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Desoxycorticosterone
Doca, Percorten (desoxycorticosterone) is a small molecule pharmaceutical. Desoxycorticosterone was first approved as Percorten on 1982-01-01. It is known to target mineralocorticoid receptor, glucocorticoid receptor, and nuclear receptor subfamily 0 group B member 2.
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Commercial
Therapeutic Areas
No data
Trade Name
FDA
EMA
No data
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Desoxycorticosterone acetate
Tradename
Company
Number
Date
Products
PERCORTENNovartisN-005151 DISCN1982-01-01
1 products
DOCAOrganonN-001104 DISCN1982-01-01
1 products
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Desoxycorticosterone pivalate
Tradename
Company
Number
Date
Products
PERCORTENNovartisN-008822 DISCN1982-01-01
1 products
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Labels
FDA
EMA
No data
Indications
FDA
EMA
No data
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
H: Systemic hormonal preparations, excl. sex hormones and insulins
— H02: Corticosteroids for systemic use
— H02A: Corticosteroids for systemic use, plain
— H02AA: Mineralocorticoids for systemic use, plain
— H02AA03: Desoxycortone
HCPCS
No data
Clinical
Clinical Trials
42 clinical trials
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Indications Phases 4
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
ContraceptionD003267——2169
InfertilityD007246EFO_0000545——1315
Premenstrual syndromeD011293N94.3———1—1
Acne vulgarisD000152EFO_0003894L70———1—1
Chinese traditional medicineD008516———1—1
HemorrhageD006470MP_0001914R58———1—1
LeiomyomaD007889HP_0000131D25———1—1
Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Healthy volunteers/patients——11——2
EndometriosisD004715EFO_0001065N80—11—12
Polycystic ovary syndromeD011085EFO_0000660E28.2——1——1
Female infertilityD007247EFO_0008560N97——1——1
MetrorrhagiaD008796HP_0100608N92.1——1——1
Central sleep apneaD020182G47.31—11——1
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
HemostasisD006487—2———2
Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Biological availabilityD0016821————1
Therapeutic equivalencyD0138101————1
Indications Without Phase
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Contraception behaviorD003268————11
Fertilization in vitroD005307————11
Drug-related side effects and adverse reactionsD064420T88.7————11
CardiomyopathiesD009202EFO_0000318I42————11
BradycardiaD001919HP_0001662R00.1————11
Atrioventricular blockD054537I44.3————11
Bundle-branch blockD002037EFO_0004138I44.7————11
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameDESOXYCORTICOSTERONE
INNdesoxycortone
Description
11-deoxycorticosterone is a mineralocorticoid that is progesterone substituted at position 21 by a hydroxy group. It has a role as a human metabolite and a mouse metabolite. It is a mineralocorticoid, a 3-oxo-Delta(4) steroid, a 20-oxo steroid, a 21-hydroxy steroid and a primary alpha-hydroxy ketone. It is functionally related to a progesterone.
Classification
Small molecule
Drug class—
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
C[C@]12CC[C@H]3[C@@H](CCC4=CC(=O)CC[C@@]43C)[C@@H]1CC[C@@H]2C(=O)CO
Identifiers
PDB2Q3Y
CAS-ID64-85-7
RxCUI3256
ChEMBL IDCHEMBL1498
ChEBI ID16973
PubChem CID6166
DrugBankDB15972
UNII ID40GP35YQ49 (ChemIDplus, GSRS)
Target
Agency Approved
No data
Alternate
NR3C2
NR3C2
NR3C1
NR3C1
NR0B2
NR0B2
Organism
Homo sapiens
Gene name
NR3C2
Gene synonyms
MCR, MLR
NCBI Gene ID
4306
Protein name
mineralocorticoid receptor
Protein synonyms
aldosterone receptor, mineralocorticoid receptor 1, mineralocorticoid receptor 2, mineralocorticoid receptor delta, Nuclear receptor subfamily 3 group C member 2
Uniprot ID
Q96KQ9
Mouse ortholog
Nr3c2 (110784)
mineralocorticoid receptor (Q8VII8)
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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2,710 adverse events reported
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