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Cilnidipine
Cilnidipine is a small molecule pharmaceutical. It is currently being investigated in clinical studies. It is known to target voltage-dependent N-type calcium channel subunit alpha-1B.
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Commercial
Therapeutic Areas
No data
Trade Name
FDA
EMA
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Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
No data
Labels
FDA
EMA
No data
Indications
FDA
EMA
No data
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
C: Cardiovascular system drugs
— C08: Calcium channel blockers
— C08C: Selective calcium channel blockers with mainly vascular effects
— C08CA: Dihydropyridine derivative selective calcium channel blockers with mainly vascular effects
— C08CA14: Cilnidipine
HCPCS
No data
Clinical
Clinical Trials
6 clinical trials
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Indications Phases 4
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
HypertensionD006973EFO_0000537I101—21—4
Autosomal dominant polycystic kidneyD016891EFO_1001496Q61.2—1—1—2
Metabolic syndromeD024821EFO_0000195E88.81———1—1
Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
StrokeD020521EFO_0000712I63.9——1——1
Indications Phases 2
No data
Indications Phases 1
No data
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameCILNIDIPINE
INNcilnidipine
Description
Cilnidipine is a diesterified 1,4-dihydropyridine-3,5-dicarboxylic acid. A calcium channel blocker, it is used as an antihypertensive. It has a role as a calcium channel blocker, an antihypertensive agent and a cardiovascular drug. It is a dihydropyridine, a 2-methoxyethyl ester and a C-nitro compound.
Classification
Small molecule
Drug classphenylpyridine vasodilators; tricyclic compounds
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
COCCOC(=O)C1=C(C)NC(C)=C(C(=O)OC/C=C/c2ccccc2)C1c1cccc([N+](=O)[O-])c1
Identifiers
PDB—
CAS-ID132203-70-4
RxCUI—
ChEMBL IDCHEMBL452076
ChEBI ID31399
PubChem CID5282138
DrugBankDB09232
UNII ID97T5AZ1JIP (ChemIDplus, GSRS)
Target
Agency Approved
No data
Alternate
CACNA1B
CACNA1B
Organism
Homo sapiens
Gene name
CACNA1B
Gene synonyms
CACH5, CACNL1A5
NCBI Gene ID
774
Protein name
voltage-dependent N-type calcium channel subunit alpha-1B
Protein synonyms
BIII, Brain calcium channel III, calcium channel alpha12.2 subunit, calcium channel, L type, alpha-1 polypeptide, Calcium channel, L type, alpha-1 polypeptide isoform 5, calcium channel, voltage-dependent, L type, alpha 1B subunit, calcium channel, voltage-dependent, N type, alpha 1B subunit, Cav2.2 voltage-gated Ca2+ channel, voltage-gated calcium channel alpha subunit Cav2.2, Voltage-gated calcium channel subunit alpha Cav2.2
Uniprot ID
Q00975
Mouse ortholog
Cacna1b (12287)
voltage-dependent N-type calcium channel subunit alpha-1B (Q60609)
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 644 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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104 adverse events reported
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