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Cyproheptadine
Periactin (cyproheptadine) is a small molecule pharmaceutical. Cyproheptadine was first approved as Periactin on 1982-01-01. It is used to treat allergic rhinitis perennial, blepharospasm, cluster headache, dyskinesias, and nelson syndrome amongst others in the USA. The pharmaceutical is active against histamine H1 receptor. In addition, it is known to target alpha-1A adrenergic receptor, alpha-1D adrenergic receptor, alpha-1B adrenergic receptor, 5-hydroxytryptamine receptor 7, 5-hydroxytryptamine receptor 6, and histone-lysine N-methyltransferase SETD7.
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Therapeutic Areas
Therapeutic Area
MeSH
neoplasmsD009369
respiratory tract diseasesD012140
otorhinolaryngologic diseasesD010038
nervous system diseasesD009422
eye diseasesD005128
skin and connective tissue diseasesD017437
endocrine system diseasesD004700
immune system diseasesD007154
signs and symptoms pathological conditionsD013568
mental disordersD001523
Trade Name
FDA
EMA
No data
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Cyproheptadine hydrochloride
Tradename
Company
Number
Date
Products
PERIACTINMerck KGaAN-012649 DISCN1982-01-01
1 products, RLD
PERIACTINMerck KGaAN-013220 DISCN1982-01-01
1 products, RLD
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Labels
FDA
EMA
Brand Name
Status
Last Update
cyproheptadine hydrochlorideANDA2023-03-29
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
allergic rhinitis perennialEFO_1001417D012221J30.89
blepharospasmD001764G24.5
cluster headacheHP_0012199D003027G44.00
dyskinesiasD020820G24
nelson syndromeD009347E24.1
pruritusHP_0000989D011537L29
schizophreniaEFO_0000692D012559F20
spastic paraparesisHP_0002313D020336
urticariaEFO_0005531D014581L50
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
R: Respiratory system drugs
R06: Antihistamines for systemic use
R06A: Antihistamines for systemic use
R06AX: Other antihistamines for systemic use in atc
R06AX02: Cyproheptadine
HCPCS
No data
Clinical
Indications Phases 4
No data
Indications Phases 3
No data
Indications Phases 2
No data
Indications Phases 1
No data
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameCYPROHEPTADINE
INNcyproheptadine
Description
Cyproheptadine is the product resulting from the formal oxidative coupling of position 5 of 5H-dibenzo[a,d]cycloheptene with position 4 of 1-methylpiperidine resulting in the formation of a double bond between the two fragments. It is a sedating antihistamine with antimuscarinic and calcium-channel blocking actions. It is used (particularly as the hydrochloride sesquihydrate) for the relief of allergic conditions including rhinitis, conjunctivitis due to inhalant allergens and foods, urticaria and angioedema, and in pruritic skin disorders. Unlike other antihistamines, it is also a seratonin receptor antagonist, making it useful in conditions such as vascular headache and anorexia. It has a role as a H1-receptor antagonist, a serotonergic antagonist, an antipruritic drug, an anti-allergic agent and a gastrointestinal drug. It is a member of piperidines and a tertiary amine.
Classification
Small molecule
Drug class
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
CN1CCC(=C2c3ccccc3C=Cc3ccccc32)CC1
Identifiers
PDB5AYF
CAS-ID129-03-3
RxCUI3013
ChEMBL IDCHEMBL516
ChEBI ID4046
PubChem CID2913
DrugBankDB00434
UNII ID2YHB6175DO (ChemIDplus, GSRS)
Target
Agency Approved
HRH1
HRH1
Organism
Homo sapiens
Gene name
HRH1
Gene synonyms
NCBI Gene ID
Protein name
histamine H1 receptor
Protein synonyms
histamine receptor, subclass H1
Uniprot ID
Mouse ortholog
Hrh1 (15465)
histamine H1 receptor (Q91XN3)
Alternate
ADRA1A
ADRA1A
ADRA1D
ADRA1D
ADRA1B
ADRA1B
HTR7
HTR7
HTR6
HTR6
SETD7
SETD7
Organism
Homo sapiens
Gene name
ADRA1A
Gene synonyms
ADRA1C
NCBI Gene ID
Protein name
alpha-1A adrenergic receptor
Protein synonyms
Alpha-1A adrenoceptor, Alpha-1A adrenoreceptor, Alpha-1C adrenergic receptor, Alpha-adrenergic receptor 1c, G protein coupled receptor
Uniprot ID
Mouse ortholog
Adra1a (11549)
alpha-1A adrenergic receptor (Q8BV77)
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
0 adverse events reported
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