Dexpramipexole
Dexpramipexole is a small molecule pharmaceutical. It is currently being investigated in clinical studies.
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Abbreviated New Drug Application (ANDA)
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Clinical
Clinical Trials
128 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Parkinson disease | D010300 | EFO_0002508 | G20 | 2 | 6 | 16 | 11 | 14 | 47 |
| Restless legs syndrome | D012148 | EFO_0004270 | G25.81 | — | 4 | 7 | 8 | 3 | 21 |
| Healthy volunteers/patients | — | 10 | — | — | 1 | 1 | 12 | ||
| Depression | D003863 | F33.9 | — | — | 1 | 4 | 2 | 7 | |
| Bipolar disorder | D001714 | EFO_0000289 | F30.9 | — | 3 | — | 2 | — | 5 |
| Major depressive disorder | D003865 | EFO_0003761 | F22 | — | — | 1 | 1 | — | 2 |
| Treatment-resistant depressive disorder | D061218 | — | — | — | 1 | — | 1 | ||
| Adrenoleukodystrophy | D000326 | Orphanet_43 | E71.52 | — | — | — | 1 | — | 1 |
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Amyotrophic lateral sclerosis | D000690 | EFO_0000253 | G12.21 | 6 | 4 | 2 | — | 1 | 11 |
| Tourette syndrome | D005879 | EFO_0004895 | F95.2 | — | 1 | 1 | — | — | 2 |
| Anhedonia | D059445 | R45.84 | — | 1 | 1 | — | — | 2 | |
| Asthma | D001249 | EFO_0000270 | J45 | — | 1 | 1 | — | — | 2 |
| Eosinophilia | D004802 | HP_0001880 | D72.1 | — | 1 | 1 | — | — | 2 |
| Schizophrenia | D012559 | EFO_0000692 | F20 | — | — | 1 | — | — | 1 |
| Psychotic disorders | D011618 | F20.81 | — | — | 1 | — | — | 1 | |
| Essential tremor | D020329 | EFO_0003108 | G25.0 | — | — | 1 | — | — | 1 |
| Opioid-related disorders | D009293 | EFO_0005611 | F11 | — | 1 | 1 | — | — | 1 |
| Sleep wake disorders | D012893 | G47 | — | 1 | 1 | — | — | 1 |
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Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Obsessive-compulsive disorder | D009771 | EFO_0004242 | F42 | 1 | 1 | — | — | — | 2 |
| Parkinsonian disorders | D020734 | HP_0001300 | — | 1 | — | — | — | 1 | |
| Fibromyalgia | D005356 | EFO_0005687 | M79.1 | — | 1 | — | — | — | 1 |
| Renal colic | D056844 | EFO_1001412 | N23 | 1 | 1 | — | — | — | 1 |
| Depressive disorder | D003866 | EFO_1002014 | F32.A | — | 1 | — | — | — | 1 |
| Dysthymic disorder | D019263 | EFO_0008623 | F34.1 | — | 1 | — | — | — | 1 |
| Nasal polyps | D009298 | HP_0100582 | J33 | — | 1 | — | — | — | 1 |
| Hypereosinophilic syndrome | D017681 | EFO_1001467 | D72.11 | — | 1 | — | — | — | 1 |
| Alzheimer disease | D000544 | EFO_0000249 | F03 | — | 1 | — | — | — | 1 |
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Cocaine-related disorders | D019970 | F14 | 1 | — | — | — | — | 1 | |
| Substance-related disorders | D019966 | EFO_0003890 | F13 | 1 | — | — | — | — | 1 |
| Chronic pain | D059350 | HP_0012532 | 1 | — | — | — | — | 1 | |
| Renal insufficiency | D051437 | HP_0000083 | N19 | 1 | — | — | — | — | 1 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Emotions | D004644 | — | — | — | — | 1 | 1 | ||
| Motivation | D009042 | — | — | — | — | 1 | 1 | ||
| Reward | D012201 | — | — | — | — | 1 | 1 | ||
| Heart failure | D006333 | EFO_0003144 | I50 | — | — | — | — | 1 | 1 |
| Anxiety | D001007 | EFO_0005230 | F41.1 | — | — | — | — | 1 | 1 |
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | DEXPRAMIPEXOLE |
| INN | dexpramipexole |
| Description | Dexpramipexole (KNS-760704) is an orally administered drug candidate shown to selectively and significantly lower eosinophil counts in human blood and tissue. The drug is currently in clinical development for eosinophil-associated diseases by Knopp Biosciences LLC.
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| Classification | Small molecule |
| Drug class | — |
| Image (chem structure or protein) | |
| Structure (InChI/SMILES or Protein Sequence) | CCCN[C@@H]1CCc2nc(N)sc2C1 |
Identifiers
| PDB | — |
| CAS-ID | 104632-28-2 |
| RxCUI | — |
| ChEMBL ID | CHEMBL249420 |
| ChEBI ID | — |
| PubChem CID | 59868 |
| DrugBank | DB15130 |
| UNII ID | WI638GUS96 (ChemIDplus, GSRS) |
Target
Agency Approved
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Variants
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Safety
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