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Cyproterone acetate
Cyproterone acetate is a small molecule pharmaceutical. It is currently being investigated in clinical studies. The pharmaceutical is active against androgen receptor.
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Commercial
Therapeutic Areas
No data
Trade Name
FDA
EMA
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Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
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Labels
FDA
EMA
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Indications
FDA
EMA
No data
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
G: Genito urinary system and sex hormones
G03: Sex hormones and modulators of the genital system
G03H: Antiandrogen sex hormones and modulators of the genital system
G03HA: Antiandrogens, plain
G03HA01: Cyproterone
G03HB: Antiandrogens and estrogens
G03HB01: Cyproterone and estrogen
HCPCS
No data
Clinical
Clinical Trials
39 clinical trials
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Mock data
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Indications Phases 4
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Polycystic ovary syndromeD011085EFO_0000660E28.2114511
Acne vulgarisD000152EFO_0003894L701124
HyperandrogenismD017588213
Menstruation disturbancesD008599HP_0400007N91.522
Gender dysphoriaD000068116F6411
AmenorrheaD000568N91.211
DysmenorrheaD004412HP_0100607N94.611
TranssexualismD014189F64.011
Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Prostatic neoplasmsD011471C611438
EndometriosisD004715EFO_0001065N8011
Diabetic nephropathiesD003928EFO_000040111
AdenocarcinomaD00023011
PedophiliaD010378F65.411
Hot flashesD01958411
Endometrial neoplasmsD016889EFO_0004230111
Endometrial hyperplasiaD004714N85.0111
Indications Phases 2
No data
Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Prostatic hyperplasiaD011470EFO_0000284N4011
Indications Without Phase
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Drug interactionsD00434711
Insulin resistanceD007333EFO_000261411
Metabolic syndromeD024821EFO_0000195E88.8111
Professional burnoutD00205511
Seborrheic dermatitisD012628L2111
PeriodontitisD010518EFO_0000649K05.311
GingivitisD005891K05.1011
Periodontal diseasesD010510K05.611
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameCYPROTERONE ACETATE
INNcyproterone
Description
Cyproterone acetate is a steroid ester resulting from the formal condensation of the carboxy group of acetic acid with the 17-hydroxy group of cyproterone. It is an antiandrogenic drug which has recently been recognized to promote the occurrence and growth of intracranial meningiomas. It has a role as an androgen antagonist, a progestin and a geroprotector. It is a 20-oxo steroid, a 3-oxo-Delta(4) steroid, a chlorinated steroid, a steroid ester and an acetate ester. It is functionally related to a cyproterone.
Classification
Small molecule
Drug classantiandrogens
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
CC(=O)O[C@]1(C(C)=O)CC[C@H]2[C@@H]3C=C(Cl)C4=CC(=O)[C@@H]5C[C@@H]5[C@]4(C)[C@H]3CC[C@@]21C
Identifiers
PDB
CAS-ID427-51-0
RxCUI
ChEMBL IDCHEMBL139835
ChEBI ID50743
PubChem CID9880
DrugBankDB04839
UNII IDE61Q31EK2F (ChemIDplus, GSRS)
Target
Agency Approved
AR
AR
Organism
Homo sapiens
Gene name
AR
Gene synonyms
DHTR, NR3C4
NCBI Gene ID
Protein name
androgen receptor
Protein synonyms
Dihydrotestosterone receptor, Nuclear receptor subfamily 3 group C member 4
Uniprot ID
Mouse ortholog
Ar (11835)
androgen receptor (P19091)
Alternate
No data
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 3,179 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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891 adverse events reported
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