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Dextrothyroxine sodium
Choloxin (dextrothyroxine sodium) is a small molecule pharmaceutical. Dextrothyroxine sodium was first approved as Choloxin on 1982-01-01. It is used to treat coronary artery disease, hypercholesterolemia, and hyperlipoproteinemias in the USA. The pharmaceutical is active against thyroid hormone receptor alpha and thyroid hormone receptor beta.
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
cardiovascular diseasesD002318
nutritional and metabolic diseasesD009750
Trade Name
FDA
EMA
No data
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Dextrothyroxine sodium
Tradename
Company
Number
Date
Products
CHOLOXINAbbVieN-012302 DISCN1982-01-01
4 products
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Labels
FDA
EMA
No data
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
coronary artery disease—D003324I25.1
hypercholesterolemiaHP_0003124D006937—
hyperlipoproteinemias—D006951—
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
C: Cardiovascular system drugs
— C10: Lipid modifying agents
— C10A: Lipid modifying agents, plain
— C10AX: Other lipid modifying agents in atc
— C10AX01: Dextrothyroxine
HCPCS
No data
Clinical
Clinical Trials
2 clinical trials
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Indications Phases 4
No data
Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Cardiovascular diseasesD002318EFO_0000319I98——1—12
Myocardial infarctionD009203EFO_0000612I21——1—12
Coronary diseaseD003327——1—12
Myocardial ischemiaD017202EFO_1001375I20-I25——1—12
Heart diseasesD006331EFO_0003777I51.9——1—12
Indications Phases 2
No data
Indications Phases 1
No data
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameDEXTROTHYROXINE SODIUM
INNdextrothyroxine sodium
Description
D-thyroxine is the D-enantiomer of thyroxine. It is a thyroxine and a D-tyrosine derivative. It is an enantiomer of a L-thyroxine.
Classification
Small molecule
Drug class—
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
N[C@H](Cc1cc(I)c(Oc2cc(I)c(O)c(I)c2)c(I)c1)C(=O)[O-].[Na+]
Identifiers
PDB—
CAS-ID51-49-0
RxCUI3292
ChEMBL IDCHEMBL1200777
ChEBI ID—
PubChem CID8730
DrugBankDB00509
UNII IDJ60FX7V025 (ChemIDplus, GSRS)
Target
Agency Approved
THRA
THRA
THRB
THRB
Organism
Homo sapiens
Gene name
THRA
Gene synonyms
EAR7, ERBA1, NR1A1, THRA1, THRA2
NCBI Gene ID
7067
Protein name
thyroid hormone receptor alpha
Protein synonyms
c-erbA protooncogene, c-erbA-1, c-erbA-alpha, EAR-7, ERBA-related 7, Nuclear receptor subfamily 1 group A member 1, thyroid hormone receptor alpha 1, thyroid hormone receptor, alpha (erythroblastic leukemia viral (v-erb-a) oncogene homolog, avian), triiodothyronine receptor, V-erbA-related protein 7
Uniprot ID
P10827
Mouse ortholog
Thra (21833)
thyroid hormone receptor alpha (Q99146)
Alternate
No data
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
Mock data
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Additional graphs summarizing 22 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
0 adverse events reported
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