Diazoxide
Proglycem (diazoxide) is a small molecule pharmaceutical. Diazoxide was first approved as Hyperstat on 1982-01-01. It is used to treat hypoglycemia and malignant hypertension in the USA. It is known to target ATP-sensitive inward rectifier potassium channel 8, ATP-sensitive inward rectifier potassium channel 11, and nicotinamide phosphoribosyltransferase.
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Commercial
Trade Name
FDA
EMA
Proglycem (generic drugs available since 2019-12-20, discontinued: Hyperstat)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Diazoxide
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| PROGLYCEM | Teva | N-017453 RX | 1982-01-01 | 1 products, RLD, RS |
Show 2 discontinued
Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| hypoglycemia | HP_0001943 | D007003 | E16.2 |
| malignant hypertension | EFO_1001031 | D006974 | — |
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
C: Cardiovascular system drugs
— C02: Antihypertensives
— C02D: Arteriolar smooth muscle, agents acting on
— C02DA: Thiazide derivatives acting on arteriolar smooth muscle
— C02DA01: Diazoxide
V: Various drug classes in atc
— V03: All other therapeutic products
— V03A: All other therapeutic products
— V03AH: Drugs for treatment of hypoglycemia
— V03AH01: Diazoxide
HCPCS
Code | Description |
|---|---|
| J1730 | Injection, diazoxide, up to 300 mg |
Clinical
Clinical Trials
25 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Type 1 diabetes mellitus | D003922 | EFO_0001359 | E10 | — | — | — | 3 | 1 | 4 |
| Type 2 diabetes mellitus | D003924 | EFO_0001360 | E11 | — | 3 | — | 1 | — | 4 |
| Glucose metabolism disorders | D044882 | — | 3 | — | 1 | — | 4 | ||
| Hypoglycemia | D007003 | HP_0001943 | E16.2 | — | 1 | 1 | 1 | — | 2 |
| Neuroendocrine tumors | D018358 | EFO_1001901 | D3A.8 | — | — | — | 1 | — | 1 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Hypertriglyceridemia | D015228 | EFO_0004211 | 3 | 2 | — | — | — | 5 | |
| Obesity | D009765 | EFO_0001073 | E66.9 | — | 4 | — | — | — | 4 |
| Hyperinsulinism | D006946 | HP_0000842 | E16.1 | 1 | 1 | — | — | — | 2 |
| Dyslipidemias | D050171 | HP_0003119 | — | 1 | — | — | — | 1 | |
| Prader-willi syndrome | D011218 | Orphanet_739 | Q87.11 | — | 1 | — | — | — | 1 |
| Depression | D003863 | F33.9 | 1 | 1 | — | — | — | 1 |
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Myocardial stunning | D017682 | 1 | — | — | — | — | 1 | ||
| Prediabetic state | D011236 | EFO_1001121 | R73.03 | 1 | — | — | — | — | 1 |
| Insulin resistance | D007333 | EFO_0002614 | 1 | — | — | — | — | 1 | |
| Non-alcoholic fatty liver disease | D065626 | EFO_0003095 | K75.81 | 1 | — | — | — | — | 1 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Reperfusion injury | D015427 | — | — | — | — | 1 | 1 |
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | DIAZOXIDE |
| INN | diazoxide |
| Description | Diazoxide is a benzothiadiazine that is the S,S-dioxide of 2H-1,2,4-benzothiadiazine which is substituted at position 3 by a methyl group and at position 7 by chlorine. A peripheral vasodilator, it increases the concentration of glucose in the plasma and inhibits the secretion of insulin by the beta- cells of the pancreas. It is used orally in the management of intractable hypoglycaemia and intravenously in the management of hypertensive emergencies. It has a role as an antihypertensive agent, a sodium channel blocker, a vasodilator agent, a K-ATP channel agonist, a beta-adrenergic agonist, a cardiotonic drug, a bronchodilator agent, a sympathomimetic agent and a diuretic. It is a benzothiadiazine, a sulfone and an organochlorine compound. |
| Classification | Small molecule |
| Drug class | — |
| Image (chem structure or protein) | |
| Structure (InChI/SMILES or Protein Sequence) | CC1=Nc2ccc(Cl)cc2S(=O)(=O)N1 |
Target
Agency Approved
No data
Alternate
KCNJ8
KCNJ8
KCNJ11
KCNJ11
NAMPT
NAMPT
Organism
Homo sapiens
Gene name
KCNJ8
Gene synonyms
NCBI Gene ID
Protein name
ATP-sensitive inward rectifier potassium channel 8
Protein synonyms
Inward rectifier K(+) channel Kir6.1, inwardly rectifying potassium channel KIR6.1, Potassium channel, inwardly rectifying subfamily J member 8, potassium voltage-gated channel subfamily J member 8, uKATP-1
Uniprot ID
Mouse ortholog
Kcnj8 (16523)
ATP-sensitive inward rectifier potassium channel 8 (P97794)
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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1,497 adverse events reported
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