Dequalinium chloride
Dequalinium chloride is a small molecule pharmaceutical. It is currently being investigated in clinical studies. It is known to target cGMP-gated cation channel alpha-1, cyclic nucleotide-gated olfactory channel, small conductance calcium-activated potassium channel protein 1, small conductance calcium-activated potassium channel protein 3, and small conductance calcium-activated potassium channel protein 2.
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Commercial
Therapeutic Areas
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Trade Name
FDA
EMA
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Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
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Labels
FDA
EMA
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Indications
FDA
EMA
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Agency Specific
FDA
EMA
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Patent Expiration
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ATC Codes
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HCPCS
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Clinical
Clinical Trials
3 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Vulvovaginal candidiasis | D002181 | EFO_0007543 | B37.3 | — | — | — | 1 | — | 1 |
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Bacterial vaginosis | D016585 | EFO_0003932 | — | — | 1 | — | — | 1 |
Indications Phases 2
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Indications Phases 1
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Indications Without Phase
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | DEQUALINIUM CHLORIDE |
| INN | dequalinium chloride |
| Description | Dequalinium chloride is an organic chloride salt that is the dichloride salt of dequalinium. It has a role as an antiseptic drug, a mitochondrial NADH:ubiquinone reductase inhibitor, an antifungal agent and an antineoplastic agent. It contains a dequalinium. |
| Classification | Small molecule |
| Drug class | quaternary ammonium derivatives |
| Image (chem structure or protein) | |
| Structure (InChI/SMILES or Protein Sequence) | Cc1cc(N)c2ccccc2[n+]1CCCCCCCCCC[n+]1c(C)cc(N)c2ccccc21.[Cl-].[Cl-] |
Identifiers
| PDB | — |
| CAS-ID | 522-51-0 |
| RxCUI | 3120 |
| ChEMBL ID | CHEMBL121663 |
| ChEBI ID | 31466 |
| PubChem CID | 10649 |
| DrugBank | DBSALT001926 |
| UNII ID | XYS8INN1I6 (ChemIDplus, GSRS) |
Target
Agency Approved
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Alternate
CNGA1
CNGA1
CNGA2
CNGA2
KCNN1
KCNN1
KCNN3
KCNN3
KCNN2
KCNN2
Organism
Homo sapiens
Gene name
CNGA1
Gene synonyms
CNCG, CNCG1
NCBI Gene ID
Protein name
cGMP-gated cation channel alpha-1
Protein synonyms
CNG channel alpha-1, CNG-1, CNG1, cyclic nucleotide gated channel alpha 1, Cyclic nucleotide-gated cation channel 1, Cyclic nucleotide-gated channel alpha-1, Cyclic nucleotide-gated channel, photoreceptor, interleukin-1 homologue, Rod photoreceptor cGMP-gated channel subunit alpha
Uniprot ID
Mouse ortholog
Cnga1 (12788)
cGMP-gated cation channel alpha-1 (Q60776)
Variants
Clinical Variant
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Financial
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Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 256 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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45 adverse events reported
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