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Deoxycholic acid
Kybella (deoxycholic acid) is a small molecule pharmaceutical. Deoxycholic acid was first approved as Kybella on 2015-04-29. It is known to target fMet-Leu-Phe receptor, bile acid receptor, and G-protein coupled bile acid receptor 1.
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Commercial
Therapeutic Areas
No data
Trade Name
FDA
EMA
Kybella (generic drugs available since 2021-04-02)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Deoxycholic acid
Tradename
Company
Number
Date
Products
KYBELLAKythera BiopharmaceuticalsN-206333 RX2015-04-29
1 products, RLD, RS
Labels
FDA
EMA
Brand Name
Status
Last Update
kybellaNew Drug Application2020-05-01
Indications
FDA
EMA
No data
Agency Specific
FDA
EMA
No data
Patent Expiration
Patent
Expires
Flag
FDA Information
Deoxycholic Acid, Kybella, Kythera Biopharms
81015932030-03-02DP
83676492030-03-02DP
86530582030-03-02DP
105002142030-03-02DP
82422942028-05-16DP
84611402028-02-21DP
85463672028-02-21DPU-1690
88837702028-02-21DP
95221552028-02-21DPU-1940
96363492028-02-21U-1940
99499862028-02-21U-1940
76221302027-12-10U-1690
77542302027-12-10U-1690
82985562025-08-03U-1690
88460662025-02-08U-1690
ATC Codes
D: Dermatologicals
— D11: Other dermatological preparations in atc
— D11A: Other dermatological preparations in atc
— D11AX: Other dermatological preparations in atc
— D11AX24: Deoxycholic acid
HCPCS
Code
Description
J0591
Injection, deoxycholic acid, 1 mg
Clinical
Clinical Trials
45 clinical trials
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Indications Phases 4
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
T-cell lymphoma cutaneousD016410C84.A—113—5
Sezary syndromeD012751C84.1———2—2
Mycosis fungoidesD009182C84.0———2—2
Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
T-cell lymphoma peripheralD016411C84.9141——6
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
LymphomaD008223C85.9—5——16
MelanomaD00854526———6
Ovarian epithelial carcinomaD00007721633———5
Fallopian tube neoplasmsD00518512———3
LeukemiaD007938C95—3———3
Breast neoplasmsD001943EFO_0003869C5031———3
Kidney neoplasmsD007680EFO_0003865C6411———2
B-cell chronic lymphocytic leukemiaD015451C91.111———2
Pancreatic neoplasmsD010190EFO_0003860C2511———2
B-cell lymphomaD016393—2———2
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Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
NeoplasmsD009369C801———12
Endometrioid carcinomaD0182691————1
CystadenocarcinomaD0035361————1
Non-small-cell lung carcinomaD0022891————1
Multiple myelomaD009101C90.01————1
Colorectal neoplasmsD0151791————1
Lung neoplasmsD008175C34.901————1
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameDEOXYCHOLIC ACID
INNdeoxycholic acid
Description
Deoxycholic acid is a bile acid that is 5beta-cholan-24-oic acid substituted by hydroxy groups at positions 3 and 12 respectively. It has a role as a human blood serum metabolite. It is a bile acid, a dihydroxy-5beta-cholanic acid and a C24-steroid. It is a conjugate acid of a deoxycholate.
Classification
Small molecule
Drug class—
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
C[C@H](CCC(=O)O)[C@H]1CC[C@H]2[C@@H]3CC[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3C[C@H](O)[C@@]21C
Identifiers
PDB—
CAS-ID83-44-3
RxCUI—
ChEMBL IDCHEMBL406393
ChEBI ID28834
PubChem CID222528
DrugBankDB03619
UNII ID005990WHZZ (ChemIDplus, GSRS)
Target
Agency Approved
No data
Alternate
FPR1
FPR1
NR1H4
NR1H4
GPBAR1
GPBAR1
Organism
Homo sapiens
Gene name
FPR1
Gene synonyms
NCBI Gene ID
2357
Protein name
fMet-Leu-Phe receptor
Protein synonyms
fMLP receptor, FPR, N-formyl peptide receptor, N-formylpeptide chemoattractant receptor
Uniprot ID
Q9NS48
Mouse ortholog
Fpr1 (14293)
fMet-Leu-Phe receptor (Q3UV01)
Variants
Clinical Variant
No data
Financial
Kybella - Allergan
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Kybella - Kythera Biopharmaceuticals
$
€
£
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Kybella - Warner Chilcott
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Tabular view
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 15,726 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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277 adverse events reported
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