Cilostazol
Pletal (cilostazol) is a small molecule pharmaceutical. Cilostazol was first approved as Pletal on 1999-01-15. It is used to treat intermittent claudication, peripheral vascular diseases, and vascular graft occlusion in the USA. The pharmaceutical is active against cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B. In addition, it is known to target cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A.
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Commercial
Trade Name
FDA
EMA
No data
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Cilostazol
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| PLETAL | Otsuka | N-020863 DISCN | 1999-01-15 | 2 products, RLD |
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Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| cilostazol | ANDA | 2022-07-31 |
Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| intermittent claudication | EFO_0003876 | D007383 | I73.9 |
| peripheral vascular diseases | EFO_0003875 | D016491 | I73.9 |
| vascular graft occlusion | — | D006083 | — |
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
HCPCS
Code | Description |
|---|---|
| G9531 | Patient has documentation of ventricular shunt, brain tumor, multisystem trauma, or is currently taking an antiplatelet medication including: abciximab, anagrelide, cangrelor, cilostazol, clopidogrel, dipyridamole, eptifibatide, prasugrel, ticlopidine, ticagrelor, tirofiban, or vorapaxar |
Clinical
Clinical Trials
32 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Hiv infections | D015658 | EFO_0000764 | B20 | 3 | 2 | 2 | 1 | 5 | 12 |
| Cytomegalovirus retinitis | D017726 | EFO_1001302 | 1 | 3 | 2 | 2 | 3 | 10 | |
| Acute kidney injury | D058186 | HP_0001919 | N17 | — | — | — | 1 | — | 1 |
Indications Phases 3
No data
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Precancerous conditions | D011230 | 1 | 1 | — | — | — | 2 | ||
| Warts | D014860 | B07 | — | 1 | — | — | — | 1 | |
| Anus neoplasms | D001005 | EFO_0003835 | C21 | — | 1 | — | — | — | 1 |
| Sarcoma | D012509 | — | 1 | — | — | — | 1 | ||
| Acquired immunodeficiency syndrome | D000163 | EFO_0000765 | B20 | — | 1 | — | — | — | 1 |
Indications Phases 1
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Hiv | D006678 | O98.7 | — | — | — | — | 1 | 1 | |
| Urinary bladder diseases | D001745 | N32.9 | — | — | — | — | 1 | 1 | |
| Cystitis | D003556 | EFO_1000025 | N30 | — | — | — | — | 1 | 1 |
| Progressive multifocal leukoencephalopathy | D007968 | EFO_0007455 | A81.2 | — | — | — | — | 1 | 1 |
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | CILOSTAZOL |
| INN | cilostazol |
| Description | Cilostazol is a lactam that is 3,4-dihydroquinolin-2(1H)-one in which the hydrogen at position 6 is substituted by a 4-(1-cyclohexyl-1H-tetrazol-5-yl)butoxy group. It has a role as a bronchodilator agent, a vasodilator agent, a fibrin modulating drug, a platelet aggregation inhibitor, a neuroprotective agent, an anticoagulant and an EC 3.1.4.17 (3',5'-cyclic-nucleotide phosphodiesterase) inhibitor. It is a member of tetrazoles and a lactam. |
| Classification | Small molecule |
| Drug class | — |
| Image (chem structure or protein) | |
| Structure (InChI/SMILES or Protein Sequence) | O=C1CCc2cc(OCCCCc3nnnn3C3CCCCC3)ccc2N1 |
Identifiers
| PDB | — |
| CAS-ID | 73963-72-1 |
| RxCUI | 21107 |
| ChEMBL ID | CHEMBL799 |
| ChEBI ID | 31401 |
| PubChem CID | 2754 |
| DrugBank | DB01166 |
| UNII ID | N7Z035406B (ChemIDplus, GSRS) |
Target
Agency Approved
PDE3B
PDE3B
Organism
Homo sapiens
Gene name
PDE3B
Gene synonyms
NCBI Gene ID
Protein name
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B
Protein synonyms
CGI-PDE B, CGIP1, CGIPDE1, cGMP-inhibited 3',5'-cyclic phosphodiesterase B, Cyclic GMP-inhibited phosphodiesterase B, cyclic nucleotide phosphodiesterase, phosphodiesterase 3B, cGMP-inhibited
Uniprot ID
Mouse ortholog
Pde3b (18576)
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B (Q61409)
Alternate
PDE3A
PDE3A
Organism
Homo sapiens
Gene name
PDE3A
Gene synonyms
NCBI Gene ID
Protein name
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A
Protein synonyms
cAMP phosphodiesterase, myocardial cGMP-inhibited, cGI-PDE, CGI-PDE A, cGMP-inhibited 3',5'-cyclic phosphodiesterase A, cGMP-inhibited cAMP phosphodiesterase, Cyclic GMP-inhibited phosphodiesterase A, phosphodiesterase 3A, cGMP-inhibited
Uniprot ID
Mouse ortholog
Pde3a (54611)
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A (Q9Z0X4)
Variants
Clinical Variant
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Financial
No data
Trends
PubMed Central
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Additional graphs summarizing 5,942 documents
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Safety
Black-box Warning
Black-box warning for: Cilostazol
Adverse Events
Top Adverse Reactions
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747 adverse events reported
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