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Dipyridamole
Aggrenox, Persantine (dipyridamole) is a small molecule pharmaceutical. Dipyridamole was first approved as Persantine on 1986-12-22. The pharmaceutical is active against equilibrative nucleoside transporter 1. In addition, it is known to target high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A, high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B, cAMP-specific 3',5'-cyclic phosphodiesterase 7B, equilibrative nucleoside transporter 4, and heat shock protein HSP 90-alpha.
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Commercial
Therapeutic Areas
No data
Trade Name
FDA
EMA
Persantine (generic drugs available since 1990-10-03)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Aspirin
+
Dipyridamole
Tradename
Company
Number
Date
Products
AGGRENOXBoehringer IngelheimN-020884 DISCN1999-11-22
1 products, RLD
Hide discontinued
Dipyridamole
Tradename
Company
Number
Date
Products
PERSANTINEBoehringer IngelheimN-012836 RX1986-12-22
3 products, RLD
Show 1 discontinued
Labels
FDA
EMA
Brand Name
Status
Last Update
aggrenoxNew Drug Application2016-08-06
aspirin-dipyridamoleANDA2023-05-15
Indications
FDA
EMA
No data
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
B: Blood and blood forming organ drugs
— B01: Antithrombotic agents
— B01A: Antithrombotic agents
— B01AC: Platelet aggregation inhibitors excl. heparin
— B01AC07: Dipyridamole
HCPCS
Code
Description
G9531
Patient has documentation of ventricular shunt, brain tumor, multisystem trauma, or is currently taking an antiplatelet medication including: abciximab, anagrelide, cangrelor, cilostazol, clopidogrel, dipyridamole, eptifibatide, prasugrel, ticlopidine, ticagrelor, tirofiban, or vorapaxar
J1245
Injection, dipyridamole, per 10 mg
Clinical
Clinical Trials
92 clinical trials
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Mock data
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Indications Phases 4
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Induced laborD007751—458825
Cervical ripeningD020070——75416
PregnancyD011247EFO_0002950Z33.1——2147
Premature rupture fetal membranesD005322HP_0001788O421112—4
ContraceptionD003267——11—2
Intrauterine devicesD007434——11—2
Uterine myomectomyD063186——11—2
Obstetric labor complicationsD007744—1—1—2
Obstetric laborD007743———112
HysteroscopyD015907———1—1
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Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Labor painD048949——1——1
HysterectomyD007044EFO_0003881——1——1
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Pre-eclampsiaD011225EFO_0000668O1411———1
Fetal deathD005313HP_000382611———1
Incomplete abortionD000027EFO_1001799—1———1
Missed abortionD000030O02.1—1———1
Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Diabetic retinopathyD003930EFO_00037701————1
Fetal growth retardationD005317EFO_00004951————1
Indications Without Phase
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
HeadacheD006261HP_0002315R51————22
Pregnancy rateD018873————22
Female infertilityD007247EFO_0008560N97————11
Liver cirrhosisD008103EFO_0001422K74.0————11
Acute-on-chronic liver failureD065290————11
ObesityD009765EFO_0001073E66.9————11
Migraine disordersD008881EFO_0003821G43————11
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameDIPYRIDAMOLE
INNdipyridamole
Description
Dipyridamole is a pyrimidopyrimidine that is 2,2',2'',2'''-(pyrimido[5,4-d]pyrimidine-2,6-diyldinitrilo)tetraethanol substituted by piperidin-1-yl groups at positions 4 and 8 respectively. A vasodilator agent, it inhibits the formation of blood clots. It has a role as an adenosine phosphodiesterase inhibitor, an EC 3.5.4.4 (adenosine deaminase) inhibitor, a platelet aggregation inhibitor and a vasodilator agent. It is a member of piperidines, a pyrimidopyrimidine, a tertiary amino compound and a tetrol.
Classification
Small molecule
Drug class—
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
OCCN(CCO)c1nc(N2CCCCC2)c2nc(N(CCO)CCO)nc(N3CCCCC3)c2n1
Identifiers
PDB7DMC
CAS-ID58-32-2
RxCUI3521
ChEMBL IDCHEMBL932
ChEBI ID4653
PubChem CID3108
DrugBankDB00975
UNII ID64ALC7F90C (ChemIDplus, GSRS)
Target
Agency Approved
SLC29A1
SLC29A1
Organism
Homo sapiens
Gene name
SLC29A1
Gene synonyms
ENT1
NCBI Gene ID
2030
Protein name
equilibrative nucleoside transporter 1
Protein synonyms
Equilibrative NBMPR-sensitive nucleoside transporter, equilibrative nitrobenzylmercaptopurine riboside (NBMPR)-sensitive nucleoside transporter, Equilibrative nitrobenzylmercaptopurine riboside-sensitive nucleoside transporter, es nucleoside transporter, Nucleoside transporter, es-type, solute carrier family 29 (equilibrative nucleoside transporter), member 1, solute carrier family 29 (nucleoside transporters), member 1, Solute carrier family 29 member 1
Uniprot ID
Q9UJY2
Mouse ortholog
Slc29a1 (63959)
equilibrative nucleoside transporter 1 (Q9JIM1)
Alternate
PDE8A
PDE8A
PDE8B
PDE8B
PDE7B
PDE7B
SLC29A4
SLC29A4
HSP90AA1
HSP90AA1
Organism
Homo sapiens
Gene name
PDE8A
Gene synonyms
NCBI Gene ID
5151
Protein name
high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A
Protein synonyms
cAMP-specific cyclic nucleotide phosphodiesterase 8A
Uniprot ID
O60658
Mouse ortholog
Pde8a (18584)
high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A (Q059P6)
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
Mock data
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Additional graphs summarizing 11,064 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
Mock data
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1,025 adverse events reported
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