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Dicumarol
Dicumarol is a small molecule pharmaceutical. Dicumarol was first approved as Dicumarol on 1982-01-01. It is used to treat pulmonary embolism, thromboembolism, and venous thrombosis in the USA. The pharmaceutical is active against vitamin K epoxide reductase complex subunit 1.
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
respiratory tract diseasesD012140
cardiovascular diseasesD002318
Trade Name
FDA
EMA
No data
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Dicumarol
Tradename
Company
Number
Date
Products
DICUMAROLAbbVieN-005545 DISCN1982-01-01
3 products
DICUMAROLEli LillyN-005509 DISCN1982-01-01
2 products
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Labels
FDA
EMA
No data
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
pulmonary embolismEFO_0003827D011655I26
thromboembolismHP_0001907D013923—
venous thrombosisHP_0004936D020246I82.40
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
B: Blood and blood forming organ drugs
— B01: Antithrombotic agents
— B01A: Antithrombotic agents
— B01AA: Vitamin k antagonists
— B01AA01: Dicoumarol
HCPCS
No data
Clinical
Clinical Trials
2 clinical trials
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Indications Phases 4
No data
Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Hyperkalemic periodic paralysisD020513G72.3——2——2
Hypokalemic periodic paralysisD020514G72.3——2——2
Myotonic disordersD020967Orphanet_606G71.1——1——1
Indications Phases 2
No data
Indications Phases 1
No data
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameDICUMAROL
INNdicoumarol
Description
Dicoumarol is a hydroxycoumarin that is methane in which two hydrogens have each been substituted by a 4-hydroxycoumarin-3-yl group. Related to warfarin, it has been used as an anticoagulant. It has a role as a vitamin K antagonist, an anticoagulant, an EC 1.6.5.2 [NAD(P)H dehydrogenase (quinone)] inhibitor and a Hsp90 inhibitor.
Classification
Small molecule
Drug classanticoagulants (dicumarol type)
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
O=c1oc2ccccc2c(O)c1Cc1c(O)c2ccccc2oc1=O
Identifiers
PDB—
CAS-ID66-76-2
RxCUI1598
ChEMBL IDCHEMBL1466
ChEBI ID4513
PubChem CID54676038
DrugBankDB00266
UNII ID7QID3E7BG7 (ChemIDplus, GSRS)
Target
Agency Approved
VKORC1
VKORC1
Organism
Homo sapiens
Gene name
VKORC1
Gene synonyms
VKOR
NCBI Gene ID
79001
Protein name
vitamin K epoxide reductase complex subunit 1
Protein synonyms
phylloquinone epoxide reductase, vitamin K dependent clotting factors deficiency 2, Vitamin K1 2,3-epoxide reductase subunit 1, vitamin K1 epoxide reductase (warfarin-sensitive)
Uniprot ID
Q9BQB6
Mouse ortholog
Vkorc1 (27973)
vitamin K epoxide reductase complex subunit 1 (Q9CRC0)
Alternate
No data
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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1,321 adverse events reported
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