Clomiphene
Clomid, Milophene, Serophene (clomiphene) is a small molecule pharmaceutical. Clomiphene was first approved as Clomid on 1982-01-01. It is used to treat female infertility and male infertility in the USA. The pharmaceutical is active against estrogen receptor.
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Commercial
Therapeutic Areas
Therapeutic Area | MeSH |
|---|---|
| urogenital diseases | D000091642 |
Trade Name
FDA
EMA
No data
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| clomid | ANDA | 2023-05-31 |
Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| female infertility | EFO_0008560 | D007247 | N97 |
| male infertility | EFO_0004248 | D007248 | N46 |
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
HCPCS
Code | Description |
|---|---|
| G9940 | Documentation of medical reason(s) for not on a statin (e.g., pregnancy, in vitro fertilization, clomiphene rx, esrd, cirrhosis, muscular pain and disease during the measurement period or prior year) |
Clinical
Clinical Trials
85 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Psoriasis | D011565 | EFO_0000676 | L40 | 6 | 3 | 4 | 13 | 2 | 27 |
| Vulvar lichen sclerosus | D007724 | N90.4 | — | 3 | 2 | 1 | 2 | 8 | |
| Bullous pemphigoid | D010391 | EFO_0007187 | L12 | — | 1 | 1 | 2 | — | 4 |
| Alopecia areata | D000506 | EFO_0004192 | L63 | — | — | 1 | 1 | — | 2 |
| Contact dermatitis | D003877 | L25 | — | — | — | 1 | — | 1 | |
| Occupational dermatitis | D009783 | — | — | — | 1 | — | 1 | ||
| Osteoporosis | D010024 | EFO_0003882 | M81.0 | — | — | — | 1 | — | 1 |
| Hypertrophic cicatrix | D017439 | L91.0 | — | — | — | 1 | — | 1 | |
| Photosensitivity disorders | D010787 | L57.1 | — | — | — | 1 | — | 1 | |
| Alopecia | D000505 | HP_0002293 | L64 | — | — | — | 1 | — | 1 |
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Oral lichen planus | D017676 | — | 5 | 1 | — | 1 | 6 | ||
| Lichen sclerosus et atrophicus | D018459 | L90.0 | — | 1 | 1 | — | — | 2 | |
| Cataract | D002386 | EFO_0001059 | H26.9 | — | — | 2 | — | — | 2 |
| Graft vs host disease | D006086 | D89.81 | — | — | 1 | — | — | 1 | |
| Oral manifestations | D009912 | — | — | 1 | — | — | 1 | ||
| Rheumatoid arthritis | D001172 | EFO_0000685 | M06.9 | — | — | 1 | — | — | 1 |
| Seborrheic dermatitis | D012628 | L21 | — | — | 1 | — | — | 1 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Atopic dermatitis | D003876 | EFO_0000274 | L20 | 3 | 1 | — | — | — | 3 |
| Phlebitis | D010689 | EFO_1001395 | I80 | 1 | 1 | — | — | — | 1 |
| Stevens-johnson syndrome | D013262 | EFO_0004276 | L51.1 | 1 | 1 | — | — | — | 1 |
| Herpes labialis | D006560 | EFO_1001347 | B00.1 | — | 1 | — | — | — | 1 |
| Renal cell carcinoma | D002292 | — | 1 | — | — | — | 1 | ||
| Colorectal neoplasms | D015179 | — | 1 | — | — | — | 1 | ||
| Adenocarcinoma | D000230 | — | 1 | — | — | — | 1 |
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Healthy volunteers/patients | — | 3 | — | — | — | 1 | 4 | ||
| Vasoconstriction | D014661 | 1 | — | — | — | — | 1 | ||
| Skin and connective tissue diseases | D017437 | 1 | — | — | — | — | 1 | ||
| Oral ulcer | D019226 | HP_0000155 | 1 | — | — | — | — | 1 | |
| Connective tissue diseases | D003240 | EFO_1001986 | M35 | 1 | — | — | — | — | 1 |
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | CLOMIPHENE |
| INN | clomifene |
| Description | Clomifene, also known as clomiphene, is a medication used to treat infertility in women who do not ovulate, including those with polycystic ovary syndrome. Use results in a greater chance of twins. It is taken by mouth once a day, with a course of treatment that usually lasts for five days.
|
| Classification | Small molecule |
| Drug class | Selective estrogen receptor modulator; Progonadotropin |
| Image (chem structure or protein) | |
| Structure (InChI/SMILES or Protein Sequence) | CCN(CC)CCOc1ccc(C(=C(Cl)c2ccccc2)c2ccccc2)cc1 |
Identifiers
| PDB | — |
| CAS-ID | 911-45-5 |
| RxCUI | 2596 |
| ChEMBL ID | CHEMBL2355051 |
| ChEBI ID | 3752 |
| PubChem CID | 2800 |
| DrugBank | DB00882 |
| UNII ID | 1HRS458QU2 (ChemIDplus, GSRS) |
Target
Agency Approved
ESR1
ESR1
Organism
Homo sapiens
Gene name
ESR1
Gene synonyms
ESR, NR3A1
NCBI Gene ID
Protein name
estrogen receptor
Protein synonyms
E2 receptor alpha, ER-alpha, Estradiol receptor, estrogen nuclear receptor alpha, estrogen receptor alpha E1-E2-1-2, estrogen receptor alpha E1-N2-E2-1-2, Nuclear receptor subfamily 3 group A member 1, oestrogen receptor alpha
Uniprot ID
Mouse ortholog
Esr1 (13982)
estrogen receptor (Q9QY52)
Alternate
No data
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 6,192 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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3,162 adverse events reported
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