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Chlorpheniramine
Advil, Antagonate, Capsule, Chlor-trimeton, Codimal-l.a, Isoclor, Kloromin, Phenetron, Pyridamal, Teldrin, Triaminic, Tuxarin, Vituz, Zutripro (chlorpheniramine) is a small molecule pharmaceutical. Chlorpheniramine was first approved as Chlor-trimeton on 1982-01-01. It is used to treat allergic rhinitis perennial and urticaria in the USA. The pharmaceutical is active against histamine H1 receptor.
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
respiratory tract diseasesD012140
otorhinolaryngologic diseasesD010038
skin and connective tissue diseasesD017437
immune system diseasesD007154
Trade Name
FDA
EMA
Combinations
Advil, Tuxarin (generic drugs available since 2009-05-13, discontinued: Capsule, Chlor-trimeton, Codimal-l.a., Isoclor, Triaminic, Vituz, Zutripro)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Chlorpheniramine maleate
Tradename
Company
Number
Date
Products
EFIDAC 24 CHLORPHENIRAMINE MALEATEAlzaN-019746 DISCN1994-11-18
1 products
CHLOR-TRIMETONBayerN-007638 DISCN1982-01-01
2 products, RLD
TELDRINGSKN-017369 DISCN1982-01-01
2 products
CHLOR-TRIMETONMerck Sharp & DohmeN-006921 DISCN1982-01-01
2 products
CHLOR-TRIMETONMerck Sharp & DohmeN-008794 DISCN1982-01-01
1 products
CHLOR-TRIMETONMerck Sharp & DohmeN-008826 DISCN1982-01-01
1 products
Hide discontinued
Chlorpheniramine maleate
+
Codeine phosphate
Tradename
Company
Number
Date
Products
TUXARIN ERMainPointe PharmaceuticalsN-206323 RX2015-06-22
1 products
Chlorpheniramine maleate
+
Hydrocodone bitartrate
Tradename
Company
Number
Date
Products
VITUZPersion PharmaceuticalsN-204307 DISCN2013-02-20
1 products, RLD
Hide discontinued
Chlorpheniramine maleate
+
Hydrocodone bitartrate
+
Pseudoephedrine hydrochloride
Tradename
Company
Number
Date
Products
ZUTRIPROPersion PharmaceuticalsN-022439 DISCN2011-06-08
1 products, RLD
Hide discontinued
Chlorpheniramine maleate
+
Ibuprofen
+
Phenylephrine hydrochloride
Tradename
Company
Number
Date
Products
ADVIL MULTI-SYMPTOM COLD & FLUGSKN-022113 OTC2017-04-28
1 products, RLD, RS
ADVIL ALLERGY AND CONGESTION RELIEFGSKN-022113 OTC2011-12-21
1 products, RLD, RS
Chlorpheniramine maleate
+
Ibuprofen
+
Pseudoephedrine hydrochloride
Tradename
Company
Number
Date
Products
ADVIL ALLERGY SINUSGSKN-021441 OTC2002-12-19
1 products, RLD, RS
CHILDREN'S ADVIL ALLERGY SINUSGSKN-021587 OTC2004-02-24
1 products, RLD, RS
Chlorpheniramine maleate
+
Phenylpropanolamine hydrochloride
Tradename
Company
Number
Date
Products
COLD CAPSULE IVGRAHAM DMN-018793 DISCN1985-04-25
1 products
COLD CAPSULE VGRAHAM DMN-018794 DISCN1985-04-23
1 products
TRIAMINIC-12NovartisN-018115 DISCN1982-01-01
1 products
Hide discontinued
Chlorpheniramine maleate
+
Pseudoephedrine hydrochloride
Tradename
Company
Number
Date
Products
PSEUDOEPHEDRINE HYDROCHLORIDE AND CHLORPHENIRAMINE MALEATECentral PharmaceuticalsN-019428 DISCN1988-08-02
1 products
ISOCLORFisonsN-018747 DISCN1986-03-06
1 products
PSEUDOEPHEDRINE HYDROCHLORIDE AND CHLORPHENIRAMINE MALEATEGRAHAM DMN-018843 DISCN1985-03-18
1 products
PSEUDOEPHEDRINE HYDROCHLORIDE AND CHLORPHENIRAMINE MALEATEGRAHAM DMN-018844 DISCN1985-03-20
1 products
CODIMAL-L.A. 12Schwarz PharmaN-018935 DISCN1985-04-15
1 products
Hide discontinued
Chlorpheniramine maleate
+
Pseudoephedrine sulfate
Tradename
Company
Number
Date
Products
CHLOR-TRIMETONBayerN-018397 DISCN1982-01-01
1 products, RLD
Hide discontinued
Labels
FDA
EMA
Brand Name
Status
Last Update
advil dual action with acetaminophenNew Drug Application2023-04-13
cough and cold hbpOTC monograph final2023-06-17
triaminicOTC monograph final2020-12-17
tuxarinNew Drug Application2021-11-04
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
allergic rhinitis perennialEFO_1001417D012221J30.89
urticariaEFO_0005531D014581L50
Agency Specific
FDA
EMA
No data
Patent Expiration
Patent
Expires
Flag
FDA Information
Chlorpheniramine Maleate / Codeine Phosphate, Tuxarin Er, Mainpointe
90669422032-01-03U-1716
91079212032-01-03DP
Chlorpheniramine Maleate / Ibuprofen / Pseudoephedrine Hydrochloride, Advil Allergy Sinus, Glaxosmithkline
78632872027-02-28DP
Chlorpheniramine Maleate / Ibuprofen / Pseudoephedrine Hydrochloride, Children'S Advil Allergy Sinus, Glaxosmithkline
102386402024-05-25DP
ATC Codes
R: Respiratory system drugs
— R06: Antihistamines for systemic use
— R06A: Antihistamines for systemic use
— R06AB: Substituted alkylamines, systemic antihistamines
— R06AB04: Chlorphenamine
— R06AB54: Chlorphenamine, combinations
HCPCS
No data
Clinical
Clinical Trials
33 clinical trials
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Indications Phases 4
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Spinal anesthesiaD000775—1—326
PainD010146EFO_0003843R52——13—4
Uterine cervical incompetenceD002581EFO_0007202N88.3———2—2
Ambulatory surgical proceduresD000556———112
AnesthesiaD000758———112
Drug-related side effects and adverse reactionsD064420T88.7———1—1
AnalgesiaD000698———1—1
Cervical cerclageD023802———1—1
Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
CataractD002386EFO_0001059H26.9——1——1
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Inguinal herniaD006552HP_0000023K40—1——12
Pregnancy rateD018873—1———1
Postoperative painD010149G89.18—1———1
FlatfootD005413EFO_0003874M21.4—1———1
Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Cesarean sectionD0025851————1
Indications Without Phase
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Umbilical herniaD006554K42————11
HypotensionD007022EFO_0005251I95————11
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameCHLORPHENIRAMINE
INNchlorphenamine
Description
Chlorphenamine is a tertiary amino compound that is propylamine which is substituted at position 3 by a pyridin-2-yl group and a p-chlorophenyl group and in which the hydrogens attached to the nitrogen are replaced by methyl groups. A histamine H1 antagonist, it is used to relieve the symptoms of hay fever, rhinitis, urticaria, and asthma. It has a role as a H1-receptor antagonist, an antipruritic drug, a histamine antagonist, a serotonin uptake inhibitor, an antidepressant and an anti-allergic agent. It is a tertiary amino compound, a member of monochlorobenzenes and a member of pyridines.
Classification
Small molecule
Drug class—
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
CN(C)CCC(c1ccc(Cl)cc1)c1ccccn1
Identifiers
PDB—
CAS-ID132-22-9
RxCUI—
ChEMBL IDCHEMBL505
ChEBI ID52010
PubChem CID2725
DrugBankDB01114
UNII ID3U6IO1965U (ChemIDplus, GSRS)
Target
Agency Approved
HRH1
HRH1
Organism
Homo sapiens
Gene name
HRH1
Gene synonyms
NCBI Gene ID
3269
Protein name
histamine H1 receptor
Protein synonyms
histamine receptor, subclass H1
Uniprot ID
Q6P9E5
Mouse ortholog
Hrh1 (15465)
histamine H1 receptor (Q91XN3)
Alternate
No data
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 5,029 documents
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Safety
Black-box Warning
Black-box warning for: Tuxarin
Adverse Events
Top Adverse Reactions
Mock data
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82 adverse events reported
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