Clozapine
Clozaril, Versacloz (clozapine) is a small molecule pharmaceutical. Clozapine was first approved as Clozaril on 1989-09-26. It is used to treat bipolar disorder, psychotic disorders, schizophrenia, and schizophrenia spectrum and other psychotic disorders in the USA. The pharmaceutical is active against D(2) dopamine receptor and 5-hydroxytryptamine receptor 2A. In addition, it is known to target D(1B) dopamine receptor, alpha-1D adrenergic receptor, 5-hydroxytryptamine receptor 6, 5-hydroxytryptamine receptor 5A, 5-hydroxytryptamine receptor 1D, histamine H4 receptor, 5-hydroxytryptamine receptor 1F, D(4) dopamine receptor, D(1A) dopamine receptor, 5-hydroxytryptamine receptor 1A, 5-hydroxytryptamine receptor 2C, 5-hydroxytryptamine receptor 1E, 5-hydroxytryptamine receptor 1B, alpha-1A adrenergic receptor, alpha-1B adrenergic receptor, 5-hydroxytryptamine receptor 7, 5-hydroxytryptamine receptor 2B, D(3) dopamine receptor, histamine H1 receptor, muscarinic acetylcholine receptor M1, G protein-activated inward rectifier potassium channel 2, and histamine H3 receptor.
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Commercial
Therapeutic Areas
Therapeutic Area | MeSH |
|---|---|
| mental disorders | D001523 |
Trade Name
FDA
EMA
Clozaril, Versacloz (generic drugs available since 1997-11-26, discontinued: Fazaclo)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| bipolar disorder | EFO_0000289 | D001714 | F30.9 |
| psychotic disorders | — | D011618 | F20.81 |
| schizophrenia | EFO_0000692 | D012559 | F20 |
| schizophrenia spectrum and other psychotic disorders | — | D019967 | — |
Agency Specific
FDA
EMA
No data
Patent Expiration
Patent | Expires | Flag | FDA Information |
|---|---|---|---|
| Clozapine, Versacloz, Tasman Pharma | |||
| 8057811 | 2028-05-01 | DP | |
HCPCS
Code | Description |
|---|---|
| S0136 | Clozapine, 25 mg |
Clinical
Clinical Trials
18 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Epilepsy | D004827 | EFO_0000474 | G40.9 | — | 3 | 2 | 3 | 1 | 9 |
| Anxiety | D001007 | EFO_0005230 | F41.1 | — | — | — | 1 | — | 1 |
| Drug resistant epilepsy | D000069279 | — | — | — | 1 | — | 1 |
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Myoclonic epilepsies | D004831 | EFO_1001900 | G40.4 | — | — | 2 | — | — | 2 |
| Seizures | D012640 | G40.4 | — | 1 | 1 | — | — | 2 | |
| Generalized epilepsy | D004829 | — | 1 | 1 | — | — | 2 | ||
| Dementia | D003704 | F03 | — | — | 1 | — | — | 1 | |
| Psychophysiologic disorders | D011602 | F45.9 | — | — | 1 | — | — | 1 | |
| Schizophrenia | D012559 | EFO_0000692 | F20 | — | — | 1 | — | — | 1 |
| Depression | D003863 | F33.9 | — | — | 1 | — | — | 1 | |
| Anxiety disorders | D001008 | EFO_0006788 | F41.1 | — | — | 1 | — | — | 1 |
| Low back pain | D017116 | HP_0003419 | M54.5 | — | — | 1 | — | — | 1 |
| Pain | D010146 | EFO_0003843 | R52 | — | — | 1 | — | — | 1 |
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Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Neuralgia | D009437 | EFO_0009430 | 1 | 1 | — | — | — | 1 |
Indications Phases 1
No data
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | CLOZAPINE |
| INN | clozapine |
| Description | Clozapine is a benzodiazepine that is 5H-dibenzo[b,e][1,4]diazepine substituted by a chloro group at position 8 and a 4-methylpiperazin-1-yl group at position 11. It is a second generation antipsychotic used in the treatment of psychiatric disorders like schizophrenia. It has a role as a serotonergic antagonist, a dopaminergic antagonist, an adrenergic antagonist, a histamine antagonist, a muscarinic antagonist, a second generation antipsychotic, a GABA antagonist, an EC 3.4.21.26 (prolyl oligopeptidase) inhibitor, a xenobiotic and an environmental contaminant. It is a benzodiazepine, a N-methylpiperazine, a N-arylpiperazine and an organochlorine compound. |
| Classification | Small molecule |
| Drug class | tricyclic compounds |
| Image (chem structure or protein) | |
| Structure (InChI/SMILES or Protein Sequence) | CN1CCN(C2=Nc3cc(Cl)ccc3Nc3ccccc32)CC1 |
Identifiers
| PDB | — |
| CAS-ID | 5786-21-0 |
| RxCUI | 2626 |
| ChEMBL ID | CHEMBL42 |
| ChEBI ID | 3766 |
| PubChem CID | 135398737 |
| DrugBank | DB00363 |
| UNII ID | J60AR2IKIC (ChemIDplus, GSRS) |
Target
Alternate
DRD5
DRD5
ADRA1D
ADRA1D
HTR6
HTR6
HTR5A
HTR5A
HTR1D
HTR1D
HRH4
HRH4
HTR1F
HTR1F
DRD4
DRD4
DRD1
DRD1
HTR1A
HTR1A
HTR2C
HTR2C
HTR1E
HTR1E
HTR1B
HTR1B
ADRA1A
ADRA1A
ADRA1B
ADRA1B
HTR7
HTR7
HTR2B
HTR2B
DRD3
DRD3
HRH1
HRH1
CHRM1
CHRM1
KCNJ6
KCNJ6
HRH3
HRH3
Variants
Clinical Variant
No data
Financial
Fazaclo - Jazz Pharmaceuticals
$
€
£
₣
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Tabular view
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 23,227 documents
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Safety
Black-box Warning
Black-box warning for: Clozapine, Clozaril, Versacloz
Adverse Events
Top Adverse Reactions
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8,635 adverse events reported
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