Doxercalciferol
Hectorol (doxercalciferol) is a small molecule pharmaceutical. Doxercalciferol was first approved as Hectorol on 1999-06-09. It is used to treat hyperparathyroidism in the USA. It is known to target vitamin D3 receptor and vitamin D 25-hydroxylase.
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Commercial
Therapeutic Areas
Therapeutic Area | MeSH |
|---|---|
| endocrine system diseases | D004700 |
Trade Name
FDA
EMA
Hectorol (generic drugs available since 2013-08-30)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| hectorol | New Drug Application | 2018-12-04 |
Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| hyperparathyroidism | EFO_0008506 | D006961 | E21.3 |
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
HCPCS
Code | Description |
|---|---|
| J1270 | Injection, doxercalciferol, 1 mcg |
Clinical
Clinical Trials
68 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Glaucoma | D005901 | EFO_0000516 | H40 | 1 | 2 | 8 | 14 | 5 | 30 |
| Ocular hypertension | D009798 | EFO_1001069 | H40.0 | — | 1 | 8 | 16 | 2 | 27 |
| Open-angle glaucoma | D005902 | EFO_0004190 | H40.1 | — | 2 | 4 | 17 | 2 | 24 |
| Exfoliation syndrome | D017889 | EFO_0004235 | — | — | — | 1 | 1 | 2 | |
| Eye diseases | D005128 | EFO_0003966 | H44 | — | — | — | 1 | — | 1 |
| Retinal degeneration | D012162 | HP_0001105 | — | — | — | 1 | — | 1 |
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Macular edema | D008269 | — | 2 | 1 | — | 1 | 3 | ||
| Macular degeneration | D008268 | EFO_0001365 | H35.30 | — | 2 | 1 | — | — | 2 |
| Wet macular degeneration | D057135 | EFO_0004683 | — | 2 | 1 | — | — | 2 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Retinal vein occlusion | D012170 | EFO_1001157 | H34.81 | — | 1 | — | — | — | 1 |
Indications Phases 1
No data
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Diabetic retinopathy | D003930 | EFO_0003770 | — | — | — | — | 2 | 2 | |
| Retinoschisis | D041441 | H33.10 | — | — | — | — | 1 | 1 | |
| Low tension glaucoma | D057066 | EFO_1001022 | H40.12 | — | — | — | — | 1 | 1 |
| Scleral buckling | D012591 | — | — | — | — | 1 | 1 | ||
| Retinal detachment | D012163 | EFO_0005773 | H33.2 | — | — | — | — | 1 | 1 |
| Retinal perforations | D012167 | EFO_1001028 | — | — | — | — | 1 | 1 |
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | DOXERCALCIFEROL |
| INN | doxercalciferol |
| Description | Doxercalciferol is a hydroxy seco-steroid and synthetic vitamin D2 analogue that undergoes metabolic activation in vivo to form 1alpha,25-dihydroxyvitamin D2 (1alpha,25-(OH)2D2), a naturally occurring, biologically active form of vitamin D2. It is used to treat secondary hyperparathyroidism, a condition in which the body produces excess parathyroid hormone (PTH; a natural substance needed to control the amount of calcium in the blood) in certain people with chronic kidney disease. It has a role as a provitamin, a bone density conservation agent and a prohormone. It is a vitamin D and a hydroxy seco-steroid. |
| Classification | Small molecule |
| Drug class | vitamin D analogs |
| Image (chem structure or protein) | |
| Structure (InChI/SMILES or Protein Sequence) | C=C1/C(=C\C=C2/CCC[C@@]3(C)[C@H]2CC[C@@H]3[C@H](C)/C=C/[C@H](C)C(C)C)C[C@@H](O)C[C@@H]1O |
Identifiers
| PDB | 3DL9 |
| CAS-ID | 54573-75-0 |
| RxCUI | 11516 |
| ChEMBL ID | CHEMBL1200810 |
| ChEBI ID | 4712 |
| PubChem CID | 5281107 |
| DrugBank | DB06410 |
| UNII ID | 3DIZ9LF5Y9 (ChemIDplus, GSRS) |
Target
Agency Approved
No data
Alternate
VDR
VDR
CYP2R1
CYP2R1
Organism
Homo sapiens
Gene name
VDR
Gene synonyms
NR1I1
NCBI Gene ID
Protein name
vitamin D3 receptor
Protein synonyms
1,25-dihydroxyvitamin D3 receptor, Nuclear receptor subfamily 1 group I member 1, protein phosphatase 1, regulatory subunit 163, vitamin D (1,25- dihydroxyvitamin D3) receptor
Uniprot ID
Mouse ortholog
Vdr (22337)
vitamin D3 receptor (Q922X0)
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 544 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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8,137 adverse events reported
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