Darexaban
Darexaban is a small molecule pharmaceutical. It is currently being investigated in clinical studies.
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Therapeutic Areas
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Trade Name
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Drug Products
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EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
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Labels
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Indications
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Agency Specific
FDA
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Patent Expiration
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ATC Codes
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HCPCS
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Clinical
Clinical Trials
25 clinical trials
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Indications Phases 4
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Venous thromboembolism | D054556 | EFO_0004286 | I74 | — | 3 | 7 | — | — | 7 |
| Replacement arthroplasty hip | D019644 | — | 1 | 1 | — | — | 1 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Thromboembolism | D013923 | HP_0001907 | — | 2 | — | — | — | 2 | |
| Atrial fibrillation | D001281 | EFO_0000275 | I48.0 | — | 2 | — | — | — | 2 |
| Acute coronary syndrome | D054058 | EFO_0005672 | — | 1 | — | — | — | 1 | |
| Replacement arthroplasty knee | D019645 | — | 1 | — | — | — | 1 |
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Healthy volunteers/patients | — | 11 | — | — | — | — | 11 | ||
| Pharmacokinetics | D010599 | 2 | — | — | — | — | 2 |
Indications Without Phase
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | DAREXABAN |
| INN | darexaban |
| Description | Darexaban (YM150) is a direct inhibitor of factor Xa created by Astellas Pharma. It is an experimental drug that acts as an anticoagulant and antithrombotic to prevent venous thromboembolism after a major orthopaedic surgery, stroke in patients with atrial fibrillation and possibly ischemic events in acute coronary syndrome. It is used in form of the maleate. The development of darexaban was discontinued in September 2011.
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| Classification | Small molecule |
| Drug class | antithrombotics, blood coagulation factor XA inhibitors |
| Image (chem structure or protein) | |
| Structure (InChI/SMILES or Protein Sequence) | COc1ccc(C(=O)Nc2cccc(O)c2NC(=O)c2ccc(N3CCCN(C)CC3)cc2)cc1 |
Identifiers
| PDB | — |
| CAS-ID | 365462-23-3 |
| RxCUI | — |
| ChEMBL ID | CHEMBL1922235 |
| ChEBI ID | — |
| PubChem CID | 9912771 |
| DrugBank | DB12289 |
| UNII ID | KF322K101S (ChemIDplus, GSRS) |
Target
Agency Approved
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Alternate
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Variants
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Financial
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Trends
PubMed Central
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Safety
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Adverse Events
Top Adverse Reactions
0 adverse events reported
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