Doxycycline anhydrous
Monodox, Oracea, Vibramycin (doxycycline anhydrous) is a small molecule pharmaceutical. Doxycycline anhydrous was first approved as Vibramycin on 1982-01-01. It is used to treat anthrax, bacterial pneumonia, campylobacter infections, cholera, and granuloma inguinale amongst others in the USA.
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Commercial
Therapeutic Areas
Therapeutic Area | MeSH |
|---|---|
| infections | D007239 |
| respiratory tract diseases | D012140 |
| eye diseases | D005128 |
| urogenital diseases | D000091642 |
| skin and connective tissue diseases | D017437 |
Trade Name
FDA
EMA
Monodox, Oracea, Vibramycin (generic drugs available since 1988-03-09, discontinued: Doxychel)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Doxycycline
Doxycycline calcium
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| VIBRAMYCIN | Mylan | N-050480 RX | 1982-01-01 | 1 products, RLD, RS |
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| doxycycline | ANDA | 2023-06-13 |
| monodox | New Drug Application | 2017-04-26 |
| oracea | New Drug Application | 2017-08-01 |
| vibra-tabs vibramycin calcium vibramycin hyclate vibramycin monohydrate | New Drug Application | 2021-07-29 |
Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| anthrax | — | D000881 | A22 |
| bacterial pneumonia | EFO_1001272 | D018410 | J15.9 |
| campylobacter infections | EFO_0007190 | D002169 | — |
| cholera | — | D002771 | A00 |
| granuloma inguinale | EFO_0007291 | D006100 | A58 |
| mycoplasma infections | — | D009175 | — |
| plague | EFO_0007481 | D010930 | A20 |
| pleural effusion | — | D010996 | J90 |
| psittacosis | EFO_0007410 | D009956 | A70 |
| relapsing fever | — | D012061 | A68 |
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Agency Specific
FDA
EMA
No data
ATC Codes
A: Alimentary tract and metabolism drugs
— A01: Stomatological preparations
— A01A: Stomatological preparations
— A01AB: Antiinfectives and antiseptics for local oral treatment
— A01AB22: Doxycycline
J: Antiinfectives for systemic use
— J01: Antibacterials for systemic use
— J01A: Tetracycline antibiotics
— J01AA: Tetracyclines
— J01AA02: Doxycycline
HCPCS
No data
Clinical
Clinical Trials
316 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Acne vulgaris | D000152 | EFO_0003894 | L70 | 3 | 6 | 4 | 8 | 1 | 19 |
| Rosacea | D012393 | L71 | 3 | 1 | 4 | 8 | 1 | 17 | |
| Covid-19 | D000086382 | U07.1 | 1 | 3 | 5 | 3 | 2 | 13 | |
| Infections | D007239 | EFO_0000544 | — | — | — | 6 | 4 | 10 | |
| Periodontal diseases | D010510 | K05.6 | — | 3 | 2 | 2 | 3 | 9 | |
| Chlamydia infections | D002690 | EFO_0007205 | A74.9 | — | 1 | 2 | 5 | — | 8 |
| Chronic obstructive pulmonary disease | D029424 | EFO_0000341 | J44.9 | — | — | 2 | 3 | 1 | 6 |
| Syphilis | D013587 | EFO_0007504 | A53.9 | — | — | 2 | 4 | — | 6 |
| Lyme disease | D008193 | A69.2 | — | — | 2 | 2 | 1 | 5 | |
| Erythema chronicum migrans | D015787 | A26.0 | — | — | — | 1 | 4 | 5 |
Show 51 more
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Amyloidosis | D000686 | EFO_1001875 | E85 | 1 | 3 | 1 | — | 1 | 4 |
| Chronic periodontitis | D055113 | EFO_0006343 | K05.3 | — | 3 | 2 | — | — | 4 |
| Graves ophthalmopathy | D049970 | EFO_1001466 | 1 | 3 | 1 | — | 1 | 4 | |
| Filarial elephantiasis | D004605 | EFO_0007272 | B74.0 | — | — | 3 | — | — | 3 |
| Lymphedema | D008209 | Q82.0 | — | — | 3 | — | — | 3 | |
| Filariasis | D005368 | B74 | — | — | 3 | — | — | 3 | |
| Tuberculosis | D014376 | EFO_0000774 | A15-A19 | — | 2 | 1 | — | — | 3 |
| Heart failure | D006333 | EFO_0003144 | I50 | — | 1 | 1 | — | — | 2 |
| Ventricular remodeling | D020257 | — | 1 | 1 | — | — | 2 | ||
| St elevation myocardial infarction | D000072657 | — | 1 | 1 | — | — | 2 |
Show 22 more
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Colorectal neoplasms | D015179 | — | 2 | — | — | 1 | 3 | ||
| Ulcerative colitis | D003093 | EFO_0000729 | K51 | — | 2 | — | — | 1 | 3 |
| Pelvic inflammatory disease | D000292 | EFO_1001388 | N70-N77 | — | 1 | — | — | 1 | 2 |
| Non-small-cell lung carcinoma | D002289 | — | 1 | — | — | 1 | 2 | ||
| Anthrax | D000881 | A22 | 1 | 1 | — | — | — | 2 | |
| Pancreatic neoplasms | D010190 | EFO_0003860 | C25 | — | 1 | — | — | 1 | 2 |
| Breast neoplasms | D001943 | EFO_0003869 | C50 | 1 | 1 | — | — | — | 2 |
| T-cell lymphoma cutaneous | D016410 | C84.A | 1 | 1 | — | — | — | 2 | |
| Atopic dermatitis | D003876 | EFO_0000274 | L20 | — | 2 | — | — | — | 2 |
| Mansonelliasis | D008368 | EFO_0007357 | B74.4 | — | 2 | — | — | — | 2 |
Show 57 more
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Healthy volunteers/patients | — | 6 | — | — | — | 2 | 8 | ||
| Therapeutic equivalency | D013810 | 5 | — | — | — | — | 5 | ||
| Tennis elbow | D013716 | EFO_1001896 | M77.1 | 1 | — | — | — | 1 | 2 |
| Arteriovenous malformations | D001165 | 2 | — | — | — | — | 2 | ||
| Elbow tendinopathy | D000070639 | M77.0 | 1 | — | — | — | — | 1 | |
| Coronavirus infections | D018352 | EFO_0007224 | B34.2 | 1 | — | — | — | — | 1 |
| Severe acute respiratory syndrome-related coronavirus | D045473 | NCBITaxon_227859 | 1 | — | — | — | — | 1 | |
| Cardio-renal syndrome | D059347 | 1 | — | — | — | — | 1 | ||
| Intracranial aneurysm | D002532 | EFO_0003870 | I67.1 | 1 | — | — | — | — | 1 |
| Cavernous hemangioma | D006392 | D18.0 | 1 | — | — | — | — | 1 |
Show 6 more
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Tick-borne encephalitis | D004675 | EFO_1001309 | A84 | — | — | — | — | 2 | 2 |
| Rheumatoid arthritis | D001172 | EFO_0000685 | M06.9 | — | — | — | — | 2 | 2 |
| Malaria | D008288 | EFO_0001068 | B54 | — | — | — | — | 1 | 1 |
| Mycoplasma pneumonia | D011019 | EFO_0007387 | J15.7 | — | — | — | — | 1 | 1 |
| Aseptic meningitis | D008582 | EFO_1000823 | G03.0 | — | — | — | — | 1 | 1 |
| Staphylococcus aureus | D013211 | NCBITaxon_1280 | — | — | — | — | 1 | 1 | |
| Female infertility | D007247 | EFO_0008560 | N97 | — | — | — | — | 1 | 1 |
| Liver cirrhosis | D008103 | EFO_0001422 | K74.0 | — | — | — | — | 1 | 1 |
| Infertility | D007246 | EFO_0000545 | — | — | — | — | 1 | 1 | |
| Diet therapy | D004035 | — | — | — | — | 1 | 1 |
Show 23 more
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | DOXYCYCLINE ANHYDROUS |
| INN | doxycycline |
| Description | Doxycycline is tetracycline in which the 5beta-hydrogen is replaced by a hydroxy group, while the 6alpha-hydroxy group is replaced by hydrogen. A semi-synthetic tetracycline antibiotic, it is used to inhibit bacterial protein synthesis and treat non-gonococcal urethritis and cervicitis, exacerbations of bronchitis in patients with chronic obstructive pulmonary disease (COPD), and adult periodontitis. It has a role as an antibacterial drug, an antimalarial, a geroprotector, an anti-inflammatory agent and an immunomodulator. |
| Classification | Small molecule |
| Drug class | antibiotics (tetracycline derivatives) |
| Image (chem structure or protein) | |
| Structure (InChI/SMILES or Protein Sequence) | C[C@H]1c2cccc(O)c2C(=O)C2=C(O)[C@]3(O)C(=O)C(C(N)=O)=C(O)[C@@H](N(C)C)[C@@H]3[C@@H](O)[C@@H]21 |
Identifiers
| PDB | — |
| CAS-ID | 564-25-0 |
| RxCUI | 1545992 |
| ChEMBL ID | CHEMBL1433 |
| ChEBI ID | 50845 |
| PubChem CID | 54671203 |
| DrugBank | DB00254 |
| UNII ID | 334895S862 (ChemIDplus, GSRS) |
Target
Agency Approved
No data
Alternate
No data
Variants
Clinical Variant
No data
Financial
Doxycycline - Fortress Biotech, Inc.
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Doxycycline - Journey Medical
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Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 72,122 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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16,260 adverse events reported
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