Clotrimazole
Lotrisone, Trivagizole (clotrimazole) is a small molecule pharmaceutical. Clotrimazole was first approved as Mycelex on 1982-01-01. It is used to treat cutaneous candidiasis, mycoses, oral candidiasis, tinea pedis, and vulvovaginal candidiasis in the USA. It is known to target transient receptor potential cation channel subfamily M member 2, transient receptor potential cation channel subfamily M member 4, nuclear receptor subfamily 1 group I member 3, intermediate conductance calcium-activated potassium channel protein 4, nuclear receptor subfamily 1 group I member 2, and transient receptor potential cation channel subfamily M member 8.
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Therapeutic Areas
Therapeutic Area | MeSH |
|---|---|
| infections | D007239 |
| stomatognathic diseases | D009057 |
| urogenital diseases | D000091642 |
| skin and connective tissue diseases | D017437 |
| signs and symptoms pathological conditions | D013568 |
Trade Name
FDA
EMA
Trivagizole (generic drugs available since 1993-07-16, discontinued: Gyne-lotrimin, Gynix, Lotrimin, Mycelex)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Betamethasone dipropionate
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Clotrimazole
Clotrimazole
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| TRIVAGIZOLE 3 | Taro Pharmaceutical | N-021143 OTC | 2000-04-12 | 1 products |
Show 16 discontinued
Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| cutaneous candidiasis | — | D002179 | — |
| mycoses | — | D009181 | B35-B49 |
| oral candidiasis | EFO_0007406 | D002180 | B37.0 |
| tinea pedis | EFO_0007512 | D014008 | B35.3 |
| vulvovaginal candidiasis | EFO_0007543 | D002181 | B37.3 |
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
A: Alimentary tract and metabolism drugs
— A01: Stomatological preparations
— A01A: Stomatological preparations
— A01AB: Antiinfectives and antiseptics for local oral treatment
— A01AB18: Clotrimazole
D: Dermatologicals
— D01: Antifungals for dermatological use
— D01A: Antifungals for topical use
— D01AC: Imidazole and triazole derivatives, topical antifungals
— D01AC01: Clotrimazole
G: Genito urinary system and sex hormones
— G01: Gynecological antiinfectives and antiseptics
— G01A: Antiinfectives and antiseptics, excl. combinations with corticosteroids
— G01AF: Imidazole derivatives, gyncological antiinfectives
— G01AF02: Clotrimazole
HCPCS
No data
Clinical
Clinical Trials
93 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Vulvovaginal candidiasis | D002181 | EFO_0007543 | B37.3 | 1 | 3 | 3 | 5 | 1 | 11 |
| Bacterial vaginosis | D016585 | EFO_0003932 | 1 | 1 | 1 | 1 | 1 | 5 | |
| Candidiasis | D002177 | B37 | — | 1 | 2 | 1 | — | 4 | |
| Invasive fungal infections | D000072742 | — | — | — | 1 | 2 | 3 | ||
| Onychomycosis | D014009 | B35.1 | — | — | — | 1 | 1 | 2 | |
| Hyperlipoproteinemia type ii | D006938 | EFO_0004911 | E78.00 | — | — | — | 1 | — | 1 |
| Burns | D002056 | T30.0 | — | — | — | 1 | — | 1 | |
| Atopic dermatitis | D003876 | EFO_0000274 | L20 | — | — | — | 1 | — | 1 |
| Eczematous skin diseases | D017443 | — | — | — | 1 | — | 1 | ||
| Chronic kidney failure | D007676 | EFO_0003884 | N18.6 | — | — | — | 1 | — | 1 |
Show 2 more
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Otomycosis | D059249 | — | 2 | 5 | — | 2 | 8 | ||
| Mycoses | D009181 | B35-B49 | — | 2 | 3 | — | 2 | 6 | |
| Oral candidiasis | D002180 | EFO_0007406 | B37.0 | — | 1 | 2 | — | 1 | 4 |
| Tinea pedis | D014008 | EFO_0007512 | B35.3 | 3 | — | 1 | — | — | 4 |
| Hiv infections | D015658 | EFO_0000764 | B20 | — | — | 2 | — | 1 | 3 |
| Tinea | D014005 | EFO_0007510 | B35.4 | — | — | 2 | — | — | 2 |
| Tinea cruris | D000084002 | B35.6 | — | 1 | 1 | — | — | 2 | |
| Denture stomatitis | D013282 | EFO_1000893 | K12.1 | — | 1 | 1 | — | — | 2 |
| Intraabdominal infections | D059413 | — | — | 1 | — | — | 1 | ||
| Folliculitis | D005499 | — | 1 | 1 | — | — | 1 |
Show 4 more
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Invasive pulmonary aspergillosis | D055744 | B44.0 | — | 1 | — | — | 2 | 3 | |
| Sickle cell anemia | D000755 | EFO_0000697 | D57 | 1 | 1 | — | — | 1 | 2 |
| Myelodysplastic syndromes | D009190 | D46 | — | 1 | — | — | 1 | 2 | |
| Stomatitis | D013280 | EFO_1001904 | K12.1 | — | 2 | — | — | — | 2 |
| Neoplasms | D009369 | C80 | — | 1 | — | — | — | 1 | |
| Leukemia | D007938 | C95 | — | 1 | — | — | — | 1 | |
| Hematologic neoplasms | D019337 | — | 1 | — | — | — | 1 | ||
| Graft vs host disease | D006086 | D89.81 | — | 1 | — | — | — | 1 | |
| Kidney diseases | D007674 | EFO_0003086 | N08 | 1 | 1 | — | — | — | 1 |
| Kidney transplantation | D016030 | 1 | 1 | — | — | — | 1 |
Show 7 more
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Invasive candidiasis | D058365 | EFO_1001283 | B37 | — | — | — | — | 1 | 1 |
| Type 1 diabetes mellitus | D003922 | EFO_0001359 | E10 | — | — | — | — | 1 | 1 |
| Invasive hydatidiform mole | D002820 | D39.2 | — | — | — | — | 1 | 1 | |
| Fusariosis | D060585 | EFO_1001795 | — | — | — | — | 1 | 1 | |
| Hypercholesterolemia | D006937 | HP_0003124 | — | — | — | — | 1 | 1 | |
| Corneal ulcer | D003320 | H16.0 | — | — | — | — | 1 | 1 | |
| Sepsis | D018805 | A41.9 | — | — | — | — | 1 | 1 | |
| Laser therapy | D053685 | — | — | — | — | 1 | 1 | ||
| Lichen planus | D008010 | L43 | — | — | — | — | 1 | 1 | |
| Recurrence | D012008 | — | — | — | — | 1 | 1 |
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | CLOTRIMAZOLE |
| INN | clotrimazole |
| Description | Clotrimazole is a member of the class of imidazoles that is 1H-imidazole in which the hydrogen attached to a nitrogen is replaced by a monochlorotrityl group. It has a role as an antiinfective agent, an environmental contaminant and a xenobiotic. It is a member of imidazoles, a member of monochlorobenzenes, a conazole antifungal drug and an imidazole antifungal drug. |
| Classification | Small molecule |
| Drug class | — |
| Image (chem structure or protein) | |
| Structure (InChI/SMILES or Protein Sequence) | Clc1ccccc1C(c1ccccc1)(c1ccccc1)n1ccnc1 |
Target
Agency Approved
No data
Alternate
TRPM2
TRPM2
TRPM4
TRPM4
NR1I3
NR1I3
KCNN4
KCNN4
NR1I2
NR1I2
TRPM8
TRPM8
Organism
Homo sapiens
Gene name
TRPM2
Gene synonyms
EREG1, KNP3, LTRPC2, TRPC7
NCBI Gene ID
Protein name
transient receptor potential cation channel subfamily M member 2
Protein synonyms
Estrogen-responsive element-associated gene 1 protein, Long transient receptor potential channel 2, LTrpC-2, LTrpC2, Transient receptor potential channel 7, Transient receptor potential melastatin 2, TrpC7
Uniprot ID
Mouse ortholog
Trpm2 (28240)
transient receptor potential cation channel subfamily M member 2 (Q91YD4)
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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4,215 adverse events reported
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