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Dubermatinib
Dubermatinib is a small molecule pharmaceutical. It is currently being investigated in clinical studies. It is known to target aurora kinase A, aurora kinase B, and tyrosine-protein kinase receptor UFO.
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Commercial
Therapeutic Areas
No data
Trade Name
FDA
EMA
No data
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
No data
Labels
FDA
EMA
No data
Indications
FDA
EMA
No data
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
No data
HCPCS
No data
Clinical
Clinical Trials
4 clinical trials
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Mock data
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Indications Phases 4
No data
Indications Phases 3
No data
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Myeloid leukemia acuteD015470C92.021———2
B-cell chronic lymphocytic leukemiaD015451C91.111———1
Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Colorectal neoplasmsD0151791————1
Ovarian neoplasmsD010051EFO_0003893C561————1
NeoplasmsD009369C801————1
Non-small-cell lung carcinomaD0022891————1
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameDUBERMATINIB
INNdubermatinib
Description
Dubermatinib is a small molecule pharmaceutical. It is currently being investigated in clinical studies. It is known to target aurora kinase A, aurora kinase B, and tyrosine-protein kinase receptor UFO.
Classification
Small molecule
Drug classtyrosine kinase inhibitors
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
CN1CCN(Cc2ccc(Nc3ncc(Cl)c(Nc4ccccc4S(=O)(=O)N(C)C)n3)cc2)CC1
Identifiers
PDB—
CAS-ID1341200-45-0
RxCUI—
ChEMBL IDCHEMBL2022968
ChEBI ID—
PubChem CID—
DrugBank—
UNII ID14D65TV20J (ChemIDplus, GSRS)
Target
Agency Approved
No data
Alternate
AURKA
AURKA
AURKB
AURKB
AXL
AXL
Organism
Homo sapiens
Gene name
AURKA
Gene synonyms
AIK, AIRK1, ARK1, AURA, AYK1, BTAK, IAK1, STK15, STK6
NCBI Gene ID
6790
Protein name
aurora kinase A
Protein synonyms
ARK-1, Aurora 2, Aurora-related kinase 1, aurora/IPL1-like kinase, Aurora/IPL1-related kinase 1, Breast tumor-amplified kinase, Ipl1- and aurora-related kinase 1, protein phosphatase 1, regulatory subunit 47, serine/threonine protein kinase 15, Serine/threonine-protein kinase 15, Serine/threonine-protein kinase 6, Serine/threonine-protein kinase aurora-A, Serine/threonine-protein kinase Ayk1
Uniprot ID
Q9UPG5
Mouse ortholog
Aurka (20878)
aurora kinase A (Q91YU4)
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 20 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
0 adverse events reported
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