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Conestat alfa
Ruconest (conestat alfa) is a protein pharmaceutical. Conestat alfa was first approved as Ruconest on 2010-10-28. It has been approved in Europe to treat hereditary angioedemas.
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
cardiovascular diseasesD002318
hereditary congenital and neonatal diseases and abnormalitiesD009358
skin and connective tissue diseasesD017437
immune system diseasesD007154
Trade Name
FDA
EMA
No data
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
No data
Labels
FDA
EMA
Brand Name
Status
Last Update
ruconestBiologic Licensing Application2022-10-24
Indications
FDA
EMA
No data
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
B: Blood and blood forming organ drugs
B06: Other hematological agents in atc
B06A: Other hematological agents in atc
B06AC: Drugs used in hereditary angioedema
B06AC04: Conestat alfa
HCPCS
No data
Clinical
Clinical Trials
61 clinical trials
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Indications Phases 4
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Hereditary angioedemasD054179EFO_000413129131123
Hereditary angioedema types i and iiD056829222117
Covid-19D000086382U07.1112
Common variable immunodeficiencyD017074EFO_0000367D8311
AsthmaD001249EFO_0000270J4511
Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
AngioedemaD000799EFO_0005532T78.3345
Inborn genetic diseasesD030342EFO_0000508324
InflammationD007249213
SepsisD018805A41.922
EndotoxemiaD019446112
Multiple organ failureD009102EFO_1001373112
Innate immunityD00711311
Wounds and injuriesD014947T14.811
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Reperfusion injuryD015427223
Renal insufficiencyD051437HP_0000083N19212
Kidney transplantationD016030122
Chronic kidney failureD007676EFO_0003884N18.6222
Acute kidney injuryD058186HP_0001919N1722
Graft rejectionD00608422
Ischemic strokeD000083242112
Coronavirus infectionsD018352EFO_0007224B34.211
Chronic renal insufficiencyD051436N18111
Traumatic brain injuriesD000070642S0611
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Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Neuromyelitis opticaD009471EFO_0004256G36.011
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameCONESTAT ALFA
INNconestat alfa
Description
Ruconest (conestat alfa) is a protein pharmaceutical. Conestat alfa was first approved as Ruconest on 2010-10-28. It has been approved in Europe to treat hereditary angioedemas.
Classification
Protein
Drug classenzyme inhibitors
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
Identifiers
PDB
CAS-ID
RxCUI
ChEMBL IDCHEMBL2108350
ChEBI ID
PubChem CID
DrugBankDB06404
UNII ID5QS67N4551 (ChemIDplus, GSRS)
Target
Agency Approved
No data
Alternate
No data
Variants
Clinical Variant
No data
Financial
Ruconest - Pharming
$
£
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Tabular view
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 289 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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3,555 adverse events reported
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