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Sensipar, Mimpara(cinacalcet)
Mimpara, Sensipar (cinacalcet) is a small molecule pharmaceutical. Cinacalcet was first approved as Sensipar on 2004-03-08. It is used to treat parathyroid neoplasms, primary hyperparathyroidism, and secondary hyperparathyroidism in the USA. It has been approved in Europe to treat hypercalcemia, hyperparathyroidism, parathyroid neoplasms, and secondary hyperparathyroidism. The pharmaceutical is active against extracellular calcium-sensing receptor. In addition, it is known to target metabotropic glutamate receptor 5.
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
neoplasmsD009369
nutritional and metabolic diseasesD009750
endocrine system diseasesD004700
Trade Name
FDA
EMA
Sensipar (generic drugs available since 2018-03-08)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Cinacalcet hydrochloride
Tradename
Company
Number
Date
Products
SENSIPARAmgenN-021688 RX2004-03-08
3 products, RLD, RS
Labels
FDA
EMA
Brand Name
Status
Last Update
cinacalcetANDA2023-06-07
sensiparNew Drug Application2023-02-04
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
parathyroid neoplasms—D010282—
primary hyperparathyroidismEFO_0008519D049950E21.0
secondary hyperparathyroidismEFO_1001173D006962—
Agency Specific
FDA
EMA
No data
Patent Expiration
Patent
Expires
Flag
FDA Information
Cinacalcet Hydrochloride, Sensipar, Amgen
78295952026-09-22DPU-1098
93754052026-09-22DP
ATC Codes
H: Systemic hormonal preparations, excl. sex hormones and insulins
— H05: Calcium homeostasis
— H05B: Anti-parathyroid agents
— H05BX: Other anti-parathyroid agents in atc
— H05BX01: Cinacalcet
HCPCS
Code
Description
J0604
Cinacalcet, oral, 1 mg, (for esrd on dialysis)
Clinical
Clinical Trials
73 clinical trials
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Indications Phases 4
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Secondary hyperparathyroidismD006962EFO_1001173291214337
Chronic renal insufficiencyD051436N181266—15
Chronic kidney failureD007676EFO_0003884N18.6—452112
Primary hyperparathyroidismD049950EFO_0008519E21.0—541211
HyperparathyroidismD006961EFO_0008506E21.3——3317
Kidney diseasesD007674EFO_0003086N08——32—5
Parathyroid neoplasmsD010282——21—3
OsteoporosisD010024EFO_0003882M81.0———2—2
Renal dialysisD006435EFO_0010690Z99.2——11—2
Renal insufficiencyD051437HP_0000083N19———1—1
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Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
HypercalcemiaD006934E83.52112——3
HypophosphatemiaD017674HP_0002148——1—12
Kidney transplantationD016030——1——1
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Prostatic neoplasmsD011471C61—1———1
Chronic kidney disease-mineral and bone disorderD012080EFO_1001152N25.0—1———1
Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Healthy volunteers/patients—1———12
Familial hypophosphatemic ricketsD0530981———12
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameCINACALCET
INNcinacalcet
Description
Cinacalcet is a secondary amino compound that is (1R)-1-(naphthalen-1-yl)ethanamine in which one of the hydrogens attached to the nitrogen is substituted by a 3-[3-(trifluoromethyl)phenyl]propyl group. It has a role as a calcimimetic and a P450 inhibitor. It is a member of naphthalenes, a secondary amino compound and a member of (trifluoromethyl)benzenes.
Classification
Small molecule
Drug classcalcium-sensing receptor (CaSR) agonists
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
C[C@@H](NCCCc1cccc(C(F)(F)F)c1)c1cccc2ccccc12
Identifiers
PDB—
CAS-ID226256-56-0
RxCUI407990
ChEMBL IDCHEMBL1201284
ChEBI ID48390
PubChem CID156419
DrugBankDB01012
UNII IDUAZ6V7728S (ChemIDplus, GSRS)
Target
Agency Approved
CASR
CASR
Organism
Homo sapiens
Gene name
CASR
Gene synonyms
GPRC2A, PCAR1
NCBI Gene ID
846
Protein name
extracellular calcium-sensing receptor
Protein synonyms
parathyroid Ca(2+)-sensing receptor 1, Parathyroid cell calcium-sensing receptor 1, PCaR1
Uniprot ID
Q4PJ19
Mouse ortholog
Casr (12374)
extracellular calcium-sensing receptor (Q9R1Y2)
Alternate
GRM5
GRM5
Organism
Homo sapiens
Gene name
GRM5
Gene synonyms
GPRC1E, MGLUR5
NCBI Gene ID
2915
Protein name
metabotropic glutamate receptor 5
Protein synonyms
glutamate receptor, metabotropic 5, protein phosphatase 1, regulatory subunit 86
Uniprot ID
P41594
Mouse ortholog
Grm5 (108071)
metabotropic glutamate receptor 5 (Q3UVX5)
Variants
Clinical Variant
No data
Financial
Sensipar - Amgen
$
€
£
₣
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Tabular view
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 3,418 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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70,628 adverse events reported
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