Clorazepic acid
Tranxene (clorazepic acid) is a small molecule pharmaceutical. Clorazepic acid was first approved as Tranxene on 1982-01-01. It is used to treat alcohol withdrawal delirium, anxiety disorders, and partial epilepsies in the USA.
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Commercial
Trade Name
FDA
EMA
Tranxene (generic drugs available since 1987-07-17, discontinued: Gen-xene)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Clorazepate dipotassium
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| TRANXENE | Key Therapeutics | N-017105 RX | 1982-01-01 | 1 products, RLD |
Show 3 discontinued
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| clorazepate dipotassium | ANDA | 2023-04-14 |
Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| alcohol withdrawal delirium | EFO_1000800 | D000430 | — |
| anxiety disorders | EFO_0006788 | D001008 | F41.1 |
| partial epilepsies | EFO_0004263 | D004828 | — |
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
HCPCS
No data
Clinical
Clinical Trials
159 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Infertility | D007246 | EFO_0000545 | 3 | 9 | 11 | 23 | 15 | 54 | |
| Polycystic ovary syndrome | D011085 | EFO_0000660 | E28.2 | 2 | 9 | 10 | 16 | 17 | 50 |
| Anovulation | D000858 | 1 | 2 | 2 | 4 | 1 | 10 | ||
| Ovulation induction | D010062 | — | — | 2 | 3 | 1 | 6 | ||
| Female infertility | D007247 | EFO_0008560 | N97 | 1 | 1 | 1 | 3 | 1 | 6 |
| Pregnancy | D011247 | EFO_0002950 | Z33.1 | — | — | 3 | 2 | — | 5 |
| Vitamin d deficiency | D014808 | EFO_0003762 | E55 | 1 | 1 | — | 1 | 1 | 3 |
| Fertilization in vitro | D005307 | — | — | — | 1 | — | 1 |
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Hypogonadism | D007006 | E23.0 | 3 | 10 | 8 | — | 1 | 22 | |
| Hyperandrogenism | D017588 | — | 2 | 1 | — | — | 3 | ||
| Azoospermia | D053713 | EFO_0000279 | N46.0 | — | — | 1 | — | — | 1 |
| Insulin resistance | D007333 | EFO_0002614 | — | — | 1 | — | — | 1 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Eunuchism | D005058 | EFO_0007266 | E29.1 | — | 2 | — | — | — | 2 |
| Primary ovarian insufficiency | D016649 | EFO_0004266 | E28.3 | — | 2 | — | — | — | 2 |
| Obesity | D009765 | EFO_0001073 | E66.9 | — | 2 | — | — | — | 2 |
| Type 2 diabetes mellitus | D003924 | EFO_0001360 | E11 | — | 2 | — | — | — | 2 |
| Hyperprolactinemia | D006966 | E22.1 | — | 1 | — | — | — | 1 | |
| Opioid-related disorders | D009293 | EFO_0005611 | F11 | — | 1 | — | — | — | 1 |
| Male infertility | D007248 | EFO_0004248 | N46 | — | 1 | — | — | — | 1 |
| Acromegaly | D000172 | — | 1 | — | — | — | 1 | ||
| Prolactinoma | D015175 | HP_0006767 | — | 1 | — | — | — | 1 | |
| Rotator cuff injuries | D000070636 | M75.1 | — | 1 | — | — | — | 1 |
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Pharmacokinetics | D010599 | 2 | — | — | — | — | 2 | ||
| Leiomyoma | D007889 | HP_0000131 | D25 | 1 | — | — | — | — | 1 |
| Substance-related disorders | D019966 | EFO_0003890 | F13 | 1 | — | — | — | — | 1 |
| Healthy volunteers/patients | — | 1 | — | — | — | — | 1 | ||
| Drug interactions | D004347 | 1 | — | — | — | — | 1 | ||
| Therapeutic equivalency | D013810 | 1 | — | — | — | — | 1 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Hyperinsulinism | D006946 | HP_0000842 | E16.1 | — | — | — | — | 2 | 2 |
| Pregnancy rate | D018873 | — | — | — | — | 1 | 1 | ||
| Endometriosis | D004715 | EFO_0001065 | N80 | — | — | — | — | 1 | 1 |
| Asymptomatic diseases | D058070 | — | — | — | — | 1 | 1 | ||
| Affect | D000339 | — | — | — | — | 1 | 1 |
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | CLORAZEPIC ACID |
| INN | dipotassium clorazepate |
| Description | Clorazepic acid is a 1,4-benzodiazepinone in which the oxo group is at position 2, and which is substituted at positions 3, 5, and 7 by carboxy, phenyl and chloro groups, respectively. It has a role as a prodrug, an anticonvulsant, an anxiolytic drug and a GABA modulator. It is a conjugate acid of a clorazepic acid anion. |
| Classification | Small molecule |
| Drug class | — |
| Image (chem structure or protein) | |
| Structure (InChI/SMILES or Protein Sequence) | O=C(O)C1N=C(c2ccccc2)c2cc(Cl)ccc2NC1=O |
Identifiers
| PDB | — |
| CAS-ID | 23887-31-2 |
| RxCUI | 2353 |
| ChEMBL ID | CHEMBL1213252 |
| ChEBI ID | 3761 |
| PubChem CID | 2809 |
| DrugBank | DB00628 |
| UNII ID | 63FN7G03XY (ChemIDplus, GSRS) |
Target
Agency Approved
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Alternate
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Variants
Clinical Variant
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Financial
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Trends
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Additional graphs summarizing 234 documents
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Safety
Black-box Warning
Black-box warning for: Clorazepate dipotassium
Adverse Events
Top Adverse Reactions
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1,207 adverse events reported
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