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Demcizumab
Hemlibra (demcizumab) is an antibody pharmaceutical. Demcizumab was first approved as Hemlibra on 2018-02-23. It has been approved in Europe to treat hemophilia a. The pharmaceutical is active against delta-like protein 4.
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
hemic and lymphatic diseasesD006425
hereditary congenital and neonatal diseases and abnormalitiesD009358
Trade Name
FDA
EMA
No data
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
No data
Labels
FDA
EMA
Brand Name
Status
Last Update
hemlibraBiologic Licensing Application2022-12-05
Indications
FDA
EMA
No data
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
No data
HCPCS
No data
Clinical
Clinical Trials
11 clinical trials
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Indications Phases 4
No data
Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Hemophilia aD006467EFO_0007267D66——2—13
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Non-small-cell lung carcinomaD00228911———2
Pancreatic neoplasmsD010190EFO_0003860C2511———2
Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
NeoplasmsD009369C802————2
Colorectal neoplasmsD0151791————1
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameDEMCIZUMAB
INNdemcizumab
Description
Demcizumab (humanized mab)
Classification
Antibody
Drug classmonoclonal antibodies
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)—
Identifiers
PDB—
CAS-ID1243262-17-0
RxCUI—
ChEMBL IDCHEMBL2109384
ChEBI ID—
PubChem CID—
DrugBankDB12734
UNII IDSF168W7FW0 (ChemIDplus, GSRS)
Target
Agency Approved
DLL4
DLL4
Organism
Homo sapiens
Gene name
DLL4
Gene synonyms
NCBI Gene ID
54567
Protein name
delta-like protein 4
Protein synonyms
delta 4, delta ligand 4, delta-like 4 homolog, delta-like 4 protein, Delta4, Drosophila Delta homolog 4, notch ligand delta-2, notch ligand DLL4
Uniprot ID
Q9NR61
Mouse ortholog
Dll4 (54485)
delta-like protein 4 (Q9JI71)
Alternate
No data
Variants
Clinical Variant
No data
Financial
Hemlibra - Roche
$
€
£
₣
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Tabular view
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 396 documents
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Safety
Black-box Warning
Black-box warning for: Hemlibra
Adverse Events
Top Adverse Reactions
0 adverse events reported
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