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Desoximetasone
Topicort (desoximetasone) is a small molecule pharmaceutical. Desoximetasone was first approved as Topicort on 1982-01-01. It is used to treat facial dermatoses, foot dermatoses, hand dermatoses, inflammation, and leg dermatoses amongst others in the USA. The pharmaceutical is active against glucocorticoid receptor.
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
skin and connective tissue diseasesD017437
signs and symptoms pathological conditionsD013568
Trade Name
FDA
EMA
Topicort (generic drugs available since 1990-11-30)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Desoximetasone
Tradename
Company
Number
Date
Products
TOPICORTTaro PharmaceuticalN-018594 RX1985-01-17
1 products, RLD, RS
TOPICORTTaro PharmaceuticalN-204141 RX2013-04-11
1 products, RLD, RS
Show 4 discontinued
Labels
FDA
EMA
Brand Name
Status
Last Update
desoximetasoneANDA2023-06-07
topicortNew Drug Application2021-09-14
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
facial dermatoses—D005148—
foot dermatoses—D005533—
hand dermatoses—D006229—
inflammationMP_0001845D007249—
leg dermatoses—D007868—
scalp dermatoses—D012536—
Agency Specific
FDA
EMA
No data
Patent Expiration
Patent
Expires
Flag
FDA Information
Desoximetasone, Topicort, Taro Pharms
82777802028-09-01DPU-1408
87156242026-05-26DPU-1408
ATC Codes
D: Dermatologicals
— D07: Corticosteroids, dermatological preparations
— D07A: Corticosteroid dermatological preparations, plain
— D07AC: Corticosteroids, potent (group iii)
— D07AC03: Desoximetasone
— D07X: Corticosteroids, other combinations
— D07XC: Corticosteroids, potent, other combinations
— D07XC02: Desoximetasone
HCPCS
No data
Clinical
Clinical Trials
11 clinical trials
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Indications Phases 4
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Atopic dermatitisD003876EFO_0000274L20——33—6
EczemaD004485HP_0000964L30.9——11—2
PsoriasisD011565EFO_0000676L40———1—1
HyperpigmentationD017495———1—1
Indications Phases 3
No data
Indications Phases 2
No data
Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Healthy volunteers/patients—1————1
VasoconstrictionD0146611————1
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameDESOXIMETASONE
INNdesoximetasone
Description
Desoximetasone is dexamethasone in which the hydroxy group at the 17alpha position is substituted by hydrogen. A synthetic corticosteroid with glucocorticoid activity, it is used as an anti-inflammatory and anti-pruritic in the treatment of various skin disorders, including skin allergies and psoriasis. It has a role as an anti-inflammatory drug and an antipruritic drug. It is an 11beta-hydroxy steroid, a 21-hydroxy steroid, a glucocorticoid, a 20-oxo steroid, a fluorinated steroid, a 3-oxo-Delta(1),Delta(4)-steroid and a primary alpha-hydroxy ketone.
Classification
Small molecule
Drug class—
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
C[C@@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@]2(C)[C@H]1C(=O)CO
Identifiers
PDB—
CAS-ID382-67-2
RxCUI3255
ChEMBL IDCHEMBL1766
ChEBI ID691037
PubChem CID5311067
DrugBankDB00547
UNII ID4E07GXB7AU (ChemIDplus, GSRS)
Target
Agency Approved
NR3C1
NR3C1
Organism
Homo sapiens
Gene name
NR3C1
Gene synonyms
GRL
NCBI Gene ID
2908
Protein name
glucocorticoid receptor
Protein synonyms
Nuclear receptor subfamily 3 group C member 1, nuclear receptor subfamily 3 group C member 1 variant hGR-B(54), nuclear receptor subfamily 3 group C member 1 variant hGR-B(77), nuclear receptor subfamily 3 group C member 1 variant hGR-B(93), nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
Uniprot ID
Q6N0A4
Mouse ortholog
Nr3c1 (14815)
glucocorticoid receptor (Q61629)
Alternate
No data
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
Mock data
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Additional graphs summarizing 207 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
Mock data
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36,824 adverse events reported
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