | 1 | — | 1 |
| Female genital diseases | D005831 | EFO_0009549 | N85 | — | — | — | 1 | — | 1 |
| Male genital diseases | D005832 | EFO_0009555 | N50.9 | — | — | — | 1 | — | 1 |
| Hormone replacement therapy | D020249 | EFO_0003961 | Z79.890 | — | — | — | 1 | — | 1 |
| Male infertility | D007248 | EFO_0004248 | N46 | — | — | — | 1 | — | 1 |
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Spontaneous abortion | D000022 | EFO_1001255 | O00.1 | — | 1 | 2 | — | 1 | 3 |
| Postmenopause | D017698 | — | — | 2 | — | — | 2 | ||
| Endometrial hyperplasia | D004714 | N85.0 | — | — | 1 | — | — | 1 | |
| Premature birth | D047928 | EFO_0003917 | O60 | — | 1 | 1 | — | — | 1 |
| Pregnancy | D011247 | EFO_0002950 | Z33.1 | — | — | 1 | — | — | 1 |
Indications Phases 2
No data
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Endometriosis | D004715 | EFO_0001065 | N80 | — | — | — | — | 3 | 3 |
| Polycystic ovary syndrome | D011085 | EFO_0000660 | E28.2 | — | — | — | — | 1 | 1 |
| Oocyte donation | D018587 | — | — | — | — | 1 | 1 | ||
| Kallmann syndrome | D017436 | Orphanet_478 | E23.0 | — | — | — | — | 1 | 1 |
| Hemophilia b | D002836 | D67 | — | — | — | — | 1 | 1 |
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | DYPHYLLINE |
| INN | diprophylline |
| Description | Dyphylline is an oxopurine that is theophylline bearing a 2,3-dihydroxypropyl group at the 7 position. It has broncho- and vasodilator properties, and is used in the treatment of asthma, cardiac dyspnea, and bronchitis. It is also an ingredient in preparations that have been promoted for coughs. It has a role as a bronchodilator agent, a vasodilator agent, an EC 3.1.4.* (phosphoric diester hydrolase) inhibitor and a muscle relaxant. It is an oxopurine and a member of propane-1,2-diols. |
| Classification | Small molecule |
| Drug class | — |
| Image (chem structure or protein) | |
| Structure (InChI/SMILES or Protein Sequence) | Cn1c(=O)c2c(ncn2CC(O)CO)n(C)c1=O |
Identifiers
| PDB | — |
| CAS-ID | 479-18-5 |
| RxCUI | — |
| ChEMBL ID | CHEMBL1752 |
| ChEBI ID | 4728 |
| PubChem CID | 3182 |
| DrugBank | DB00651 |
| UNII ID | 263T0E9RR9 (ChemIDplus, GSRS) |
Target
Agency Approved
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Alternate
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Variants
Clinical Variant
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Financial
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Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 351 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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162 adverse events reported
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