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Danavorexton
Danavorexton is a small molecule pharmaceutical. It is currently being investigated in clinical studies. It is known to target orexin receptor type 2.
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Commercial
Therapeutic Areas
No data
Trade Name
FDA
EMA
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Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
No data
Labels
FDA
EMA
No data
Indications
FDA
EMA
No data
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
No data
HCPCS
No data
Clinical
Clinical Trials
7 clinical trials
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Indications Phases 4
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Indications Phases 3
No data
Indications Phases 2
No data
Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Healthy volunteers/patients—3————3
NarcolepsyD009290EFO_0000614G47.42————2
Idiopathic hypersomniaD020177G47.111————1
Obstructive sleep apneaD020181EFO_0003918G47.331————1
Sleep apnea syndromesD012891EFO_0003877G47.31————1
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameDANAVOREXTON
INNdanavorexton
Description
Danavorexton (developmental code name TAK-925) is a selective orexin 2 receptor agonist. It is a small-molecule compound and is administered intravenously. The compound was found to dose-dependently produce wakefulness to a similar degree as modafinil in a phase 1 clinical trial. As of March 2021, danavorexton is under development for the treatment of narcolepsy, idiopathic hypersomnia, and sleep apnea. It is related to another orexin receptor agonist known as TAK-994, the development of which was discontinued for safety reasons in October 2021.
Classification
Small molecule
Drug classOrexin receptor agonist
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
COC(=O)N1CCC[C@H](NS(C)(=O)=O)[C@@H]1CO[C@H]1CC[C@@H](c2ccccc2)CC1
Identifiers
PDB—
CAS-ID2114324-48-8
RxCUI—
ChEMBL IDCHEMBL4650341
ChEBI ID—
PubChem CID130310079
DrugBank—
UNII ID1QMD83K4YN (ChemIDplus, GSRS)
Target
Agency Approved
No data
Alternate
HCRTR2
HCRTR2
Organism
Homo sapiens
Gene name
HCRTR2
Gene synonyms
NCBI Gene ID
3062
Protein name
orexin receptor type 2
Protein synonyms
hypocretin (orexin) receptor 2, Hypocretin receptor type 2, orexin type-2 receptor
Uniprot ID
Q5VTM0
Mouse ortholog
Hcrtr2 (387285)
orexin receptor type 2 (Q8BG12)
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 4 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
0 adverse events reported
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