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Dexbrompheniramine
Brompheril, Disobrom, Disomer, Disophrol, Drixoral, Resporal (dexbrompheniramine) is a small molecule pharmaceutical. Dexbrompheniramine was first approved as Disomer on 1982-01-01. It is used to treat allergic rhinitis perennial, common cold, sinusitis, and urticaria in the USA.
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
infectionsD007239
respiratory tract diseasesD012140
otorhinolaryngologic diseasesD010038
skin and connective tissue diseasesD017437
immune system diseasesD007154
Trade Name
FDA
EMA
No data
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Acetaminophen
+
Dexbrompheniramine maleate
+
Pseudoephedrine sulfate
Tradename
Company
Number
Date
Products
DRIXORAL PLUSMerck Sharp & DohmeN-019453 DISCN1987-05-22
1 products
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Dexbrompheniramine maleate
Tradename
Company
Number
Date
Products
DISOMERMerck Sharp & DohmeN-011814 DISCN1982-01-01
2 products
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Dexbrompheniramine maleate
+
Pseudoephedrine sulfate
Tradename
Company
Number
Date
Products
DISOPHROLMerck Sharp & DohmeN-012394 DISCN1982-01-01
1 products
DRIXORALMerck Sharp & DohmeN-013483 DISCN1982-09-13
1 products, RLD
DISOPHROLMerck Sharp & DohmeN-013483 DISCN1982-09-13
1 products
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Labels
FDA
EMA
Brand Name
Status
Last Update
ala-hist irOTC monograph final2023-02-15
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
allergic rhinitis perennialEFO_1001417D012221J30.89
common coldEFO_0007214D003139J00
sinusitisEFO_0007486D012852J32
urticariaEFO_0005531D014581L50
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
R: Respiratory system drugs
— R06: Antihistamines for systemic use
— R06A: Antihistamines for systemic use
— R06AB: Substituted alkylamines, systemic antihistamines
— R06AB06: Dexbrompheniramine
— R06AB56: Dexbrompheniramine, combinations
HCPCS
No data
Clinical
Indications Phases 4
No data
Indications Phases 3
No data
Indications Phases 2
No data
Indications Phases 1
No data
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameDEXBROMPHENIRAMINE
INNdexbrompheniramine
Description
Dexbrompheniramine is the (pharmacologically active) (S)-(+)-enantiomer of brompheniramine. A histamine H1 receptor antagonist, it is used (commonly as its maleate salt) for the symptomatic relief of allergic conditions, including rhinitis and conjunctivitis. It has a role as a H1-receptor antagonist and an anti-allergic agent.
Classification
Small molecule
Drug class—
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
CN(C)CC[C@@H](c1ccc(Br)cc1)c1ccccn1
Identifiers
PDB—
CAS-ID132-21-8
RxCUI22696
ChEMBL IDCHEMBL1201287
ChEBI ID59269
PubChem CID16960
DrugBankDB00405
UNII ID75T64B71RP (ChemIDplus, GSRS)
Target
Agency Approved
No data
Alternate
No data
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
Mock data
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Additional graphs summarizing 80 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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1 adverse events reported
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