Skip to content
Clorazepic acid
Tranxene (clorazepic acid) is a small molecule pharmaceutical. Clorazepic acid was first approved as Tranxene on 1982-01-01. It is used to treat alcohol withdrawal delirium, anxiety disorders, and partial epilepsies in the USA.
Download report
Favorite
Commercial
Therapeutic Areas
Therapeutic Area
MeSH
nervous system diseasesD009422
chemically-induced disordersD064419
mental disordersD001523
Trade Name
FDA
EMA
Tranxene (generic drugs available since 1987-07-17, discontinued: Gen-xene)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Clorazepate dipotassium
Tradename
Company
Number
Date
Products
TRANXENEKey TherapeuticsN-017105 RX1982-01-01
1 products, RLD
Show 3 discontinued
Labels
FDA
EMA
Brand Name
Status
Last Update
clorazepate dipotassiumANDA2023-04-14
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
alcohol withdrawal deliriumEFO_1000800D000430
anxiety disordersEFO_0006788D001008F41.1
partial epilepsiesEFO_0004263D004828
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
N: Nervous system drugs
N05: Psycholeptics
N05B: Anxiolytics
N05BA: Benzodiazepine derivative anxiolytics
N05BA05: Potassium clorazepate
HCPCS
No data
Clinical
Clinical Trials
159 clinical trials
View more details
Mock data
Subscribe for the real data
Indications Phases 4
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
InfertilityD007246EFO_00005453911231554
Polycystic ovary syndromeD011085EFO_0000660E28.22910161750
AnovulationD0008581224110
Ovulation inductionD0100622316
Female infertilityD007247EFO_0008560N97111316
PregnancyD011247EFO_0002950Z33.1325
Vitamin d deficiencyD014808EFO_0003762E5511113
Fertilization in vitroD00530711
Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
HypogonadismD007006E23.03108122
HyperandrogenismD017588213
AzoospermiaD053713EFO_0000279N46.011
Insulin resistanceD007333EFO_000261411
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
EunuchismD005058EFO_0007266E29.122
Primary ovarian insufficiencyD016649EFO_0004266E28.322
ObesityD009765EFO_0001073E66.922
Type 2 diabetes mellitusD003924EFO_0001360E1122
HyperprolactinemiaD006966E22.111
Opioid-related disordersD009293EFO_0005611F1111
Male infertilityD007248EFO_0004248N4611
AcromegalyD00017211
ProlactinomaD015175HP_000676711
Rotator cuff injuriesD000070636M75.111
Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
PharmacokineticsD01059922
LeiomyomaD007889HP_0000131D2511
Substance-related disordersD019966EFO_0003890F1311
Healthy volunteers/patients11
Drug interactionsD00434711
Therapeutic equivalencyD01381011
Indications Without Phase
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
HyperinsulinismD006946HP_0000842E16.122
Pregnancy rateD01887311
EndometriosisD004715EFO_0001065N8011
Asymptomatic diseasesD05807011
AffectD00033911
Epidemiology
Epidemiological information for investigational and approved indications
View more details
Drug
General
Drug common nameCLORAZEPIC ACID
INNdipotassium clorazepate
Description
Clorazepic acid is a 1,4-benzodiazepinone in which the oxo group is at position 2, and which is substituted at positions 3, 5, and 7 by carboxy, phenyl and chloro groups, respectively. It has a role as a prodrug, an anticonvulsant, an anxiolytic drug and a GABA modulator. It is a conjugate acid of a clorazepic acid anion.
Classification
Small molecule
Drug class
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
O=C(O)C1N=C(c2ccccc2)c2cc(Cl)ccc2NC1=O
Identifiers
PDB
CAS-ID23887-31-2
RxCUI2353
ChEMBL IDCHEMBL1213252
ChEBI ID3761
PubChem CID2809
DrugBankDB00628
UNII ID63FN7G03XY (ChemIDplus, GSRS)
Target
Agency Approved
No data
Alternate
No data
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
Mock data
Subscribe for the real data
Additional graphs summarizing 234 documents
View more details
Safety
Black-box Warning
Black-box warning for: Clorazepate dipotassium
Adverse Events
Top Adverse Reactions
Mock data
Subscribe for the real data
1,207 adverse events reported
View more details