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Dovitinib
Dovitinib is a small molecule pharmaceutical. It is currently being investigated in clinical studies. The pharmaceutical is active against receptor-type tyrosine-protein kinase FLT3. In addition, it is known to target fibroblast growth factor receptor 1, macrophage colony-stimulating factor 1 receptor, vascular endothelial growth factor receptor 1, mast/stem cell growth factor receptor Kit, vascular endothelial growth factor receptor 3, epidermal growth factor receptor, fibroblast growth factor receptor 3, platelet-derived growth factor receptor beta, vascular endothelial growth factor receptor 2, platelet-derived growth factor receptor alpha, and insulin receptor.
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Commercial
Therapeutic Areas
No data
Trade Name
FDA
EMA
No data
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
No data
Labels
FDA
EMA
No data
Indications
FDA
EMA
No data
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
No data
HCPCS
No data
Clinical
Clinical Trials
57 clinical trials
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Mock data
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Indications Phases 4
No data
Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
NeoplasmsD009369C801021——12
Renal cell carcinomaD002292111——3
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Breast neoplasmsD001943EFO_0003869C5044———7
Stomach neoplasmsD013274EFO_0003897C1623———4
Pancreatic neoplasmsD010190EFO_0003860C2522———4
Multiple myelomaD009101C90.021———3
Colorectal neoplasmsD01517912———3
Non-small-cell lung carcinomaD00228912———3
Gastrointestinal stromal tumorsD046152EFO_0000505C49.A12———3
Adenoid cystic carcinomaD003528—3———3
GlioblastomaD005909EFO_000051511———2
Prostatic neoplasmsD011471C61—2———2
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Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Pancreatic ductal carcinomaD0214411————1
Hepatic insufficiencyD0485501————1
Myeloid leukemia acuteD015470C92.01————1
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameDOVITINIB
INNdovitinib
Description
4-amino-5-fluoro-3-[5-(4-methyl-1-piperazinyl)-1,3-dihydrobenzimidazol-2-ylidene]-2-quinolinone is a N-arylpiperazine.
Classification
Small molecule
Drug classtyrosine kinase inhibitors
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
CN1CCN(c2ccc3nc(-c4c(N)c5c(F)cccc5[nH]c4=O)[nH]c3c2)CC1
Identifiers
PDB—
CAS-ID1027263-12-2
RxCUI—
ChEMBL IDCHEMBL522892
ChEBI ID—
PubChem CID135398510
DrugBank—
UNII IDI35H55G906 (ChemIDplus, GSRS)
Target
Agency Approved
FLT3
FLT3
Organism
Homo sapiens
Gene name
FLT3
Gene synonyms
CD135, FLK2, STK1
NCBI Gene ID
2322
Protein name
receptor-type tyrosine-protein kinase FLT3
Protein synonyms
CD135, CD135 antigen, fetal liver kinase 2, Fetal liver kinase-2, FL cytokine receptor, FLK-2, FLT-3, fms related tyrosine kinase 3, Fms-like tyrosine kinase 3, growth factor receptor tyrosine kinase type III, Stem cell tyrosine kinase 1, STK-1
Uniprot ID
Q13414
Mouse ortholog
Flt3 (14255)
receptor-type tyrosine-protein kinase FLT3 (Q00342)
Alternate
FGFR1
FGFR1
CSF1R
CSF1R
FLT1
FLT1
KIT
KIT
FLT4
FLT4
EGFR
EGFR
FGFR3
FGFR3
PDGFRB
PDGFRB
KDR
KDR
PDGFRA
PDGFRA
INSR
INSR
Organism
Homo sapiens
Gene name
FGFR1
Gene synonyms
BFGFR, CEK, FGFBR, FLG, FLT2, HBGFR
NCBI Gene ID
2260
Protein name
fibroblast growth factor receptor 1
Protein synonyms
Basic fibroblast growth factor receptor 1, bFGF-R-1, BFGFR, CD331, FGFR1/PLAG1 fusion, FLT-2, FMS-like tyrosine kinase 2, fms-related tyrosine kinase 2, heparin-binding growth factor receptor, hydroxyaryl-protein kinase, N-sam, Proto-oncogene c-Fgr
Uniprot ID
P11362
Mouse ortholog
Fgfr1 (14182)
fibroblast growth factor receptor 1 (P16092)
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
Mock data
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Additional graphs summarizing 1,612 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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49 adverse events reported
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