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Dydrogesterone
Gynorest (dydrogesterone) is a small molecule pharmaceutical. Dydrogesterone was first approved as Gynorest on 1982-01-01. It is used to treat menstruation disturbances in the USA. The pharmaceutical is active against progesterone receptor.
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
signs and symptoms pathological conditionsD013568
Trade Name
FDA
EMA
No data
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Dydrogesterone
Tradename
Company
Number
Date
Products
GYNORESTSolvay PharmaceuticalsN-017388 DISCN1982-01-01
2 products, RLD
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Labels
FDA
EMA
No data
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
menstruation disturbancesHP_0400007D008599N91.5
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
G: Genito urinary system and sex hormones
— G03: Sex hormones and modulators of the genital system
— G03D: Progestogen sex hormones and modulators of the genital system
— G03DB: Pregnadien derivatives, progestogens
— G03DB01: Dydrogesterone
— G03F: Progestogens and estrogens in combination
— G03FA: Progestogens and estrogens, fixed combinations
— G03FA14: Dydrogesterone and estrogen
— G03FB: Progestogens and estrogens, sequential preparations
— G03FB08: Dydrogesterone and estrogen
HCPCS
No data
Clinical
Clinical Trials
22 clinical trials
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Indications Phases 4
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Postoperative nausea and vomitingD020250EFO_0004888—11125
Hallux valgusD006215HP_0001822———112
VomitingD014839HP_0002013R11.1———2—2
CholecystolithiasisD041761EFO_1000864———1—1
Dental care for disabledD003730———1—1
NauseaD009325HP_0002018R11.0———1—1
Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
PainD010146EFO_0003843R52——1——1
Psychomotor agitationD011595——1——1
Indications Phases 2
No data
Indications Phases 1
No data
Indications Without Phase
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
SchizophreniaD012559EFO_0000692F20————11
Postoperative painD010149G89.18————11
Inguinal herniaD006552HP_0000023K40————11
Migraine disordersD008881EFO_0003821G43————11
Cardiac arrhythmiasD001145EFO_0004269I49.9————11
Female genital diseasesD005831EFO_0009549N85————11
Urologic diseasesD014570N39.9————11
Digestive system diseasesD004066EFO_0000405K92.9————11
Orthopedic proceduresD019637————11
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameDYDROGESTERONE
INNdydrogesterone
Description
Dydrogesterone is a 3-oxo-Delta(4) steroid and a 20-oxo steroid. It has a role as a progestin.
Classification
Small molecule
Drug classprogestins; steroids (androgens, anabolics); antiandrogens
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
CC(=O)[C@H]1CC[C@H]2[C@@H]3C=CC4=CC(=O)CC[C@@]4(C)[C@@H]3CC[C@]12C
Identifiers
PDB—
CAS-ID152-62-5
RxCUI3706
ChEMBL IDCHEMBL1200853
ChEBI ID31527
PubChem CID9051
DrugBankDB00378
UNII ID90I02KLE8K (ChemIDplus, GSRS)
Target
Agency Approved
PGR
PGR
Organism
Homo sapiens
Gene name
PGR
Gene synonyms
NR3C3
NCBI Gene ID
5241
Protein name
progesterone receptor
Protein synonyms
Nuclear receptor subfamily 3 group C member 3
Uniprot ID
Q9UPF7
Mouse ortholog
Pgr (18667)
progesterone receptor (Q00175)
Alternate
No data
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 1,364 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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901 adverse events reported
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