Cyanocobalamin

Berocca Pn, Depinar, Dicopac, Infuvite, M.v.c. 9+, M.v.i, M.v.i. Lyophilized, Mvc, Nascobal, Vitaped (cyanocobalamin) is a small molecule pharmaceutical. Cyanocobalamin was first approved as Vi-twel on 1982-01-01.

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Commercial

Therapeutic Areas

No data

Trade Name

FDA

EMA

Nascobal (generic drugs available since 1982-01-01, discontinued: Berubigen, Betalin, Calomist, Cobavite, Redisol, Rubivite, Rubramin pc, Ruvite, Vi-twel)

Combinations

Infuvite (discontinued: Berocca pn, Depinar, Dicopac, M.v.c. 9+, M.v.i., M.v.i. lyophilized, Mvc, Vitaped)

Drug Products

FDA

EMA

New Drug Application (NDA)

Abbreviated New Drug Application (ANDA)

Alpha-tocopherol acetate

Ascorbic acid

Biotin

Cholecalciferol

Cyanocobalamin

Dexpanthenol

Folic acid

Niacinamide

Pyridoxine hydrochloride

Riboflavin 5'-phosphate sodium

Thiamine hydrochloride

Vitamin a palmitate

Vitamin k

Tradename	Company	Number	Date	Products
INFUVITE ADULT	Sandoz	N-021163 RX	2000-05-18	2 products, RLD, RS

Ascorbic acid

Biotin

Cholecalciferol

Cyanocobalamin

Dexpanthenol

Folic acid

Niacinamide

Pyridoxine

Riboflavin

Thiamine

Tocopherol acetate

Vitamin a

Vitamin k

Tradename	Company	Number	Date	Products
INFUVITE PEDIATRIC (PHARMACY BULK PACKAGE)	Sandoz	N-021265 RX	2004-01-29	1 products, RLD, RS
INFUVITE PEDIATRIC	Sandoz	N-021265 RX	2001-02-21	1 products, RLD, RS

Ascorbic acid

Biotin

Cyanocobalamin

Dexpanthenol

Ergocalciferol

Folic acid

Niacinamide

Phytonadione

Pyridoxine hydrochloride

Riboflavin 5'-phosphate sodium

Thiamine hydrochloride

Vitamin a

Vitamin e

Tradename	Company	Number	Date	Products
M.V.I. PEDIATRIC	Hospira	N-018920 DISCN	2000-09-21	1 products, RLD

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Ascorbic acid

Biotin

Cyanocobalamin

Dexpanthenol

Ergocalciferol

Folic acid

Niacinamide

Pyridoxine

Riboflavin 5'-phosphate sodium

Thiamine

Vitamin a

Vitamin e

Tradename	Company	Number	Date	Products
M.V.I.-12 LYOPHILIZED	Teligent	N-018933 DISCN	1985-08-08	1 products

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Ascorbic acid

Biotin

Cyanocobalamin

Dexpanthenol

Ergocalciferol

Folic acid

Niacinamide

Pyridoxine hydrochloride

Riboflavin

Thiamine hydrochloride

Vitamin a

Vitamin e

Tradename	Company	Number	Date	Products
M.V.I.-12 ADULT	Hospira	N-008809 DISCN	2004-04-22	1 products

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Ascorbic acid

Biotin

Cyanocobalamin

Dexpanthenol

Ergocalciferol

Folic acid

Niacinamide

Pyridoxine hydrochloride

Riboflavin 5'-phosphate sodium

Thiamine hydrochloride

Vitamin a

Vitamin e

Tradename	Company	Number	Date	Products
M.V.C. 9+3	APP Pharmaceuticals	N-018440 DISCN	1985-08-08	1 products
M.V.I.-12 ADULT	Hospira	N-008809 DISCN	1985-08-08	2 products
MVC PLUS	Allergan	N-018439 DISCN	1985-08-08	1 products

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Ascorbic acid

Biotin

Cyanocobalamin

Dexpanthenol

Ergocalciferol

Folic acid

Niacinamide

Pyridoxine hydrochloride

Riboflavin 5'-phosphate sodium

Thiamine hydrochloride

Vitamin a

Vitamin e

Vitamin k

Tradename	Company	Number	Date	Products
M.V.I. ADULT	Hospira	N-021625 DISCN	2004-01-30	1 products, RLD
M.V.I. ADULT (PHARMACY BULK PACKAGE)	Hospira	N-021643 DISCN	2004-02-18	1 products, RLD

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Ascorbic acid

Biotin

Cyanocobalamin

Dexpanthenol

Ergocalciferol

Folic acid

Niacinamide

Pyridoxine hydrochloride

Riboflavin 5'-phosphate sodium

Thiamine hydrochloride

Vitamin a palmitate

Vitamin e

Tradename	Company	Number	Date	Products
BEROCCA PN	Roche	N-006071 DISCN	1985-10-10	1 products

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Ascorbic acid

Biotin

Cyanocobalamin

Ergocalciferol

Folic acid

Niacinamide

Pantothenic acid

Phytonadione

Pyridoxine

Riboflavin

Thiamine

Vitamin a palmitate

Vitamin e

Tradename	Company	Number	Date	Products
VITAPED	Hospira	N-020176 DISCN	1993-12-29	1 products

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Cyanocobalamin

Tradename	Company	Number	Date	Products
NASCOBAL	Endo	N-021642 RX	2005-01-31	1 products, RLD, RS

Show 8 discontinued

Cyanocobalamin

Cyanocobalamin co-57

Cyanocobalamin co-58

Tradename	Company	Number	Date	Products
DICOPAC KIT	GE Healthcare	N-017406 DISCN	1982-01-01	1 products

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Cyanocobalamin

Tannic acid

Zinc acetate

Tradename	Company	Number	Date	Products
DEPINAR	Armour Pharmaceutical	N-011208 DISCN	1982-01-01	1 products

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Labels

FDA

EMA

Brand Name	Status	Last Update
adult infuvite multiple vitamins	New Drug Application	2016-10-28
cyanocobalamine	ANDA	2023-06-09
dodex injectable	ANDA	2022-04-06
nascobal	New Drug Application	2020-02-07

Indications

FDA

EMA

No data

Agency Specific

FDA

EMA

No data

Patent Expiration

Patent	Expires	Flag	FDA Information
Cyanocobalamin, Nascobal, Endo Pharms Inc
7229636	2024-08-01	DP	U-817
7879349	2024-08-01	DP	U-1152
8003353	2024-08-01		U-817
9415007	2024-07-28		U-1896
7404489	2024-03-12	DP
8940714	2024-02-26		U-1152

ATC Codes

B: Blood and blood forming organ drugs

— B03: Antianemic preparations

— B03B: Vitamin b12 and folic acid

— B03BA: Vitamin b12 (cyanocobalamin and analogues)

— B03BA01: Cyanocobalamin

— B03BA02: Cyanocobalamin tannin complex

— B03BA51: Cyanocobalamin, combinations

V: Various drug classes in atc

— V09: Diagnostic radiopharmaceuticals

— V09X: Other diagnostic radiopharmaceuticals in atc

— V09XX: Various diagnostic radiopharmaceuticals

— V09XX01: Cobalt (57co) cyanocobalamine

— V09XX02: Cobalt (58co) cyanocobalamine

HCPCS

Code	Description
A9546	Cobalt co-57/58, cyanocobalamin, diagnostic, per study dose, up to 1 microcurie
A9559	Cobalt co-57 cyanocobalamin, oral, diagnostic, per study dose, up to 1 microcurie
J3420	Injection, vitamin b-12 cyanocobalamin, up to 1000 mcg

Clinical

Indications Phases 4

No data

Indications Phases 3

No data

Indications Phases 2

No data

Indications Phases 1

No data

Indications Without Phase

No data

Epidemiology

Epidemiological information for investigational and approved indications

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Drug

General

Drug common name	CYANOCOBALAMIN
INN	cyanocobalamin
Description	Cyanocobalamin is a form of vitamin B12 used to treat vitamin B12 deficiency except in the presence of cyanide toxicity. The deficiency may occur in pernicious anemia, following surgical removal of the stomach, with fish tapeworm, or due to bowel cancer. It is less preferred than hydroxocobalamin for treating vitamin B12 deficiency. Some study have shown that it has an antihypotensive effect. It is used by mouth, by injection into a muscle, or as a nasal spray.
Classification	Small molecule
Drug class	—
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)	C/C1=C2/N=C(/C=C3\N=C(/C(C)=C4\[N-]C([C@H](CC(N)=O)[C@@]4(C)CCC(=O)NC[C@@H](C)OP(=O)([O-])O[C@@H]4[C@@H](CO)O[C@H](n5cnc6cc(C)c(C)cc65)[C@@H]4O)[C@]4(C)N=C1[C@@H](CCC(N)=O)[C@]4(C)CC(N)=O)[C@@H](CCC(N)=O)C3(C)C)[C@@H](CCC(N)=O)[C@]2(C)CC(N)=O.[C-]#N.[Co+3]

Identifiers

PDB	—
CAS-ID	68-19-9
RxCUI	11248
ChEMBL ID	CHEMBL2110563
ChEBI ID	—
PubChem CID	16212801
DrugBank	DB00115
UNII ID	P6YC3EG204 (ChemIDplus, GSRS)

Target

Agency Approved

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Alternate

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Variants

Clinical Variant

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Financial

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Safety

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