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Dicyclomine
Bentyl (dicyclomine) is a small molecule pharmaceutical. Dicyclomine was first approved as Dicyclomine hydrochloride on 1982-01-01. It is used to treat irritable bowel syndrome in the USA. The pharmaceutical is active against muscarinic acetylcholine receptor M1 and muscarinic acetylcholine receptor M3. In addition, it is known to target muscarinic acetylcholine receptor M2 and muscarinic acetylcholine receptor M4.
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
digestive system diseasesD004066
Trade Name
FDA
EMA
Bentyl (generic drugs available since 1982-01-01)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Dicyclomine hydrochloride
Tradename
Company
Number
Date
Products
BENTYLAbbVieN-008370 RX1984-10-15
1 products, RLD, RS
BENTYL PRESERVATIVE FREEAbbVieN-008370 RX1984-10-15
1 products, RLD, RS
Show 2 discontinued
Labels
FDA
EMA
Brand Name
Status
Last Update
bentylNew Drug Application2023-02-04
dicyclomine hydrochlorideANDA2023-06-07
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
irritable bowel syndromeEFO_0000555D043183K58
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
A: Alimentary tract and metabolism drugs
A03: Drugs for functional gastrointestinal disorders
A03A: Drugs for functional gastrointestinal disorders
A03AA: Synthetic anticholinergics, esters with tertiary amino group for functional gastrointestinal disorders
A03AA07: Dicycloverine
HCPCS
Code
Description
J0500
Injection, dicyclomine hcl, up to 20 mg
Clinical
Clinical Trials
7 clinical trials
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Indications Phases 4
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
EndocarditisD004696EFO_0000465I3322
OsteomyelitisD010019EFO_0003102M8611
Infectious arthritisD001170EFO_1001351M0011
Atopic dermatitisD003876EFO_0000274L2011
Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Bacterial infectionsD001424A4911
BacteremiaD016470EFO_0003033R78.8111
Gram-positive bacterial infectionsD01690811
Indications Phases 2
No data
Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Healthy volunteers/patients22
Drug interactionsD00434711
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameDICYCLOMINE
INNdicycloverine
Description
Dicyclomine is the ester resulting from the formal condensation of 1-cyclohexylcyclohexanecarboxylic acid with 2-(diethylamino)ethanol. An anticholinergic, it is used as the hydrochloride to treat or prevent spasm in the muscles of the gastrointestinal tract, particularly that associated with irritable bowel syndrome. It has a role as a muscarinic antagonist, an antispasmodic drug and a parasympatholytic. It is a tertiary amine and a carboxylic ester. It is functionally related to a 2-diethylaminoethanol and a 1,1'-bi(cyclohexyl)-1-carboxylic acid.
Classification
Small molecule
Drug class
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
CCN(CC)CCOC(=O)C1(C2CCCCC2)CCCCC1
Identifiers
PDB
CAS-ID77-19-0
RxCUI3361
ChEMBL IDCHEMBL1123
ChEBI ID4514
PubChem CID3042
DrugBankDB00804
UNII ID4KV4X8IF6V (ChemIDplus, GSRS)
Target
Agency Approved
CHRM1
CHRM1
CHRM3
CHRM3
Organism
Homo sapiens
Gene name
CHRM1
Gene synonyms
NCBI Gene ID
Protein name
muscarinic acetylcholine receptor M1
Protein synonyms
acetylcholine receptor, muscarinic 1
Uniprot ID
Mouse ortholog
Chrm1 (12669)
muscarinic acetylcholine receptor M1 (Q8BJN3)
Alternate
CHRM2
CHRM2
CHRM4
CHRM4
Organism
Homo sapiens
Gene name
CHRM2
Gene synonyms
NCBI Gene ID
Protein name
muscarinic acetylcholine receptor M2
Protein synonyms
7TM receptor, acetylcholine receptor, muscarinic 2, muscarinic M2 receptor
Uniprot ID
Mouse ortholog
Chrm2 (243764)
muscarinic acetylcholine receptor M2 (Q9ERZ4)
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 977 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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307 adverse events reported
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