Doconexent
Doconexent is a small molecule pharmaceutical. It is currently being investigated in clinical studies. It is known to target free fatty acid receptor 1, transient receptor potential cation channel subfamily A member 1, retinoic acid receptor RXR-alpha, and potassium channel subfamily K member 10.
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New Drug Application (NDA)
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Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
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Labels
FDA
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Brand Name | Status | Last Update |
|---|---|---|
| citranatal medley | unapproved drug other | 2023-03-23 |
Indications
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Agency Specific
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Clinical
Clinical Trials
335 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Inflammation | D007249 | — | 3 | 2 | 2 | 5 | 12 | ||
| Major depressive disorder | D003865 | EFO_0003761 | F22 | — | 3 | 2 | 1 | 5 | 10 |
| Hypertriglyceridemia | D015228 | EFO_0004211 | — | — | 3 | 3 | 3 | 9 | |
| Attention deficit disorder with hyperactivity | D001289 | EFO_0003888 | F90 | — | 2 | 1 | 1 | 4 | 8 |
| Coronary artery disease | D003324 | I25.1 | — | 1 | 1 | 2 | 3 | 7 | |
| Bipolar disorder | D001714 | EFO_0000289 | F30.9 | — | 4 | — | 2 | 1 | 7 |
| Type 2 diabetes mellitus | D003924 | EFO_0001360 | E11 | — | — | — | 2 | 4 | 6 |
| Autism spectrum disorder | D000067877 | F84.0 | — | 3 | — | 2 | 1 | 6 | |
| Schizophrenia | D012559 | EFO_0000692 | F20 | — | 3 | 2 | 2 | 1 | 6 |
| Psychotic disorders | D011618 | F20.81 | — | 4 | 1 | 1 | — | 5 |
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Breast neoplasms | D001943 | EFO_0003869 | C50 | 3 | 7 | 1 | — | 8 | 19 |
| Healthy volunteers/patients | — | 2 | — | 2 | — | 12 | 16 | ||
| Depression | D003863 | F33.9 | — | 2 | 3 | — | 3 | 8 | |
| Metabolic syndrome | D024821 | EFO_0000195 | E88.81 | 1 | 1 | 1 | — | 5 | 8 |
| Cardiovascular diseases | D002318 | EFO_0000319 | I98 | — | 2 | 4 | — | 2 | 7 |
| Neoplasms | D009369 | C80 | 1 | 1 | 3 | — | 2 | 6 | |
| Obesity | D009765 | EFO_0001073 | E66.9 | — | 1 | 2 | — | 3 | 5 |
| Hypercholesterolemia | D006937 | HP_0003124 | — | 1 | 2 | — | 1 | 4 | |
| Dry eye syndromes | D015352 | H04.12 | — | — | 1 | — | 3 | 4 | |
| Sarcopenia | D055948 | EFO_1000653 | M62.84 | 1 | — | 1 | — | 2 | 4 |
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Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Cystic fibrosis | D003550 | EFO_0000390 | E84 | — | 2 | — | — | 2 | 4 |
| Insulin resistance | D007333 | EFO_0002614 | — | 1 | — | — | 2 | 3 | |
| Ductal carcinoma breast | D018270 | — | 3 | — | — | — | 3 | ||
| Precursor cell lymphoblastic leukemia-lymphoma | D054198 | C91.0 | — | 2 | — | — | — | 2 | |
| Type 1 diabetes mellitus | D003922 | EFO_0001359 | E10 | 1 | 1 | — | — | 1 | 2 |
| Multiple sclerosis | D009103 | EFO_0003885 | G35 | 2 | 1 | — | — | — | 2 |
| Necrotizing enterocolitis | D020345 | EFO_0003928 | K55.3 | 1 | 1 | — | — | 1 | 2 |
| Sickle cell anemia | D000755 | EFO_0000697 | D57 | — | 2 | — | — | — | 2 |
| Myeloid leukemia chronic-phase | D015466 | 1 | 1 | — | — | — | 1 | ||
| Periodontitis | D010518 | EFO_0000649 | K05.3 | — | 1 | — | — | — | 1 |
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Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Macular degeneration | D008268 | EFO_0001365 | H35.30 | 1 | — | — | — | 3 | 4 |
| Brain concussion | D001924 | S06.0 | 1 | — | — | — | 1 | 2 | |
| Parkinson disease | D010300 | EFO_0002508 | G20 | 1 | — | — | — | — | 1 |
| Facial pain | D005157 | R51.9 | 1 | — | — | — | — | 1 | |
| Infertility | D007246 | EFO_0000545 | 1 | — | — | — | — | 1 | |
| Pregnancy | D011247 | EFO_0002950 | Z33.1 | 1 | — | — | — | — | 1 |
| Oligospermia | D009845 | N46.1 | 1 | — | — | — | — | 1 | |
| Colitis | D003092 | EFO_0003872 | K52.9 | 1 | — | — | — | — | 1 |
| Sclerosing cholangitis | D015209 | EFO_0004268 | K83.01 | 1 | — | — | — | — | 1 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Menopause | D008593 | EFO_0003922 | N95 | — | — | — | — | 3 | 3 |
| Prostatic neoplasms | D011471 | C61 | — | — | — | — | 3 | 3 | |
| Bone density | D015519 | EFO_0003923 | M85 | — | — | — | — | 2 | 2 |
| Body composition | D001823 | — | — | — | — | 2 | 2 | ||
| Cognitive dysfunction | D060825 | G31.84 | — | — | — | — | 2 | 2 | |
| Muscle weakness | D018908 | HP_0001324 | — | — | — | — | 2 | 2 | |
| Depressive disorder | D003866 | EFO_1002014 | F32.A | — | — | — | — | 2 | 2 |
| Hot flashes | D019584 | — | — | — | — | 2 | 2 | ||
| Ulcerative colitis | D003093 | EFO_0000729 | K51 | — | — | — | — | 2 | 2 |
| Rheumatoid arthritis | D001172 | EFO_0000685 | M06.9 | — | — | — | — | 2 | 2 |
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | DOCONEXENT |
| INN | doconexent |
| Description | All-cis-docosa-4,7,10,13,16,19-hexaenoic acid is a docosahexaenoic acid having six cis-double bonds at positions 4, 7, 10, 13, 16 and 19. It has a role as a nutraceutical, an antineoplastic agent, a human metabolite, a Daphnia tenebrosa metabolite, a mouse metabolite and an algal metabolite. It is a docosahexaenoic acid and an omega-3 fatty acid. It is a conjugate acid of a (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate. |
| Classification | Small molecule |
| Drug class | — |
| Image (chem structure or protein) | |
| Structure (InChI/SMILES or Protein Sequence) | CC/C=C\C/C=C\C/C=C\C/C=C\C/C=C\C/C=C\CCC(=O)O |
Identifiers
| PDB | 1MV9 |
| CAS-ID | 6217-54-5 |
| RxCUI | 144450 |
| ChEMBL ID | CHEMBL367149 |
| ChEBI ID | 28125 |
| PubChem CID | 445580 |
| DrugBank | DB03756 |
| UNII ID | ZAD9OKH9JC (ChemIDplus, GSRS) |
Target
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Additional graphs summarizing 25 documents
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Safety
Black-box Warning
Black-box warning for: Citranatal medley
Adverse Events
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693 adverse events reported
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