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Desogestrel
Cyclessa (desogestrel) is a small molecule pharmaceutical. Desogestrel was first approved as Desogen on 1992-12-10. It is used to treat acne vulgaris, endometriosis, and menstruation disturbances in the USA.
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
urogenital diseasesD000091642
skin and connective tissue diseasesD017437
signs and symptoms pathological conditionsD013568
Trade Name
FDA
EMA
Combinations
Cyclessa (generic drugs available since 1999-08-12, discontinued: Desogen, Emoquette, Mircette, Ortho-cept)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Desogestrel
+
Ethinyl estradiol
Tradename
Company
Number
Date
Products
CYCLESSAAspen GlobalN-021090 RX2000-12-20
1 products, RLD, RS
Show 3 discontinued
Labels
FDA
EMA
Brand Name
Status
Last Update
bekyree ANDA2021-12-18
emoquetteANDA2021-01-20
enskyce ANDA2020-02-04
isibloomANDA2023-03-15
kalligaANDA2021-02-01
karivaANDA2017-04-30
mircetteANDA2017-04-30
pimtrea ANDA2018-11-26
reclipsenANDA2023-06-07
simliyaANDA2021-02-06
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Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
acne vulgarisEFO_0003894D000152L70
endometriosisEFO_0001065D004715N80
menstruation disturbancesHP_0400007D008599N91.5
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
G: Genito urinary system and sex hormones
G03: Sex hormones and modulators of the genital system
G03A: Hormonal contraceptives for systemic use
G03AA: Progestogens and estrogen systemic contraceptives, fixed combinations
G03AA09: Desogestrel and ethinylestradiol
G03AB: Progestogens and estrogens systemic contraceptives, sequential preparations
G03AB05: Desogestrel and ethinylestradiol
G03AC: Progestogen systemic hormonal contraceptives
G03AC09: Desogestrel
G03F: Progestogens and estrogens in combination
G03FB: Progestogens and estrogens, sequential preparations
G03FB10: Desogestrel and estrogen
HCPCS
No data
Clinical
Clinical Trials
87 clinical trials
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Indications Phases 4
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
NocturiaD053158R35.17162427
Nocturnal enuresisD053206N39.4437414
Hemophilia aD006467EFO_0007267D661225
HemorrhageD006470MP_0001914R581124
HypothermiaD007035HP_0002045T68112
Blood coagulation disordersD001778EFO_0009314D68.9112
Sickle cell anemiaD000755EFO_0000697D57112
Postoperative hemorrhageD01910622
Cardiac surgical proceduresD00634811
Aortic valve stenosisD001024EFO_0000266Q25.111
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Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Renal colicD056844EFO_1001412N23112
Neurogenic diabetes insipidusD020790HP_0000863112
LeptospirosisD007922EFO_0007344A27111
PainD010146EFO_0003843R5211
Obstructive sleep apneaD020181EFO_0003918G47.3311
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
StrokeD020521EFO_0000712I63.9112
Cerebral hemorrhageD00254311
EcchymosisD004438HP_000097811
Overactive urinary bladderD053201EFO_1000781N32.8111
Colorectal neoplasmsD01517911
Breast neoplasmsD001943EFO_0003869C5011
Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
HypertensionD006973EFO_0000537I1011
DyspneaD004417HP_0002094R06.011
TachycardiaD013610HP_0001649R00.011
Prostatic neoplasmsD011471C6111
AtherosclerosisD050197EFO_0003914I25.111
Intracranial arteriosclerosisD002537EFO_1000860I67.211
Healthy volunteers/patients11
Indications Without Phase
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Diabetes insipidusD003919E23.222
Wounds and injuriesD014947T14.811
HemodilutionD00643811
MenorrhagiaD008595N92.011
Hematologic diseasesD006402EFO_0005803D75.911
Blood platelet disordersD00179111
Von willebrand diseasesD014842D68.011
Drug-related side effects and adverse reactionsD064420T88.711
Liver cirrhosisD008103EFO_0001422K74.011
Nephrogenic diabetes insipidusD018500N25.111
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameDESOGESTREL
INNdesogestrel
Description
Desogestrel is a 17beta-hydroxy steroid and a terminal acetylenic compound. It has a role as a contraceptive drug, a progestin and a synthetic oral contraceptive.
Classification
Small molecule
Drug classestrogens; progestins
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
C#C[C@]1(O)CC[C@H]2[C@@H]3CCC4=CCCC[C@@H]4[C@H]3C(=C)C[C@@]21CC
Identifiers
PDB
CAS-ID54024-22-5
RxCUI22656
ChEMBL IDCHEMBL1533
ChEBI ID4453
PubChem CID40973
DrugBankDB00304
UNII ID81K9V7M3A3 (ChemIDplus, GSRS)
Target
Agency Approved
No data
Alternate
No data
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 1,556 documents
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Safety
Black-box Warning
Black-box warning for: Emoquette, Enskyce , Isibloom, Kalliga, Volnea
Adverse Events
Top Adverse Reactions
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8,845 adverse events reported
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