Cyclacillin
Cyclapen-w (cyclacillin) is a small molecule pharmaceutical. Cyclacillin was first approved as Cyclapen-w on 1982-01-01. It is used to treat haemophilus infections, pneumococcal infections, respiratory tract infections, staphylococcal infections, and urinary tract infections in the USA.
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Therapeutic Areas
Therapeutic Area | MeSH |
|---|---|
| infections | D007239 |
| respiratory tract diseases | D012140 |
| urogenital diseases | D000091642 |
Trade Name
FDA
EMA
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Drug Products
FDA
EMA
Labels
FDA
EMA
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Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| haemophilus infections | EFO_1001127 | D006192 | — |
| pneumococcal infections | EFO_0000772 | D011008 | J13 |
| respiratory tract infections | — | D012141 | J06.9 |
| staphylococcal infections | — | D013203 | A49.01 |
| urinary tract infections | EFO_0003103 | D014552 | N39.0 |
Agency Specific
FDA
EMA
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Patent Expiration
No data
ATC Codes
No data
HCPCS
No data
Clinical
Clinical Trials
195 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Vitamin b 12 deficiency | D014806 | EFO_0000734 | E53.8 | 2 | 2 | 2 | 3 | 15 | 22 |
| Anemia | D000740 | EFO_0004272 | D64.9 | — | 3 | 2 | 4 | 5 | 12 |
| Cardiovascular diseases | D002318 | EFO_0000319 | I98 | — | 2 | 1 | 2 | — | 5 |
| Stroke | D020521 | EFO_0000712 | I63.9 | — | — | 2 | 1 | 2 | 5 |
| Myocardial infarction | D009203 | EFO_0000612 | I21 | — | 1 | 2 | 1 | — | 4 |
| Schizophrenia | D012559 | EFO_0000692 | F20 | — | 1 | 1 | 2 | 1 | 4 |
| Neoplasms | D009369 | C80 | — | — | 1 | 2 | — | 3 | |
| Vasoplegia | D056987 | — | 2 | — | 1 | — | 3 | ||
| Cognitive dysfunction | D060825 | G31.84 | 1 | — | — | 1 | 1 | 3 | |
| Iron-deficiency anemia | D018798 | HP_0001891 | D50 | — | — | — | 1 | 2 | 3 |
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Non-small-cell lung carcinoma | D002289 | 1 | 8 | 5 | — | 1 | 13 | ||
| Coronary artery disease | D003324 | I25.1 | — | 2 | 1 | — | 1 | 4 | |
| T-cell lymphoma peripheral | D016411 | C84.9 | 2 | 3 | 1 | — | — | 4 | |
| Autistic disorder | D001321 | EFO_0003758 | F84.0 | — | 2 | 2 | — | 2 | 4 |
| Covid-19 | D000086382 | U07.1 | — | 1 | 1 | — | 1 | 3 | |
| Lung neoplasms | D008175 | C34.90 | — | 3 | 1 | — | — | 3 | |
| Type 2 diabetes mellitus | D003924 | EFO_0001360 | E11 | — | 1 | 1 | — | 2 | 3 |
| Urinary bladder neoplasms | D001749 | C67 | — | 1 | 1 | — | — | 2 | |
| Transitional cell carcinoma | D002295 | — | 1 | 1 | — | — | 2 | ||
| Chronic kidney failure | D007676 | EFO_0003884 | N18.6 | — | — | 1 | — | 1 | 2 |
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Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Diabetic neuropathies | D003929 | EFO_1000783 | — | 1 | — | — | 4 | 5 | |
| Breast neoplasms | D001943 | EFO_0003869 | C50 | 1 | 2 | — | — | 1 | 4 |
| Systemic lupus erythematosus | D008180 | EFO_0002690 | M32 | — | 1 | — | — | 1 | 2 |
| Head and neck neoplasms | D006258 | — | 2 | — | — | — | 2 | ||
| Stomatitis | D013280 | EFO_1001904 | K12.1 | — | 2 | — | — | — | 2 |
| Nasopharyngeal neoplasms | D009303 | — | 2 | — | — | — | 2 | ||
| B-cell lymphoma | D016393 | 1 | 2 | — | — | — | 2 | ||
| Coronary disease | D003327 | — | 1 | — | — | — | 1 | ||
| Myocardial ischemia | D017202 | EFO_1001375 | I20-I25 | — | 1 | — | — | — | 1 |
| Heart diseases | D006331 | EFO_0003777 | I51.9 | — | 1 | — | — | — | 1 |
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Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Carpal tunnel syndrome | D002349 | EFO_0004143 | G56.0 | 1 | — | — | — | 2 | 3 |
| T-cell lymphoma cutaneous | D016410 | C84.A | 2 | — | — | — | — | 2 | |
| Obesity | D009765 | EFO_0001073 | E66.9 | 1 | — | — | — | 1 | 2 |
| Colorectal neoplasms | D015179 | 1 | — | — | — | — | 1 | ||
| Pancreatic ductal carcinoma | D021441 | 1 | — | — | — | — | 1 | ||
| Pancreatic neoplasms | D010190 | EFO_0003860 | C25 | 1 | — | — | — | — | 1 |
| Triple negative breast neoplasms | D064726 | 1 | — | — | — | — | 1 | ||
| Adenocarcinoma | D000230 | 1 | — | — | — | — | 1 | ||
| Sezary syndrome | D012751 | C84.1 | 1 | — | — | — | — | 1 | |
| Primary cutaneous anaplastic large cell lymphoma | D054446 | C86.6 | 1 | — | — | — | — | 1 |
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Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Healthy volunteers/patients | — | — | — | — | — | 3 | 3 | ||
| Diabetes mellitus | D003920 | EFO_0000400 | E08-E13 | — | — | — | — | 2 | 2 |
| Hyperhomocysteinemia | D020138 | — | — | — | — | 2 | 2 | ||
| Transient ischemic attack | D002546 | EFO_0003764 | G45.9 | — | — | — | — | 2 | 2 |
| Aphthous stomatitis | D013281 | EFO_0003938 | K12.0 | — | — | — | — | 2 | 2 |
| Pregnancy | D011247 | EFO_0002950 | Z33.1 | — | — | — | — | 2 | 2 |
| Diabetes complications | D048909 | — | — | — | — | 1 | 1 | ||
| Diabetic foot | D017719 | EFO_1001459 | — | — | — | — | 1 | 1 | |
| Delirium | D003693 | R41.0 | — | — | — | — | 1 | 1 | |
| Neutropenia | D009503 | D70 | — | — | — | — | 1 | 1 |
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | CYCLACILLIN |
| INN | ciclacillin |
| Description | Cyclacillin is a penicillin. It has a role as an antibacterial drug. |
| Classification | Small molecule |
| Drug class | penicillins |
| Image (chem structure or protein) | |
| Structure (InChI/SMILES or Protein Sequence) | CC1(C)S[C@@H]2[C@H](NC(=O)C3(N)CCCCC3)C(=O)N2[C@H]1C(=O)O |
Identifiers
| PDB | — |
| CAS-ID | 3485-14-1 |
| RxCUI | 2968 |
| ChEMBL ID | CHEMBL1200356 |
| ChEBI ID | 31444 |
| PubChem CID | 19003 |
| DrugBank | DB01000 |
| UNII ID | 72ZJ154X86 (ChemIDplus, GSRS) |
Target
Agency Approved
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Alternate
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Variants
Clinical Variant
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Financial
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Trends
PubMed Central
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Safety
Black-box Warning
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Adverse Events
Top Adverse Reactions
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3,354 adverse events reported
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