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Dipraglurant
Dipraglurant is a small molecule pharmaceutical. It is currently being investigated in clinical studies. It is known to target metabotropic glutamate receptor 5.
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Commercial
Therapeutic Areas
No data
Trade Name
FDA
EMA
No data
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
No data
Labels
FDA
EMA
No data
Indications
FDA
EMA
No data
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
No data
HCPCS
No data
Clinical
Clinical Trials
5 clinical trials
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Mock data
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Indications Phases 4
No data
Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Parkinson diseaseD010300EFO_0002508G20323
DyskinesiasD020820G24222
Drug-induced dyskinesiaD004409EFO_1000904222
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
DystoniaD004421HP_0001332G2411
BlepharospasmD001764G24.511
Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Healthy volunteers/patients11
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameDIPRAGLURANT
INNdipraglurant
Description
Dipraglurant (INN) (code name ADX-48621) is a negative allosteric modulator of the mGlu5 receptor which is under development by Addex Therapeutics for the treatment of Parkinson's disease levodopa-induced dyskinesia (PD-LID). As of 2014, it is in phase II clinical trials for this indication. Addex Therapeutics is also investigating an extended-release formulation of dipraglurant for the treatment of non-parkinsonian dystonia.
Classification
Small molecule
Drug classmetabotropic glutamate receptor antagonists, negative allosteric modulators
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
Fc1ccc2nc(CCC#Cc3ccccn3)cn2c1
Identifiers
PDB
CAS-ID872363-17-2
RxCUI
ChEMBL IDCHEMBL2346738
ChEBI ID
PubChem CID44557636
DrugBankDB12733
UNII IDCV8JZR21A1 (ChemIDplus, GSRS)
Target
Agency Approved
No data
Alternate
GRM5
GRM5
Organism
Homo sapiens
Gene name
GRM5
Gene synonyms
GPRC1E, MGLUR5
NCBI Gene ID
Protein name
metabotropic glutamate receptor 5
Protein synonyms
glutamate receptor, metabotropic 5, protein phosphatase 1, regulatory subunit 86
Uniprot ID
Mouse ortholog
Grm5 (108071)
metabotropic glutamate receptor 5 (Q3UVX5)
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 61 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
0 adverse events reported
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